Vasoactive Peptides Modulate Vascular Endothelial Cell Growth Factor Production and Endothelial Cell Proliferation and Invasion

Pedram, Ali; Razandi, Mahnaz; Hu, Renming; Levin, Ellis R.

doi:10.1074/jbc.272.27.17097

Cited by 177 publications

(125 citation statements)

References 62 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…TSH downregulates ANP receptor number (Tseng et al 1991) in human thyroid cells but there are no data on the regulation of ANP expression. In endothelial cells, both ANP and ET-1 regulate VEGF synthesis, ANP being inhibitory whereas ET-1 is stimulatory (Pedram et al 1997). In this way, these vasoactive peptides can effect a close regulation of endothelial cell proliferation and invasion.…”

Section: ) and Frtl-5 Cells (Vainiomentioning

confidence: 99%

Growth factors and goitrogenesis

Bidey¹,

Hill²,

Eggo³

1999

Journal of Endocrinology

View full text Add to dashboard Cite

By combining data from studies of multinodular non-toxic goitre (MNTG) with data from rat models of goitre induction and in vitro models, a map of the growth factors involved in goitrogenesis has been constructed. We have addressed the roles of the insulin-like growth factors, transforming growth factors, fibroblast growth factors, endothelins, etc. We hypothesise that an imbalance in the interactions between the various growth factor axes exists in MNTG which favours cell replication. Thyrotrophin, although not significantly elevated in MNTG, exerts critical effects through interactions with autocrine and paracrine factors and their receptors. Expansion of the thyroidal vascular bed through angiogenesis is closely co-ordinated with follicular cell expansion and folliculoneogenesis, and while the integrated paracrine actions of fibroblast growth factors, vascular endothelial growth factor and endothelin probably play central roles, additional, as yet elusive, factors are probably involved. The combination of in vitro and in vivo approaches, designed to address specific questions, will undoubtedly continue to prove invaluable in dissecting further the complex interactions that exist between these growth factors, their binding proteins and receptors in goitrogenesis.

show abstract

Section: ) and Frtl-5 Cells (Vainiomentioning

confidence: 99%

Growth factors and goitrogenesis

Bidey¹,

Hill²,

Eggo³

1999

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Furthermore, ET-1 potentiates the effect of several proangiogenic factors in vitro, including PDGF and VEGF (Pedram et al, 1997;Yang et al, 1999). ET-1 also stimulates invasion and morphological differentiation of human umbilical vein endothelial cells (HUVEC) in matrigel in vitro, and this may be facilitated via ET-1-induced production of matrix metalloproteinase-2 (MMP-2) by endothelial cells (Salani et al, 2000b).…”

Section: Endothelin and Angiogenesismentioning

confidence: 99%

“…ET-1 is a potent mitogen for both endothelial cells and vascular smooth muscle cells (VSMC) in vitro (Komuro et al, 1988;Pedram et al, 1997). In addition, ET-1 may indirectly enhance endothelial cell proliferation through stimulation of vascular endothelial growth factor (VEGF) production by other cell types (Pedram et al, 1997;Salani et al, 2000a).…”

Section: Endothelin and Angiogenesismentioning

confidence: 99%

Endothelin-1: a multifunctional molecule in cancer

2003

View full text Add to dashboard Cite

show abstract

“…With respect to ET receptors, predominantly ET A R mediates tumour-associated functions, whereas there is less evidence for ET B R-dependent tumour-related functions (Grant et al, 2003;Nelson et al, 2003). Engagement of ET A -receptor by ET-1 triggers tumorigenesis and tumour progression by activation of tumour proliferation, invasion, angiogenesis, and inhibition of apoptosis (Pedram et al, 1997;Bagnato and Catt, 1998;Bagnato et al, 1999;Eberl et al, 2000b;Salani et al, 2000;Rosano et al, 2001;Del Bufalo et al, 2002). There is also evidence for an autocrine and/or paracrine mechanism of action of ET-1 including angiogenesis-promoting effects in malignant tissues.…”

mentioning

confidence: 99%

Expression of Endothelin-A-Receptor predicts unfavourable response to neoadjuvant chemotherapy in locally advanced breast cancer

et al. 2004

View full text Add to dashboard Cite

Endothelin-1 (ET-1) and its receptors (ET A R and ET B R), referred to as the endothelin (ET) axis, are overexpressed in breast carcinomas and appear to influence tumour growth and progression. The objective of this study was to determine the effect of expression of the ET axis in breast carcinomas on response to cytotoxic chemotherapy. The study included 44 patients with locally advanced breast cancer participating in a prospective phase III study evaluating high-dose neoadjuvant chemotherapy of epirubicin and cyclophosphamide. Expression of ET-1, ET A R and ET B R was determined by semiquantitative immunohistochemical analysis of breast cancer tissue from prechemotherapy tru-cut biopsies. Immunohistochemical staining was positive for ET-1 in 61.5%, for ET A R in 35% and for ET B R in 35.9% of breast carcinomas. Pathological response to chemotherapy was significantly decreased in ET A Rpositive patients (P ¼ 0.002). In total, 50% of ET A R-positive patients as compared to 7.7% of ET A R-negative patients attained pathologically 'no change'. Logistic regression confirmed ET A R as an independent predictive marker for pathological response (P ¼ 0.009). These data indicate that increased expression of ET A R in breast carcinomas is associated with resistance to chemotherapy. Determination of ET A R status may serve as a predictive marker for identifying patients less likely to be responsive to conventional chemotherapy.

show abstract

Vasoactive Peptides Modulate Vascular Endothelial Cell Growth Factor Production and Endothelial Cell Proliferation and Invasion

Cited by 177 publications

References 62 publications

Growth factors and goitrogenesis

Growth factors and goitrogenesis

Endothelin-1: a multifunctional molecule in cancer

Expression of Endothelin-A-Receptor predicts unfavourable response to neoadjuvant chemotherapy in locally advanced breast cancer

Contact Info

Product

Resources

About