Vasoactive intestinal peptide mRNA and immunoreactivity are decreased in fetal alcohol syndrome model

Spong, Catherine Y.; Auth, Jonathan; Vink, Joy; Goodwin, Katie; Abebe, Daniel; Hill, Joanna M.; Brenneman, Douglas E.

doi:10.1016/s0167-0115(02)00104-0

Cited by 20 publications

(13 citation statements)

References 23 publications

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“…Our finding that blockage of VIP during mouse embryogenesis also results in microcephaly, growth restriction and developmental delays [26,72], suggests that an alcohol-induced imbalance of VIP during embryogenesis may account for some aspects of fetal alcohol syndrome. This concept is supported by additional studies in which alcohol exposure during embryonic day 8 in the mouse caused a reduction in VIP and VIP mRNA in the uterus (decidua, membranes and embryo) [146]. In this study, cotreatment with the active peptides of proteins ADNF and ADNP, which are regulated by VIP, prevented alcohol-induced fetal death and growth abnormalities [146].…”

Section: Vip In Fetal Alcohol Syndromesupporting

confidence: 59%

“…This concept is supported by additional studies in which alcohol exposure during embryonic day 8 in the mouse caused a reduction in VIP and VIP mRNA in the uterus (decidua, membranes and embryo) [146]. In this study, cotreatment with the active peptides of proteins ADNF and ADNP, which are regulated by VIP, prevented alcohol-induced fetal death and growth abnormalities [146]. There are other known links between VIP and alcohol.…”

Section: Vip In Fetal Alcohol Syndromesupporting

confidence: 57%

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Vasoactive Intestinal Peptide in Neurodevelopmental Disorders:Therapeutic Potential

Hill¹

2007

CPD

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Abstract:Vasoactive intestinal peptide (VIP) mediates important events during the development of the nervous system. VIP can stimulate neuronogenesis as well as differentiation and neurite outgrowth; it can promote the survival of neurons and assist in neuronal repair; it is also anti-inflammatory and can modulate immune responses. In addition, VIP is necessary for the normal growth and development of the early postimplantation mouse embryo during the period when the major embryonic events are neural tube formation, neuronogenesis and expansion of the vascular system. Receptors for VIP appear during early postimplantation embryogenesis in the rodent and exhibit changing localization patterns throughout the development of the brain. During embryogenesis, unregulated VIP may have major and permanent consequences on the formation of the brain and may be a participating factor in disorders of neurodevelopment. VIP has been linked to autism, Down syndrome and fetal alcohol syndrome. This paper will review the role of VIP in neurodevelopment, its known involvement in neurodevelopmental disorders and propose ways in which VIP might be of therapeutic value.

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Section: Vip In Fetal Alcohol Syndromesupporting

confidence: 59%

Section: Vip In Fetal Alcohol Syndromesupporting

confidence: 57%

Vasoactive Intestinal Peptide in Neurodevelopmental Disorders:Therapeutic Potential

Hill¹

2007

CPD

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“…Moreover, Spong et al [24] have documented, in a mouse model of fetal alcohol syndrome, that alcohol treatment caused a decrease in VIP expression in the fetal cortex. If such changes in VIPcontaining neurons and VIP expression persist into adulthood, the resultant decrease in perivascular VIP levels could potentially cause a compensatory augmentation in vascular VIP receptor density or sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…Fetal alcohol exposure leads to a permanent decrease in VIP levels in the mouse fetal cortex [24] . Another study from our laboratory also suggests that fetal alcohol exposure decreases neuronal VIP expression in the near-term fetal sheep [Anderson et al: Dev Neurosci 2007;5: in press].…”

Section: Introductionmentioning

confidence: 99%

Fetal Alcohol Exposure Alters Cerebrovascular Reactivity to Vasoactive Intestinal Peptide in Adult Sheep

et al. 2007

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Chronic fetal alcohol exposure impairs neural and vascular development. We have previously shown that fetal alcohol exposure is associated with attenuated hypoxic cerebral vasodilation and reduced neuronal vasoactive intestinal peptide (VIP) expression in fetal sheep. In the present study, we tested the hypothesis that fetal alcohol exposure alters vascular development, leading to altered cerebral vascular reactivity to VIP in adulthood. Penetrating intracerebral arterioles were harvested from the brains of adult (10–13 months old) offspring of ewes that had received intravenous infusions of alcohol (1.5 g/kg) or same-volume saline (90 min/day, 5 days/week) during days 30–82 of gestation (full term = 145 days). The isolated arterioles were cannulated with a micropipette system that allowed luminal perfusion and control of luminal pressure and developed spontaneous tone at 40°C and 60 mm Hg luminal pressure. There was no difference in myogenic tone between arterioles exposed prenatally to alcohol (n = 18) and saline controls (n = 17). However, fetal alcohol exposure significantly (p = 0.03) enhanced the dilator responses of adult intracerebral arterioles to VIP [0.1 nM to 1 µM, logEC₅₀: –8.6 ± 0.2 (alcohol) vs. –7.4 ± 0.8 (saline)]. In contrast, there was no difference in dilator responses to H⁺ (pH 6.8 buffer), to adenosine (10 nM to 0.1 mM), or to CGS21680 (an adenosine A_2A receptor agonist, 0.01 nM to 10 µM). Thus, fetal alcohol exposure alters vasomotor sensitivity to VIP in adult intracerebral arterioles – perhaps a compensatory response to alcohol-induced underdevelopment of neurotransmitter pathways involved in cerebral vascular regulation.

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“…While alternative splice variants of the PAC1 receptor have been associated with VIP neuroprotective activity (Pilzer and Gozes 2006). Interestingly, a peptide mixture including NAP and the related peptide SALLRSIPA induced increases in VIP mRNA, suggesting potential feedback regulation (Spong et al 2002).…”

Section: Editorial: From the Desk Of The Editor-in-chiefmentioning

confidence: 99%

VIP–PACAP 2010: My Own Perspective on Modulation of Cognitive and Emotional Behavior

Gozes

2010

J Mol Neurosci

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Vasoactive intestinal peptide mRNA and immunoreactivity are decreased in fetal alcohol syndrome model

Cited by 20 publications

References 23 publications

Vasoactive Intestinal Peptide in Neurodevelopmental Disorders:Therapeutic Potential

Vasoactive Intestinal Peptide in Neurodevelopmental Disorders:Therapeutic Potential

Fetal Alcohol Exposure Alters Cerebrovascular Reactivity to Vasoactive Intestinal Peptide in Adult Sheep

VIP–PACAP 2010: My Own Perspective on Modulation of Cognitive and Emotional Behavior

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