Vascular risk factors and erectile dysfunction

Sullivan, M. X.; Keoghane, S.R.; Miller, Marek

doi:10.1046/j.1464-410x.2001.02211.x

Cited by 191 publications

(148 citation statements)

References 87 publications

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“…7 More recently, the importance of cavernosal relaxation in the erectile process has become apparent. Impairment of endothelium-dependent relaxation in numerous vascular beds in men with hypercholesterolemia has been clearly evidenced.…”

Section: Discussionmentioning

confidence: 99%

The relationship between lipid profile and erectile dysfunction

2005

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Section: Discussionmentioning

confidence: 99%

The relationship between lipid profile and erectile dysfunction

2005

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“…34 Wolf and Shulman concluded that the changes of endothelium-derived relaxing factor, NO, prostaglandin, prostacycline and thromboxane might contribute to smoking-induced ED. 35 Tengs and Osgood performed a meta-analysis of literature over the last 20 years and revealed that 40% of impotent men were current smokers compared with 28% of men in the general population.…”

Section: Tobaccomentioning

confidence: 99%

Erectile Dysfunction Associated with Psychoactive Substances

Jiann

2008

Chonnam Med J

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Psychoactive substances are believed to be aphrodisiac; but in reality they have deleterious effects on all the aspects of sexual function. The purpose of this article is to review and summarize the available scientific literature on the impact of psychoactive substances, including alcohol, tobacco and illicit drugs on erectile dysfunction (ED) in men. Almost all of them have been reported to be associated with ED. These substances may exert their inhibitory effect on erection through their effects on central neurotransmitter pathways (serotogenic, adrenergic or dopaminergic). Besides, some also may exhibit vasoconstricting properties (cocaine), impair endothelium function (nicotine) or suppress the release of luteinizing hormone from the pituitary, resulting in hypogonadism (morphine) to induce ED. The relationship between ED and psychoactive substances is attributed not only to pharmacological effects, but also to psychological and social reactions to substance dependence. Whether withdrawal from the substances could restore erectile function remains unknown. However, human and animal studies demonstrated that the effects of neurological damage from chronic substance abuse are long-lasting. This information of sexual consequence of the substances will be of great general interest and may serve as a powerful tool to healthcare providers.

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“…[1][2][3][4] All the clinical or epidemiological studies carried out to date have tried to identify causal factors or predictors of ED: in addition to aging, cardiovascular diseases, 5 diabetes, 6 prostate disease, 7 depression 8 and a number of treatments 9 (particularly with hormones, and antihypertensive and antiulcer drugs) have been associated with increased risk, but ED also affects men without any clinically apparent disease.…”

mentioning

confidence: 99%

Prevalence of erectile dysfunction and associated factors among men without concomitant diseases: a population study

et al. 2003

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We interviewed a population sample of 2412 men aged 40-70 y in Brazil, Italy, Japan and Malaysia about medical history, lifestyle habits and sexual behavior. Men were classified as having moderate or complete erectile dysfunction (ED) if they reported to be sometimes or never able to achieve and maintain an erection satisfactory for sexual intercourse, respectively. There were 1335 men with no diagnosis of cardiovascular or prostate diseases, diabetes, ulcer or depression, nor taking hormones. The prevalence of ED was 16.1%. ED was associated with age (the risk increased 8% per y), moderate (odds ratio (OR) ¼ 2.2) or severe (OR ¼ 4.9) lower urinary tract symptoms and smoking (OR ¼ 2.3 for 430 cigarettes/day). It was inversely associated with physical activity (OR ¼ 0.5) and higher educational levels. Between the ages of 40 and 70 y, almost one in six 'healthy' men is affected by ED. Further research should look at preclinical disease stages and genetic factors.

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Vascular risk factors and erectile dysfunction

Cited by 191 publications

References 87 publications

The relationship between lipid profile and erectile dysfunction

The relationship between lipid profile and erectile dysfunction

Erectile Dysfunction Associated with Psychoactive Substances

Prevalence of erectile dysfunction and associated factors among men without concomitant diseases: a population study

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