2020
DOI: 10.1038/s41467-020-19515-0
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Vascular surveillance by haptotactic blood platelets in inflammation and infection

Abstract: Breakdown of vascular barriers is a major complication of inflammatory diseases. Anucleate platelets form blood-clots during thrombosis, but also play a crucial role in inflammation. While spatio-temporal dynamics of clot formation are well characterized, the cell-biological mechanisms of platelet recruitment to inflammatory micro-environments remain incompletely understood. Here we identify Arp2/3-dependent lamellipodia formation as a prominent morphological feature of immune-responsive platelets. Platelets u… Show more

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Cited by 59 publications
(80 citation statements)
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“…An increase in MPV indicates that the body is in a potentially proinflammatory state and further cascades. The amplified inflammatory response can lead to aggravated destruction of the blood-brain barrier, causing secondary brain damage [ 20 , 21 ]. (2) The higher the risk of thrombosis in patients with high MPV levels, the greater the risk of thrombosis, which can cause repeated embolization of small blood vessels in the local brain tissue and aggravate nerves and functional impairment [ 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…An increase in MPV indicates that the body is in a potentially proinflammatory state and further cascades. The amplified inflammatory response can lead to aggravated destruction of the blood-brain barrier, causing secondary brain damage [ 20 , 21 ]. (2) The higher the risk of thrombosis in patients with high MPV levels, the greater the risk of thrombosis, which can cause repeated embolization of small blood vessels in the local brain tissue and aggravate nerves and functional impairment [ 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…These cell types have a tightly regulated interplay, which has been uncovered during the past decade. Platelets can migrate within the vasculature — a process distinct from adhesion, aggregation or clot contraction — and function as mechano-scavengers that collect bacteria on their surface and present them to neutrophils 18 , 19 . Platelet migration is actomyosin dependent and mediated through the interaction of αIIbβ3 integrin with the surrounding fibrinogen environment.…”
Section: Immunothrombosis: An Effector Mechanism In Host Defencementioning
confidence: 99%
“…This concept has been extended by Haile et al [53], arguing that PF4 plays a broad role in innate immunity and inflammatory responses. Besides these PF4-related interactions, PF4-independent platelet-bacterial interactions are an accepted general mechanism of host defense [54,55].…”
Section: J O U R N a L P R E -P R O O Fmentioning
confidence: 99%