Vasopressin maintains long-term potentiation in rat lateral septum slices

Hooff, Peter van den; Urban, I.J.A.; Wied, D. de

doi:10.1016/0006-8993(89)91440-6

Cited by 51 publications

(16 citation statements)

References 29 publications

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“…presumably, physiologically significant action of these peptides in the brain may be complementary to LTP, increasing transmission plasticity in those brain structures that are innervated by VP-releasing fibers. The facilitation by VP of I,TP expres-sion in the lateral septum [69] and the electron microscopic finding of vasopressin-containing synapses in the close vicinity of glutamate-containing terminals of the fimbria fibers on dendrites of the lateral septum neurons [27] support this notion.…”

Section: Discussionmentioning

confidence: 71%

“…These findings suggested that the brain VP and/or its metabolites may function as a long-acting principle, facilitating the neuronal responses to an excitatory, glutamatergic input [64]. The long-lasting facilitation by 0.1 nM vasopressin of the excitatory postsynaptic potentials (EPSPs) in lateral septum neurons, evoked by stimulating the fimbria fibers [69], supports this notion. However, the action of picomolar concentrations of VP and VP(4-8) on the excitability and glutamatergic transmission of neurons in the ventral hippocampus has not yet been investigated, although some data for the dorsal hippocampus have been recently published [12,52].…”

Section: Introductionmentioning

confidence: 80%

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Long-lasting enhancement of synaptic excitability of CA1/subiculum neurons of the rat ventral hippocampus by vasopressin and vasopressin(4–8)

Chepkova¹,

French

Wied

et al. 1995

Brain Research

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Vasopressin (VP) is axonally distributed in many brain structures, including the ventral hippocampus. Picogram quantities of VP injected into the hippocampus improve the passive avoidance response of rats, presumably by enhancing memory processes. Vasopressin is metabolized by the brain tissue into shorter peptides, such as [pGlu4,Cyt~']VP(4-9) and [pGlu4,Cyt~']VP(4-8), which preserve the behavioral activity but lose the peripheral activities of the parent hormone. Using brain slices, we investigated whether VP or VP(4-8) affects excitatory postsynaptic potentials (EPSPs) and/or membrane responses to depolarization in neurons of the CA 1/subiculum of lhe ventral hippocampus. The EPSPs were evoked by stimulating the stratum radiatum of the CAI field; the membrane responses were elicited by current injections. Exposure of slices for 15 min to 0.1 nM solution of these peptides resulted in an increase in the amplitude and slope of the EPSPs in 21 neurons (67%) tested. No consistent change in either the resting membrane potential or the input resistance of the neurons was observed. The peptide-induced increase in EPSPs reached a maximum 30-45 min after peptide application. In 14 of these neurons (66%), the peptide-induced increase in EPSPs remained throughout the entire 60-120 min washout period. In the remaining 7 neurons (33%1, the initial increase in EPSPs amplitude was followed by a gradual decline to the pre-adminislralion level. The increase in EPSP amplitude was often, but not always, associated with a decrease in the threshold and increase in the number of action potentials in response lo depolarizing current injection. Suppression of GABA a receptor-mediated inhibition and N-methyl-D-aspartate (NMDA) receptor-mediated excitation did not prevent the effects of VP and VP(4-8) on the EPSP amplitude or the threshold for action potentials. The results demonstrate that 0.1 nM concentrations of these neuropeptides can elicit a long-lasting enhancement of the excitability of CAl/subiculum neurons of the ventral hippocampus to excitatory, glutamatergic synaptic input. This novel action of VP and its metabolite in the ventral hippocampus may be the physiological action, mediating the memory-enhancing effect of these peptides.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 80%

Long-lasting enhancement of synaptic excitability of CA1/subiculum neurons of the rat ventral hippocampus by vasopressin and vasopressin(4–8)

Chepkova¹,

French

Wied

et al. 1995

Brain Research

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“…In line with this, a pharmacological study has previously shown that pretraining intra-LS infusions of vasopressin, which is known both to increase HPC-LS glutamatergic neurotransmission and to facilitate the maintenance of LTP in the LS (Raggenbass et al 1988;Van Den Hooff et al 1989;Van Den Hooff and Urban 1990), not only spared fear conditioning to a tone CS that was fully predictive for the occurrence of the US (CS-US pairing), but promoted such elemental conditioning when the tone CS was not predictive for the occurrence of the US (CS -US unpairing). Concomitantly, infusion of vasopressin into the LS was associated with an impairment of contextual fear conditioning.…”

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confidence: 67%

Switching from contextual to tone fear conditioning and vice versa: The key role of the glutamatergic hippocampal-lateral septal neurotransmission

Calandreau¹,

Desgranges²,

Jaffard³

et al. 2010

Learn. Mem.

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International audienceThe aim of the present experiment was to directly assess the role of the glutamatergic hippocampal-lateral septal (HPC-LS) neurotransmission in tone and contextual fear conditioning. We found that pretraining infusion of glutamatergic acid into the lateral septum promotes tone conditioning and concomitantly disrupts contextual conditioning. Infusion of glutamatergic antagonist, on the contrary, promotes contextual conditioning to the detriment of tone fear conditioning. These findings highlight the direct contribution of the glutamatergic HPC-LS neurotransmission to the adaptive selection among environmental stimuli of those that best predict the occurrence of the aversive event

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“…To the best of our knowledge, there has been no study reporting effects of lateral septal VP manipulations on shock-probe burying behavior. Suggestions that VP might mediate spatial learning as well originate from studies on long-term potentiation (LTP [17,46]), an experimental model thought to underlie the cellular processes of memory formation. It was shown that VP maintained LTP and facilitated excitatory transmission in septal brain slices, whereas this maintenance was prevented by an antagonist of the V 1a receptor [22,45,46].…”

Section: Introductionmentioning

confidence: 99%

“…Suggestions that VP might mediate spatial learning as well originate from studies on long-term potentiation (LTP [17,46]), an experimental model thought to underlie the cellular processes of memory formation. It was shown that VP maintained LTP and facilitated excitatory transmission in septal brain slices, whereas this maintenance was prevented by an antagonist of the V 1a receptor [22,45,46]. However, in vivo experiments using microdialysis have shown that VP administration into the mediolateral septum impaired spatial learning, while VP antagonism left acquisition behavior undisturbed [11].…”

Section: Introductionmentioning

confidence: 99%

Differential modulation of lateral septal vasopressin receptor blockade in spatial learning, social recognition, and anxiety-related behaviors in rats

Everts

Koolhaas

1999

Behavioural Brain Research

140

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The role of lateral septal vasopressin (VP) in the modulation of spatial memory, social memory, and anxiety-related behavior was studied in adult, male Wistar rats. Animals were equipped with osmotic minipumps delivering the VP-antagonist d(CH2)5-DTyr(Et)VAVP (1 ng/0.5 vl per h) bilaterally into the lateral septum (LS). Subsequently, all rats were subjected to four behavioral tests. First, animals were tested in a spatial learning paradigm (Morris water maze; 12 trials), followed by the social recognition test. A possible role for VP in anxiety-related behavior was then studied in the shock-probe burying test and the elevated plus-maze, respectively. The results showed that VP receptor antagonism impaired social recognition and reduced open-arm activity in the plus-maze, while it had no effect on spatial learning (Morris maze) and shock-probe burying behavior. The results indicate a strong task-dependent specificity of lateral septal VP functioning.

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Vasopressin maintains long-term potentiation in rat lateral septum slices

Cited by 51 publications

References 29 publications

Long-lasting enhancement of synaptic excitability of CA1/subiculum neurons of the rat ventral hippocampus by vasopressin and vasopressin(4–8)

Long-lasting enhancement of synaptic excitability of CA1/subiculum neurons of the rat ventral hippocampus by vasopressin and vasopressin(4–8)

Switching from contextual to tone fear conditioning and vice versa: The key role of the glutamatergic hippocampal-lateral septal neurotransmission

Differential modulation of lateral septal vasopressin receptor blockade in spatial learning, social recognition, and anxiety-related behaviors in rats

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