Vasoactive Intestinal Peptide-Secreting Pheochromocytoma: A Case Report and Review of Literature

Yee, Shelby; Meyer, John H.

doi:10.1016/j.aace.2022.03.003

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…While the classic symptoms of sympathetic PPGL are generally associated with catecholamine excess, PPGLs may also secrete neuropeptides in some cases. For example, cortisol excess caused by adrenocorticotrophic hormone (ACTH) or corticotrophin releasing hormone (CRH) secretion by phaeochromocytoma [10,11] has been described as has symptomatic vasoactive intestinal peptide (VIP) [12,13] and growth hormone-releasing hormone (GHRH) [14] secretion. The key synthetic enzymes that may be expressed by PPGL are tyrosine hydroxylase (TH), dopamine β-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT).…”

Section: Biochemical and Genetic Characteristics Of Ppglmentioning

confidence: 99%

A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma

Boot

2023

Diagnostics

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Phaeochromocytomas (PC) and sympathetic paragangliomas (PGL) are potentially malignant tumours arising from the adrenal medulla (PC) or elsewhere in the sympathetic nervous system (PGL). These tumours usually secrete catecholamines and are associated with significant morbidity and mortality, so accurate and timely diagnosis is essential. The initial diagnosis of phaeochromocytoma/paraganglioma (PPGL) is often dependent on biochemical testing. There is a range of pre-analytical, analytical and post-analytical factors influencing the analytical and diagnostic performance of biochemical tests for PPGL. Pre-analytical factors include patient preparation, sample handling and choice of test. Analytical factors include choice of methodology and the potential for analytical interference from medications and other compounds. Important factors in the post-analytical phase include provision of appropriate reference ranges, an understanding of the potential effects of various medications on metanephrine concentrations in urine and plasma and a consideration of PPGL prevalence in the patient population being tested. This article reviews these pre-analytical, analytical and post-analytical factors that must be understood in order to provide effective laboratory services for biochemical testing in the diagnosis of PPGL.

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Section: Biochemical and Genetic Characteristics Of Ppglmentioning

confidence: 99%

A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma

Boot

2023

Diagnostics

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“…For more details, please access ACCR online journal available at https://www.aaceclinicalcasereports.com/ Under the Pituitary-Gonadal-Adrenal Access in this issue, authors described an interesting case of composite vasoactive intestinal peptide (VIP)-secreting pheochromocytoma. 1 Another report illustrates a rare case of hypercortisolism remission due to apoplexy of sparsely granulated corticotroph tumor with subsequent central adrenal insufficiency, hypothyroidism, and hypogonadism. 2 Authors also described the diagnosis and management of adrenal crisis precipitated by COVID-19 messenger RNA vaccination in a patient with hypopituitarism.…”

Section: Dear Colleaguesmentioning

confidence: 99%

Editorial for July/August Issue of AACE Clinical Case Reports

Jasim¹

2022

AACE Clinical Case Reports

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Two Cases of Composite Pheochromocytoma-Ganglioneuromas With Plasma Metanephrine Levels in the Subclinical Range Pheochromocytoma-Ganglioneuroma

Najjar,

Naous,

Blake

et al. 2024

AACE Clinical Case Reports

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Vasoactive Intestinal Peptide-Secreting Pheochromocytoma: A Case Report and Review of Literature

Cited by 4 publications

References 18 publications

A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma

A Laboratory Medicine Perspective on the Investigation of Phaeochromocytoma and Paraganglioma

Editorial for July/August Issue of AACE Clinical Case Reports

Two Cases of Composite Pheochromocytoma-Ganglioneuromas With Plasma Metanephrine Levels in the Subclinical Range Pheochromocytoma-Ganglioneuroma

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