Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides

Glavaš, Mladena; Gitlin-Domagalska, Agata; Dębowski, Dawid; Ptaszyńska, Natalia; Łęgowska, Anna; Rolka, Krzysztof

doi:10.3390/ijms23063068

Cited by 34 publications

(16 citation statements)

References 221 publications

(291 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A small proportion of the drug is eliminated unchanged in urine ( 4 ). Of the three other synthetic analogs of ADH, desmopressin is the most used synthetic analog of ADH to treat central diabetes insipidus (DI), which acts more specifically on V2 receptors than V1a ( 7 ).…”

Section: Physiology and Pharmacologymentioning

confidence: 99%

Vasopressin Use in the Support of Organ Donors: Physiological Rationale and Review of the Literature

Ouerd

Frenette

Serri

et al. 2023

Critical Care Explorations

View full text Add to dashboard Cite

show abstract

Section: Physiology and Pharmacologymentioning

confidence: 99%

Vasopressin Use in the Support of Organ Donors: Physiological Rationale and Review of the Literature

Ouerd

Frenette

Serri

et al. 2023

Critical Care Explorations

View full text Add to dashboard Cite

show abstract

“…AVP (vasotocin in birds [ 18 ] and lypressin, which contains lysine instead of arginine, in pigs [ 19 ]) is a nonapeptide. As a hormone, it is released into the general circulation from the posterior pituitary and forms the peripheral vasopressinergic system, which is also called the hypothalamic–neurohypophyseal system [ 20 ].…”

Section: Vasopressinmentioning

confidence: 99%

Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems

Török

Várga

Zelena

2022

IJMS

View full text Add to dashboard Cite

Normal biological rhythms, including sleep, are very important for a healthy life and their disturbance may induce—among other issues—memory impairment, which is a key problem of many psychiatric pathologies. The major brain center of circadian regulation is the suprachiasmatic nucleus, and vasopressin (AVP), which is one of its main neurotransmitters, also plays a key role in memory formation. In this review paper, we aimed to summarize our knowledge on the vasopressinergic connection between sleep and memory with the help of the AVP-deficient Brattleboro rat strain. These animals have EEG disturbances with reduced sleep and impaired memory-boosting theta oscillation and show memory impairment in parallel. Based upon human and animal data measuring AVP levels, haplotypes, and the administration of AVP or its agonist or antagonist via different routes (subcutaneous, intraperitoneal, intracerebroventricular, or intranasal), V1a receptors (especially of hippocampal origin) were implicated in the sleep-memory interaction. All in all, the presented data confirm the possible connective role of AVP between biological rhythms and memory formation, thus, supporting the importance of AVP in several psychopathological conditions.

show abstract

“…Vasopressin (AVP) is a neurotransmitter secreted by ~20% of SNC neurons, and AVP neurons are important components of circadian pacemaker ( 147 – 149 ). CLOCK/BMAL1 complex binds the AVP (ID:551) promoter region and induces AVP synthesis ( 150 , 151 ), while CRY1 and CRY2 repress it ( 152 ).…”

Section: The Circadian System: An Orchestra Of Signals Synchronizes F...mentioning

confidence: 99%

Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises

Senesi

Ferrulli²,

Luzi³

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

Circadian rhythm, an innate 24-h biological clock, regulates several mammalian physiological activities anticipating daily environmental variations and optimizing available energetic resources. The circadian machinery is a complex neuronal and endocrinological network primarily organized into a central clock, suprachiasmatic nucleus (SCN), and peripheral clocks. Several small molecules generate daily circadian fluctuations ensuring inter-organ communication and coordination between external stimuli, i.e., light, food, and exercise, and body metabolism. As an orchestra, this complex network can be out of tone. Circadian disruption is often associated with obesity development and, above all, with diabetes and cardiovascular disease onset. Moreover, accumulating data highlight a bidirectional relationship between circadian misalignment and cardiometabolic disease severity. Food intake abnormalities, especially timing and composition of meal, are crucial cause of circadian disruption, but evidence from preclinical and clinical studies has shown that food could represent a unique therapeutic approach to promote circadian resynchronization. In this review, we briefly summarize the structure of circadian system and discuss the role playing by different molecules [from leptin to ghrelin, incretins, fibroblast growth factor 21 (FGF-21), growth differentiation factor 15 (GDF15)] to guarantee circadian homeostasis. Based on the recent data, we discuss the innovative nutritional interventions aimed at circadian re-synchronization and, consequently, improvement of cardiometabolic health.

show abstract

Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides

Cited by 34 publications

References 221 publications

Vasopressin Use in the Support of Organ Donors: Physiological Rationale and Review of the Literature

Vasopressin Use in the Support of Organ Donors: Physiological Rationale and Review of the Literature

Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems

Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises

Contact Info

Product

Resources

About