Vasopressin-lnduced Amber-Like Skin Necrosis

Abstract

Case reports about vasopressin-induced cutaneous necrosis are not frequent. Here we report a further case, of which skin manifestations included not only mottling, cyanosis, ecchymosis, bullae and gangrene, but also amber-like change in focal areas. Besides, intermittent paling of the skin with or without deep pain sensation of the limbs over non-injection sites was observed that might be a warning sign of impending skin necrosis. Based on the literature about vasopressin-induced skin necrosis we discuss the possible role of coagulation enhancement of this molecule.

Widespread cutaneous necrosis occurring in association with the antiphospholipid syndrome: a report of two cases

“… 4 WCN has been reported in association with a number of pathological processes including meningococcal septicaemia, 5 protein C and S deficiencies, 6 calciphylaxis (vascular calcification–cutaneous necrosis syndrome), 7 cold agglutinins 8 and drugs such as heparin, warfarin, vasopressin, interferon‐α2b and interferon‐β1b. 9–13 Recent interest in the thrombogenic effects of aPL has resulted in a number of reports of WCN occurring as a consequence of dermal microvascular thrombosis in the antiphospholipid syndrome. 14–22 …”