Vasopressin affects the behavior of rats in a positively-rewarded discrimination task

Hostetter, Gayle; Jubb, Sharon L.; Kozlowski, Gerald P.

doi:10.1016/0024-3205(77)90014-5

Cited by 68 publications

(11 citation statements)

References 12 publications

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“…Although data from our laboratory demonstrated that VP enhanced the performance of normal Long-Evans rats in a positive reward, visual discrimination task [11], pre liminary experiments in a passive avoidance situation showed that VP did not uniformly improve retention. This lack of consistent effects of VP injections in addition to the results reported by Celestian et al [5] and Milter et al [14] in Brattleboro rats indicated to us that a systematicinvestigation of the influence of VP on avoidance behavior was warranted.…”

mentioning

confidence: 99%

An Inability of Subcutaneous Vasopressin to Affect Passive Avoidance Behavior

Hostetter

Jubb

Kozlowski³

1980

Neuroendocrinology

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The effects of subcutaneous injections of vasopressin on the passive avoidance behavior of rats were investigated in an extensive study. 200 male Wistar rats were tested in a step-through passive avoidance task. The animals were assigned randomly to 1 of 20 experimental groups consisting of five vasopressin injection and four shock level conditions. Each animal was trained to enter a dark compartment, then subjected to 0.25, 0.10, 0.05 mA or no foot shock for 2 sec. 60 min prior to a retention test administered 24 h after the foot shock, each animal was given a single injection of 0.30, 0.12, 0.06, or 0.03 IU of vasopressin or of saline. Time to reenter the shock compartment was tested 24 and 48 h after the foot shock. Latencies in both retention tests indicated that, although there was a significant effect of shock level on latency scores, there was no effect of vasopressin with any dose level tested. The inability to find an effect of vasopressin in this study is contrary to results of other studies. Several factors, including general reactivity of the animals or the distribution system for vasopressin in the brain, might provide the underlying reason for these dramatic differences.

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confidence: 99%

An Inability of Subcutaneous Vasopressin to Affect Passive Avoidance Behavior

Hostetter

Jubb

Kozlowski³

1980

Neuroendocrinology

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“…The present datado notsupportthe viewthat DG-AVP affects the reinforcing properties of food. Vasopressin has been shown to have weak and inconsistent effects on visual and spatial discrimination tasks (Alliot & Alexinsky, 1982;Bohus, 1977;Hostetter et al, 1977;Sara et al, 1982). Meek (1983) recently showed that vasopressinincreases the rate of acquisitionof a temporal discrimination in a two-lever psychophysical procedure.…”

Section: Discussionmentioning

confidence: 99%

Effects of vasopressin on multiple fixed-ratio fixed-interval schedules of reinforcement

Cohen

Knight

Tamminga

et al. 1985

Bull. Psychon. Soc.

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The effect of arginine-and des-glycinamide arginine vasopressin on steady-state operant responding was examined. Rats were trained to press a lever for food under a multiple fixed-interval 4-min fixed -ratio 30 schedule of reinforcement. Arg vasopressin (0.5 to 100jLg/kg , subcutaneous) produced a dose-dependent decrease in response rate, but des-glycinamide arginine vasopressin (0.5 to lOOjLg/kg, subcutaneous) had no effect. Neither peptide sign ificantly altered fixed-interval response patterning. These data suggest that vasopressin 's behavioral effects should be viewed in light of its aversive peripheral act ions.

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“…Hostetter et al . found no effect of vasopressin in a food reward task but did find an effect on fear‐motivated behavior; they subsequently reported the inability to reproduce de Wied's findings on passive avoidance behavior . In 1983, Ettenberg et al .…”

Section: The Critical Assaultmentioning

confidence: 96%

The vasopressin−memory hypothesis: a citation network analysis of a debate

Leng

Maclean

2019

Annals of the New York Academy of Sciences

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The 1970s saw a growing interest in the vasopressin−memory hypothesis, proposed by David de Wied and his collaborators in Utrecht. This rose to a peak in the 1980s that saw a flurry of papers published from diverse sources critical of the experimental foundations of this idea. In subsequent years, interest in this hypothesis declined markedly as shortcomings were recognized. Here, we study this debate using citation network analysis to identify the influential papers in this debate and the citation links between them. The issues raised have contemporary relevance to the current controversy about the interpretation of studies using intranasal oxytocin.

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Vasopressin affects the behavior of rats in a positively-rewarded discrimination task

Cited by 68 publications

References 12 publications

An Inability of Subcutaneous Vasopressin to Affect Passive Avoidance Behavior

An Inability of Subcutaneous Vasopressin to Affect Passive Avoidance Behavior

Effects of vasopressin on multiple fixed-ratio fixed-interval schedules of reinforcement

The vasopressin−memory hypothesis: a citation network analysis of a debate

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