Vascular reactivity in rats with glycerol‐induced acute renal failure

Bowmer, C J; Clarke, Colette A.; Comer, Mary B.; Yates, M S

doi:10.1111/j.1476-5381.1984.tb10745.x

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…previous study (Bowmer et al 1984) we have noted diminished contractile responses of both portal veins and aortae from rats with ARF to angiotensin and noradrenaline. Furthermore, in the present study we have found reduced contractions of the portal vein of uraemic rats to the a,agonist methoxamine and to the a2-agonist B-HT 920.…”

Section: Discussionsupporting

confidence: 49%

“…The study of Rascher et al (1982) noted a diminished constrictor response, specific for noradrenaline, in the perfused hind limb of rats with chronic renal failure. In our study of rats with acute renal failure (ARF) we observed reduced contractile responses of aortic strips and portal vein segments to noradrenaline, angiotensin and potassium chloride (Bowmer et al 1984).…”

mentioning

confidence: 71%

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Vascular Smooth Muscle Function in Rats with Acute Renal Failure

Douglas¹,

Bowmer²,

Yates³

1989

Journal of Pharmacy and Pharmacology

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Vascular smooth muscle function in rats with glycerol-induced acute renal failure (ARF) was investigated by recording both the contractile responses of portal vein segments and the relaxant responses depressed contractile responses to the alpha 1-agonist methoxamine, the alpha 2-agonist B-HT 920 and to the calcium agonist BAY K 8644 when compared with controls. Both isoprenaline and nitroprusside produced 100% reversal of KCl induced tone in control aortic rings but in rings from rats with ARF complete reversal of of tone could not be obtained with either dilator drug. It is suggested that a defect in mitochondrial function and hence energy supply may account for the diminished ability of vascular preparations from rats with ARF to constrict and relax.

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Section: Discussionsupporting

confidence: 49%

mentioning

confidence: 71%

Vascular Smooth Muscle Function in Rats with Acute Renal Failure

Douglas¹,

Bowmer²,

Yates³

1989

Journal of Pharmacy and Pharmacology

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Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside, on prostaglandin biosynthesis and inactivation

Alcaraz

Hoult

1985

Biochemical Pharmacology

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Cardiovascular responses in spontaneously hypertensive rats with acute renal failure

Yates

Bowmer

Brown

1984

Journal of Pharmacy and Pharmacology

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Cardiovascular status and reactivity have been investigated in spontaneously hypertensive rats (SHR) with glycerol-induced acute renal failure. SHR with acute renal failure had significantly lower mean arterial blood pressures and heart rates. The pressor responses to noradrenaline and the chronotropic responses to right cervical sympathetic and vagal nerve stimulation were diminished in uraemic SHR compared to control SHR. The cardiovascular depression observed in SHR with acute renal failure was similar to that previously noted in normotensive rats with acute renal impairment.

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Vascular reactivity in rats with glycerol‐induced acute renal failure

Cited by 5 publications

References 9 publications

Vascular Smooth Muscle Function in Rats with Acute Renal Failure

Vascular Smooth Muscle Function in Rats with Acute Renal Failure

Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside, on prostaglandin biosynthesis and inactivation

Cardiovascular responses in spontaneously hypertensive rats with acute renal failure

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