Vasopressin during cardiopulmonary resuscitation: A progress report

Krismer, Anette C.; Wenzel, Volker; Stadlbauer, Karl H.; Mayr, Viktoria D.; Lienhart, H.; Arntz, H.-R.; Lindner, Karl H.

doi:10.1097/01.ccm.0000134267.91520.c0

Cited by 46 publications

(29 citation statements)

References 36 publications

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“…Nevertheless, to date, there have only been a small number of randomized controlled trials of VP in humans. Furthermore, whether these data will translate into improved longterm outcome is not known [12]. The most possible adverse effect of VP administration may be coronary vasoconstriction, although this is still controversial [12].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, whether these data will translate into improved longterm outcome is not known [12]. The most possible adverse effect of VP administration may be coronary vasoconstriction, although this is still controversial [12]. There is no doubt that effective treatment of vasodilatory shock is possible if patients possess normal cardiac performance and are maintained by adequate intravascular volume replacement.…”

Section: Discussionmentioning

confidence: 99%

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Low-dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia

et al. 2005

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We report the successful use of a low-dose vasopressin (VP) infusion to recover a hypotensive crisis in patients who suffered persistent hypotension after prolonged hemorrhage during general anesthesia. VP was infused in two posthemorrhagic vasodilatory shock patients when they remained persistently hypotensive despite adequate fluid resuscitation and infusions of pharmacological doses of catecholamines. On administration of VP at 0.04 U x min(-1), systemic vascular resistance, systolic arterial pressure, and urine output were immediately increased (as compared with the values obtained just before VP), and infusion of catecholamine could be decreased. No adverse cardiac effects were observed during VP infusions in these patients. During vasodilatory shock after prolonged and severe hemorrhage, VP seems to be effective in reversing hypotension and decreasing the need for exogenous cathecholamines while preserving cardiac function and critical organ blood flow.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low-dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia

et al. 2005

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“…12,13) Clinical studies have shown that patients with heart failure have chronically elevated plasma AVP levels, which may contribute to fluid retention. 12,14) Because AVP has adverse effects on heart failure, AVP activity in the myocardium and coronary vasculature may be influenced by an intrinsic cardiac AVP system.…”

Section: Introductionmentioning

confidence: 99%

Nonapeptide Hormones Oxytocin and Vasopressin Distinctly Regulate CaV1.2 L-type Calcium Channel Expression in Cardiomyocytes

et al. 2010

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Background: The neurohypophyseal hormones oxytocin (OT) and [Arg 8 ]-vasopressin (AVP) have recently been implicated in cardiac function. This study was designed to investigate actions of OT and AVP on regulation of the voltage-gated Ca 2þ channel in cardiomyocytes.Methods and Results: Cultured neonatal rat cardiomyocytes were stimulated with OT or AVP (10 À8 M to 10 À6 M) for 24-72 h, followed by real-time PCR and patch clamp studies. Although OT did not exert any modulatory effect on L-type Ca 2þ channel current, as a shortterm effect, stimulation of cardiomyocytes with OT but not AVP decreased the expression of Ca V 1.2 mRNA with a reduced L-type Ca 2þ channel current. A transcription factor CREB mRNA expression was down-regulated by OT treatment, although T-type Ca 2þ channels (Ca V 3.1, Ca V 3.2) were unaffected by OT or AVP.Conclusion: OT but not AVP down-regulates L-type Ca 2þ channel expression through the inhibition of CREB transcriptional, suggesting a novel mechanism of OT action in the cardiac electrophysiology. (J Arrhythmia 2010; 26: 111-118)

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“…(8)(9)(10) Vasopressin is a potent vasopressor with extended purposes in the treatment of severe trauma, septic shock, cardiac diseases and during cardiopulmonary resuscitation. (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) In addition, a few researchers have found that vasopressin is absorbed well via the mucosa of the airway and alveoli. (23)(24)(25) The combination of a LMA and vasopressin could be a practical management tool in pre-hospital settings.…”

Section: Introductionmentioning

confidence: 99%

The feasibility of vasopressin administration via laryngeal mask airway using a porcine model

Chen

Liao

Hsu

et al. 2016

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Vasopressin during cardiopulmonary resuscitation: A progress report

Abstract: According to new data from the European vasopressin study, we suggest, first, the administration of 1 mg of epinephrine, followed alternately by 40 IU of vasopressin and 1 mg of epinephrine every 3 mins in adult cardiac arrest victims, regardless of the initial electrocardiographic rhythm.

Cited by 46 publications

References 36 publications

Low-dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia

Low-dose vasopressin infusion in patients with severe vasodilatory hypotension after prolonged hemorrhage during general anesthesia

Nonapeptide Hormones Oxytocin and Vasopressin Distinctly Regulate CaV1.2 L-type Calcium Channel Expression in Cardiomyocytes

The feasibility of vasopressin administration via laryngeal mask airway using a porcine model

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