Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure

Artham, Sandeep; Fouda, Abdelrahman Y.; El-Remessy, Azza B.; Fagan, Susan C.

doi:10.14800/rci.774

Cited by 4 publications

(1 citation statement)

References 35 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypertension is also a higher risk factor for cognitive decline and dementia, including Alzheimer's disease (AD) (15)(16)(17)(18). Recent evidences suggest that inhibition of reninangiotensin system (RAS) in this system may be beneficial in attenuating cognitive deficits observed in aging, AD, Parkinson's disease (PD), vascular cognitive impairment, and post-stroke cognitive impairment (19)(20)(21)(22). Renin has been identified within neurons and astrocytes (23).…”

Section: Introductionmentioning

confidence: 99%

Positive Association Between Plasma Aldosterone Concentration and White Matter Lesions in Patients With Hypertension

Yuan

Liu

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

Background and ObjectiveWhite matter lesions (WMLs) are imaging changes in MRI of cerebral small vessel disease associated with vascular risk factors, increasing the risk of dementia, depression, and stroke. Aldosterone (ALD) or activation of mineralocorticoid receptor (MR) causes cerebrovascular injury in a mouse model. We aimed to analyze the relationship between ALD and WMLs in a population with hypertension.MethodsWe conducted a retrospective review of all patients screened for causes of secondary hypertension. We enrolled 547 patients with WMLs and matched these to controls without WMLs at a 1:1 ratio. White matter lesion load was assessed by using a modified Scheltens’ scale.ResultsAmong the analytic sample (N = 1,094) with ages ranging from 30 to 64 years, 62.2% were male. We divided plasma ALD concentration (PAC), plasma renin activity (PRA), and ALD–renin ratio (ARR) into the third tertile (Q3), second tertile (Q2), and first tertile (Q1). We also analyzed them simultaneously as continuous variables. Multivariate logistic regression analysis showed that participants in Q3 (>17.26 ng/dl) of PAC (OR 1.59, 95% CI 1.15, 2.19), Q3 (<0.80 ng/dl) of PRA (OR 2.50, 95% CI 1.81, 3.44), and Q3 (>18.59 ng/dl per ng/ml*h) of ARR (OR 2.90, 95% CI 2.10, 4.01) had a significantly higher risk of WMLs than those in Q1 (<12.48) of PAC, Q1 (>2.19) of PRA, and Q1 (<6.96) of ARR. In linear regression analysis, we separately analyzed the correlation between the modified Scheltens’ scale score and log(PAC) (β = 2.36; 95% CI 1.30, 3.41; p < 0.001), log(PRA) (β = −1.76; 95% CI −2.09, −1.43; p < 0.001), and log(ARR) (β = 1.86; 95% CI 1.55, 2.17; p < 0.001), which were all significantly correlated with white matter lesion load, after adjusting for confounding factors. Simple mediation analyses showed that systolic blood pressure (SBP) or diastolic blood pressure (DBP) mediated −3.83% or −2.66% of the association between PAC and white matter lesion load, respectively. In stratified analyses, there was no evidence of subgroup heterogeneity concerning the change in the risk of WMLs (p > 0.05 for interaction for all).ConclusionHigher PAC, especially in PAC >17.26 ng/dl, increased the risk of WMLs. PAC was positively associated with white matter lesion load independent of SBP or DBP.

show abstract

Section: Introductionmentioning

confidence: 99%

Positive Association Between Plasma Aldosterone Concentration and White Matter Lesions in Patients With Hypertension

Yuan

Liu

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Pharmacogenomics Informs Cardiovascular Pharmacotherapy

Babayeva

Azzi

Loewy

2022

Methods in Molecular Biology

View full text Add to dashboard Cite

Effects of angiotensin II receptor blockers on the course of the disease in patients with stable ischemic heart disease

Кочергина

Кочергин

2022

Kompleks. probl. serdečno-sosud. zabol.

View full text Add to dashboard Cite

Highlights. The review synthesizes the results of clinical studies on the use of sartans. This topic is highly relevant due to the antihypertensive, metabolic and organ-protective effect of sartans, which can positively affect the course of coronary atherosclerosis.Abstract. Angiotensin II receptor blockers (sartans) are widely used to treat cardiovascular diseases. This class of drugs has antihypertensive and metabolic effects and organ-protective capabilities. Currently, sartans are of high interest due to their pleiotropic effect: improved lipid metabolism, antidiabetogenic action, nephroprotection, and, as a result, reduced total cardiovascular risk. The article presents an overview of clinical data on the use of sartans in patients with ischemic heart disease, the mechanisms of organ-protective effects and prospects of using this class of drugs for total cardiovascular risk reduction. The following data sources were used: e-Library, ClinicalTrials.gov, PubMed, trialbulletin.com, smartpatients.com, BioPortfolio.com.

show abstract

Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure

Cited by 4 publications

References 35 publications

Positive Association Between Plasma Aldosterone Concentration and White Matter Lesions in Patients With Hypertension

Positive Association Between Plasma Aldosterone Concentration and White Matter Lesions in Patients With Hypertension

Pharmacogenomics Informs Cardiovascular Pharmacotherapy

Effects of angiotensin II receptor blockers on the course of the disease in patients with stable ischemic heart disease

Contact Info

Product

Resources

About