Vascular Reactivity and Effect of Serum in a Rat Model of Hypertriglyceridemia and Hypertension

Baños, Guadalupe; Carvajal, Karla; Cardoso, Guillermo; Zamora, José; Franco, Martha

doi:10.1016/s0895-7061(96)00400-1

Cited by 34 publications

(47 citation statements)

References 33 publications

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“…Animals were divided in two groups: the control group (C; n=12), which received a standard diet (Lab Diet 2018S, Harlan Teklad Inc.), and the metabolic syndrome group (MS; n=32), which received the standard diet plus 30% sucrose in drinking water ( Fig. 1) [3]. After animals were fed ad libitum, during 21 weeks, body weight and blood pressure were measured, blood samples were obtained from animal's tails, and serum insulin, glucose, triacylglycerols, free fatty acids (FFAs), and tumor necrosis factor (TNF)-α were measured.…”

Section: Methodsmentioning

confidence: 99%

Dietary n-3 polyunsaturated fatty acids modify fatty acid composition in hepatic and abdominal adipose tissue of sucrose-induced obese rats

et al. 2011

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The fatty acid profile of hepatocytes and adipocytes is determined by the composition of the dietary lipids. It remains unclear which fatty acid components contribute to the development or reduction of insulin resistance. The present work examined the fatty acid composition of both tissues in sucrose-induced obese rats receiving fish oil to determine whether the effect of dietary (n-3) polyunsaturated fatty acids (PUFAs) on the reversion of metabolic syndrome in these rats is associated to changes in the fatty acid composition of hepatocyte and adipocyte membrane lipids. Animals with metabolic syndrome were divided into a corn-canola oil diet group and a fish oil diet group, and tissues fatty acids composition were analyzed after 6 weeks of dietary treatment. Fatty acid profiles of the total membrane lipids were modified by the fatty acid composition of the diets fed to rats. N-3 PUFAs levels in animals receiving the fish oil diet plus sucrose in drinking water were significantly higher than in animals under corn-canola oil diets. It is concluded that in sucrose-induced obese rats, consumption of dietary fish oil had beneficial effects on the metabolic syndrome and that such effects would be conditioned by the changes in the n-3 PUFAs composition in hepatic and adipose tissues because they alter membrane properties and modify the type of substrates available for the production of active lipid metabolites acting on insulin resistance and obesity.

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Section: Methodsmentioning

confidence: 99%

Dietary n-3 polyunsaturated fatty acids modify fatty acid composition in hepatic and abdominal adipose tissue of sucrose-induced obese rats

et al. 2011

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“…Therefore, the present study was carried out to assess the antihypertensive action of TFH-SR in an insulin-resistant rodent model developed by feeding a high-sucrose diet (Buňag et al, 1983;Reaven and Ho, 1991;McDonald, 1995;Baňos et al, 1997;Oliart-Ros et al, 2001) and further to investigate whether it could regulate insulin and angiotensin levels, which are the most important two bioactive peptides in the body.…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats

Pang

Zhao

Wen

et al. 2008

Journal of Ethnopharmacology

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“…In our laboratory, we developed an animal model of intraabdominal fat accumulation, induced by the addition of sucrose to the drinking water of Wistar rats (1,19), a variant of the fructose-induced hypertriglyceridemia and hypertension animal model (26,41). Intra-abdominal fat accumulation in this model is associated with the development of high BP, as described elsewhere (29).…”

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Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats

Hafidi¹,

Pérez²,

Zamora³

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

106

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os. Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. Am J Physiol Regul Integr Comp Physiol 287: R1387-R1393, 2004. First published August 26, 2004 doi:10.1152/ajpregu.00159.2004The study investigated the mechanism by which glycine protects against increased circulating nonesterified fatty acids (NEFA), fat cell size, intra-abdominal fat accumulation, and blood pressure (BP) induced in male Wistar rats by sucrose ingestion. The addition of 1% glycine to the drinking water containing 30% sucrose, for 4 wk, markedly reduced high BP in sucrose-fed rats (SFR) (122.3 Ϯ 5.6 vs. 147.6 Ϯ 5.4 mmHg in SFR without glycine, P Ͻ 0.001). Decreases in plasma triglyceride (TG) levels (0.9 Ϯ 0.3 vs. 1.4 Ϯ 0.3 mM, P Ͻ 0.001), intra-abdominal fat (6.8 Ϯ 2.16 vs. 14.8 Ϯ 4.0 g, P Ͻ 0.01), and adipose cell size were observed in SFR treated with glycine compared with SFR without treatment. Total NEFA concentration in the plasma of SFR was significantly decreased by glycine intake (0.64 Ϯ 0.08 vs. 1.11 Ϯ 0.09 mM in SFR without glycine, P Ͻ 0.001). In control animals, glycine decreased glucose, TGs, and total NEFA but without reaching significance. In SFR treated with glycine, mitochondrial respiration, as an indicator of the rate of fat oxidation, showed an increase in the state IV oxidation rate of the ␤-oxidation substrates octanoic acid and palmitoyl carnitine. This suggests an enhancement of hepatic fatty acid metabolism, i.e., in their transport, activation, or ␤-oxidation. These findings imply that the protection by glycine against elevated BP might be attributed to its effect in increasing fatty acid oxidation, reducing intra-abdominal fat accumulation and circulating NEFA, which have been proposed as links between obesity and hypertension. obesity; mitochondrial oxygen uptake; fatty acid oxidation OBESITY is a significant human health problem; its incidence is reaching epidemic proportions in many Western countries (2, 31). Obesity with fat accumulation predominantly in the abdominal cavity is more frequently associated with disorders of glucose and lipid metabolism than is subcutaneous fat obesity (6, 17). It is well known that increased intra-abdominal fat accumulation is also associated with elevated circulating nonesterified fatty acids (NEFA) (33), resulting from the increased lipolytic activity in adipose tissue. High levels of circulating NEFA have been assumed to be a possible link between intra-abdominal fat accumulation and elevated blood pressure (BP) (9,34,46,49).Several factors are known to be involved in the development of intra-abdominal adiposity in both humans and animals, including genetic and environmental factors, such as excessive fat or carbohydrate intake and lack of physical exercise (8, 44). Thus several animal models of obesity have been developed to investigate the mechanism by which obesity induces hypertension, hyperinsulinemia, and insulin resistance.In our laboratory, we developed an animal model of intraabdominal fat accumulation, indu...

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Vascular Reactivity and Effect of Serum in a Rat Model of Hypertriglyceridemia and Hypertension

Cited by 34 publications

References 33 publications

Dietary n-3 polyunsaturated fatty acids modify fatty acid composition in hepatic and abdominal adipose tissue of sucrose-induced obese rats

Dietary n-3 polyunsaturated fatty acids modify fatty acid composition in hepatic and abdominal adipose tissue of sucrose-induced obese rats

Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats

Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats

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