Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma

Cheng, Wen-Fang; Lee, Chien‐Nan; Chu, Jan Show; Chen, Chi-An; Chen, Tzer-Ming; Shau, Wen–Yi; Hsieh, M.S.P.H. Chang-Yao; Hsieh, Fon‐Jou

doi:10.1002/(sici)1097-0142(19990201)85:3<651::aid-cncr15>3.0.co;2-9

Cited by 105 publications

(64 citation statements)

References 17 publications

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“…However, results of other studies indicated moderate to poor correlations ( [Cheng et al, 1999], [Fleischer et al, 1999] and [Yang et al, 2002]). The discrepancy, in part, might have been due to differences in techniques used.…”

Section: Discussionmentioning

confidence: 94%

Correlation of quantified contrast-enhanced power Doppler ultrasonography with immunofluorescent analysis of microvessel density in spontaneous canine tumours

Ohlerth¹,

Wergin²,

Bley³

et al. 2010

The Veterinary Journal

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Conventionally, tumour vascularity is assessed invasively by immunofluorescent analysis. Quantified contrast-enhanced power Doppler ultrasound has been used to measure tumour angiogenesis non-invasively in humans and experimental animals. The purpose of this study was to correlate quantified contrast-enhanced power Doppler ultrasound with immunofluorescent results in 45 spontaneous canine tumours. With power Doppler, mean vascularity was high in squamous cell carcinomas, moderate in malignant oral melanomas and low in sarcomas. There was high mean vascularity in squamous cell carcinomas and low mean vascularity in sarcomas and malignant oral melanomas. Although Doppler parameters correlated moderately with microvascular density for all tumours (P = 0.004, r = 0.4), they did not correlate within histology groups. These analyses show that vascularity differs among canine tumour histology groups. However, dependent on the method used, measurement of tumour vascularity can provide different biological information.

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Section: Discussionmentioning

confidence: 94%

Correlation of quantified contrast-enhanced power Doppler ultrasonography with immunofluorescent analysis of microvessel density in spontaneous canine tumours

Ohlerth¹,

Wergin²,

Bley³

et al. 2010

The Veterinary Journal

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“…Cheng et al reported a novel vascular index (VI) for the in vivo assessment of angiogenesis in patients with cervical carcinoma [26]. They evaluated 35 patients with stage IbIIa cervical carcinoma by transvaginal power Doppler ultrasound, and using image processor software they developed a vascular index (VI = number of colored pixels/number of total pixels) for each tumor.…”

Section: Transvaginal Color Doppler In Cervical Cancermentioning

confidence: 99%

The Role of Ultrasound in the Assessment of Uterine Cervical Cancer

Alcázar

Arribas²,

Mínguez

et al. 2014

J Obstet Gynecol India

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Uterine cervical cancer is the second most frequent gynecological malignancy worldwide. The assessment of the extent of disease is essential for planning optimal treatment. Imaging techniques are increasingly used in the pre-treatment work-up of cervical cancer. Currently, MRI for local extent of disease evaluation and PET-scan for distant disease assessment are considered as first-line techniques. Notwithstanding, in the last few years, ultrasound has gained attention as an imaging technique for evaluating women with cervical cancer. In this paper, current knowledge about the use of ultrasound for assessing uterine cervical cancer will be reviewed and discussed.

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“…A number of techniques exist to assess this, including contrast enhanced magnetic resonance imaging (MRI) Anderson et al, 2001) colour Doppler ultrasound (Huber et al, 1994;Delorme and Knopp, 1998;Cheng et al, 1999) and positron emission tomography (Fanelli et al, 1999;Anderson et al, 2001). There is some evidence to show that radiological imaging can detect differences in IMD.…”

Section: Imd and Intra-tumoural Microvascular Characteristicsmentioning

confidence: 99%

Intra-tumoural microvessel density in human solid tumours

2002

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Over the last decade assessment of angiogenesis has emerged as a potentially useful biological prognostic and predictive factor in human solid tumours. With the development of highly specific endothelial markers that can be assessed in histological archival specimens, several quantitative studies have been performed in various solid tumours. The majority of published studies have shown a positive correlation between intra-tumoural microvessel density, a measure of tumour angiogenesis, and prognosis in solid tumours. A minority of studies have not demonstrated an association and this may be attributed to significant differences in the methodologies employed for sample selection, immunostaining techniques, vessel counting and statistical analysis, although a number of biological differences may account for the discrepancy. In this review we evaluate the quantification of angiogenesis by immunohistochemistry, the relationship between tumour vascularity and metastasis, and the clinicopathological studies correlating intra-tumoral microvessel density with prognosis and response to anti-cancer therapy. In view of the extensive nature of this retrospective body of data, comparative studies are needed to identify the optimum technique and endothelial antigens (activated or pan-endothelial antigens) but subsequently prospective studies that allocate treatment on the basis of microvessel density are required. British Journal of Cancer (2002) Angiogenesis is the process in which new blood vessels arise from existing ones. This is present physiologically in the adult during wound healing, the development of the ovarian follicle and corpus luteum and in the proliferating endometrium. Pathological angiogenesis is also a component of much diverse pathology ranging from diabetes and atherosclerosis to cancer, a disease that cannot progress without the formation of new blood vessels (Folkman, 1972).The measurement of angiogenesis is complicated by the fact that it is a dynamic process yet most studies to date have focused on the product of angiogenesis, the microvessel density, which was analysed at a particular point in time. Accepting this caveat there are extensive data in which the microvessel density correlates with metastasis and survival. Here, we discuss the relationship between angiogenesis and the intra-tumoural microvessel density (IMD), review the different techniques that have been used to measure IMD and then discuss the reasons why this relationship does not always hold. IMD AS A MEASURE OF TUMOUR ANGIOGENESISAs angiogenesis is a dynamic process, comparisons with snapshot views of the tumour, as are seen in biopsy analyses, are not straightforward. On the other hand the only approaches that are available in the clinic for the serial measurement of tumour angiogenesis involve molecular imaging strategies, such as contrastenhanced magnetic resonance imaging (MRI) and positron emission tomography (PET), that do not resolve data at the microscopic level. Thus it is important to assess the relationship between IMD and...

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Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma

Cited by 105 publications

References 17 publications

Correlation of quantified contrast-enhanced power Doppler ultrasonography with immunofluorescent analysis of microvessel density in spontaneous canine tumours

Correlation of quantified contrast-enhanced power Doppler ultrasonography with immunofluorescent analysis of microvessel density in spontaneous canine tumours

The Role of Ultrasound in the Assessment of Uterine Cervical Cancer

Intra-tumoural microvessel density in human solid tumours

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