Vasodilation and hypotension of a novel 3-benzylquinazolin- 4(3H)-one derivative via the inhibition of calcium flux

Li, Sen; Zuo, Sai-Jie; Cao, Lei; Liu, Dongzheng; Zhang, San‐Qi; Cao, Yunxia

doi:10.1016/j.ejphar.2016.10.003

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…Hypertension is a significant risk factor for CVD. The pathogenesis of hypertension is commonly believed to involve endothelial dysfunction and increased peripheral vascular resistance [ 49 ]. Elkayam et al [ 50 ] discovered that the administration of 80 mg/kg/day of allicin for 6 weeks resulted in reduced systolic blood pressure in spontaneously hypertensive rats (SHRs).…”

Section: Allicin In the Treatment Of Cvdmentioning

confidence: 99%

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Gao,

Wang,

Qin

et al. 2024

Chin Med

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Cardiovascular disease (CVD) remains the predominant cause of mortality and disability worldwide. Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical research. Garlic (Allium sativum L.) is one of the oldest plants and is world-renowned for its dietary and medicinal values. Allicin (diallyl thiosulfinate) is one of the primary natural active ingredients in garlic, which has been proven to have powerful cardioprotective effects and mediate various pathological processes related to CVD, such as inflammatory factor secretion, myocardial cell apoptosis, oxidative stress, and more. Therefore, allicin holds a promising application prospect in the treatment of CVD. This review summarized the biological functions of allicin and its potential mechanisms in CVD, including antioxidation, anti-inflammation, and anti-apoptosis effects. Reckoning with these, we delved into recent studies on allicin’s cardioprotective effects concerning various CVDs, such as atherosclerosis, hypertension, myocardial infarction, arrhythmia, cardiac hypertrophy, heart failure, and cardiotoxicity. Further, considering the tremendous advancement in nanomedicine, nanotechnology-based drug delivery systems show promise in addressing limitations of allicin’s clinical applications, including improving its solubility, stability, and bioavailability. Through this review, we hope to provide a reference for further research on allicin in cardioprotection and drug development. Graphical Abstract

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Section: Allicin In the Treatment Of Cvdmentioning

confidence: 99%

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Gao,

Wang,

Qin

et al. 2024

Chin Med

View full text Add to dashboard Cite

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Remarkably flexible quinazolinones—synthesis and biological applications

Reddy

Sivaramakrishna

2019

Journal of Heterocyclic Chem

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Even though several quinazolinone derivatives have been synthesized, still there is a constant demand for designing and synthesis of new quinazolinone derivatives by fine‐tuning the electronic and steric properties of substituents due to their interesting structure‐based biological utilities and the versatile chemistry. While many of the synthetic routes are useful as building blocks in synthetic organic chemistry, the drawbacks of some of these methods like unsatisfactory or variable yields, prolonged reaction times, inadequate tolerance to other substrates, including the use of costly catalysts/reagents. This review article is mainly focused on various synthetic routes for the preparation of quinazolinones, their important properties and applications.

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Antihypertensive effects of allicin on spontaneously hypertensive rats via vasorelaxation and hydrogen sulfide mechanisms

Cui

Liu

Chen³

et al. 2020

Biomedicine & Pharmacotherapy

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Vasodilation and hypotension of a novel 3-benzylquinazolin- 4(3H)-one derivative via the inhibition of calcium flux

Cited by 5 publications

References 11 publications

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Remarkably flexible quinazolinones—synthesis and biological applications

Antihypertensive effects of allicin on spontaneously hypertensive rats via vasorelaxation and hydrogen sulfide mechanisms

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