Vascular invasion in Hodgkin's disease: Its relationship to involvement of the spleen and other extranodal sites

Abstract

In 6 of 29 (20.7%) patients surgically staged for Hodgkin's disease, vascular invasion was demonstrated in either sections of the diagnostic lymph node biopsy or spleen removed at the time of laparotomy. Surgical staging showed that patients with this histologic feature had either Stage III or IV disease; only 43.5% of those in whom vascular invasion was not seen had such extensive disease. In addition, involvement of either the liver, lung, or bone marrow was found in 5 of 6 patients with vascular invasion while only one patient without this feature showed visceral involvement. These findings suggest that vascular invasion is a histopathologic feature of important prognostic value, since it may indicate that hematogenous dissemination has occurred. The association of vascular invasion of the spleen with unequivocal liver involvement in 2 of 3 cases suggests that hematogenous dissemination of Hodgkin's disease via the portal system may be a pathway for the spread of the disease to the liver.

A Successful Right Axillary Artery Graft to Repair a Ruptured Axillary Artery Due to the Involvement of Lymphoma: Report of a Case

“…Diffuse large B-cell lymphoma is highly invasive, with local compression of vessels or airways, involvement of the peripheral nerves, and the destruction of bone. 5 To our knowledge, although vascular invasion of the tumor has been described in Hodgkin's disease, 6 this situation has not yet been described for cases of diffuse large B-cell lymphoma. Limb salvage surgery for cancer may be required.…”

Correlation of clinical parameters with apoptotic biological markers in prognosis of classical Hodgkin lymphoma

“…Invazija vaskulnih struktura relativno je česta kod obolelih sa limfocitnom deplecijom. Ona može da se javi i u bolesnika sa invazijom slezine nodulskom sklerozom i u podtipu mešovite celularnosti (90)(91)(92).…”