Vasculitic Ulcers

Papi, Massimo; Papi, Claudia

doi:10.1177/1534734615621220

Cited by 24 publications

(29 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Histopathological feature showed leukocytoclastic vasculitis with predominant neutrophil granulocytes and fibrinoid necrosis of the vessel wall. 11 Pyoderma gangrenosum (PG) occurred commonly on the lower legs with predilection on pretibial area but can occur on other sites of the body including breast, hand, trunk, head, and neck. PG ulcer starts as a follicular pustule with rapid growth, tissue necrosis, and enlargement of the area.…”

Section: Discussionmentioning

confidence: 99%

Necrotic lower extremities ulcers caused by calciphylaxis in chronic renal failure patient

Suryawati¹,

Saputra²

2018

Bali Dermatology and Venereology Journal

View full text Add to dashboard Cite

Introduction: Lower extremity ulcers often create diagnostic challenges and influence patient morbidity and mortality. The most common causes are venous insufficiency, arterial insufficiency, and neuropathic. Ulcers associated with systemic condition often face diagnostic and therapeutic challenge. We report a necrotic lower extremity ulcer caused by calciphylaxis in a patient with chronic renal failure. Case: We reported a 48-year-old Javanese woman, complained of painful lower extremities ulcers since 1.5 months ago. The patient had a history of renal failure and hypertension, undergone routine hemodialysis since 13 years ago, and used Continuous Ambulatory Peritoneal Dialysis (CAPD) since one year ago. Dermatology status on dorsum pedis sinister as well as cruris dexter and sinister showed multiple ulcers on livid skin covered by black eschar, accompanied by tenderness. Laboratory results showed anemia (Hb 7.6), hypoalbuminemia (2.7), increased serum urea level (170.4 mg/dl), increased serum creatinine (11.23 mg/dl), increased calcium (10.4 mg/dl), high inorganic phosphorus (8.5 mg/dl) and high parathyroid hormone (2,164). BOF examination showed abdominal calcification, while radiographic examination on cruris dexter et sinister showed soft tissue calcification and osteoporosis. Histopathology result supported the presence of calciphylaxis. The patient was diagnosed with stage V chronic renal failure, hypertension, and calciphylaxis caused by secondary hyperparathyroidism. She was managed by low calcium and phosphate diet, lanthanum, paracetamol, folic acid, adalat oros, captopril and wound debridement. Conclusion: Calciphylaxis is a rare phenomenon of cutaneous necrosis associated with end-stage renal disease. Control of end-stage renal disease may be an important factor for treatment of calciphylaxis and patient with calciphylaxis usually had a poor prognosis.Keywords: necrotic lower extremity ulcer, chronic renal failure, calciphylaxis

show abstract

Section: Discussionmentioning

confidence: 99%

Necrotic lower extremities ulcers caused by calciphylaxis in chronic renal failure patient

Suryawati¹,

Saputra²

2018

Bali Dermatology and Venereology Journal

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4] We are deeply obliged to the founding editor, Professor Raj Mani, for his exemplary and pioneer work over many years. Among the journal's contents, diabetic foot disease, [5][6][7] vascular disease and related technology, 8,9 as well as various other ulcers 10,11 are of paramount importance, and so they will be in the future.…”

Section: Editorialmentioning

confidence: 99%

Progress in Wound Healing: Wisdom Not Consumed in Confidence?

Παπάνας

Papi²

2019

The International Journal of Lower Extremity Wounds

Self Cite

View full text Add to dashboard Cite

“…Vasculitis can affect any type of vessels in any organ of the body including the skin. The most common manifestation of cutaneous vasculitis is palpable purpura 2 but painful nonhealing ulceration of the skin is a threatening manifestation of vasculitis 4,5 …”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of skin grafting in treatment of vasculitic ulcer and pyoderma gangrenosum—A systematic review

Morgenstjerne‐Schwenck

Knudsen

Prasad

2020

Wound Repair Regeneration

View full text Add to dashboard Cite

Chronic painful ulcers caused by pyoderma gangrenosum (PG) and cutaneous vasculitis remain to be a therapeutic challenge. Skin grafts have been used with success in selected cases but are generally avoided due to the fear of pathergy. The aim of this study was to investigate the safety and efficacy of skin grafting in the treatment of primary vasculitic ulcer (PVU) and PG. MEDLINE, Embase, the Cochrane Library, http://clinicaltrial.gov, and WHO International Clinical Trials Registry Platform (ICTRP) were searched from inception to March 2020. A search for grey literature was conducted in May 2020. We included studies assessing the efficacy and safety of skin grafting in the treatment of PG and PVU. Studies were only included if skin grafting was performed after establishment of PG or PVU diagnosis. A total of 721 articles was identified through the database search of which 92 were included in this study. Ten articles were identified by handsearching the reference list of included studies. Finally, 102 articles describing 212 wounds in 153 patients were included. Complete healing was found in 75.5% of the wounds. The average time to complete was 10.8 weeks (95% CI 6.1‐15.6). The mean donor site healing time was 1.9 weeks (95% CI 0.52‐3.20). Pathergy was reported in 8 (5.2%) patients. One patient had severe infection related to skin grafting. A statistically significant difference in the number of patients receiving preoperative (P = .0079) and postoperative (P = .002) immunosuppressive therapy was found between the groups with complete healing/reduction and no improvement/aggravation. This systematic review finds the current evidence on efficacy and safety of skin grafting in treatment of PG and PVU to be promising but limited to the size and lack of studies superior to case reports and case series. Future placebo‐controlled trials are required to draw a stronger conclusion.

show abstract

Vasculitic Ulcers

Cited by 24 publications

References 23 publications

Necrotic lower extremities ulcers caused by calciphylaxis in chronic renal failure patient

Necrotic lower extremities ulcers caused by calciphylaxis in chronic renal failure patient

Progress in Wound Healing: Wisdom Not Consumed in Confidence?

Efficacy and safety of skin grafting in treatment of vasculitic ulcer and pyoderma gangrenosum—A systematic review

Contact Info

Product

Resources

About