Vasorelaxant activity of 7-β-O-glycosides biosynthesized from flavonoids

Penso, Juliana; Cordeiro, Kelly Carolina Frauzino Araújo; Cunha, Carla Rosane Mendanha da; Castro, Patrícia; Martins, Daniella Regina Arantes; Lião, Luciano M.; Rocha, Matheus Lavorenti; Oliveira, Valéria de

doi:10.1016/j.ejphar.2014.03.014

Cited by 14 publications

(10 citation statements)

References 49 publications

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“…Evidence from the literature may point to relevant contributions of some compounds detected. For example, quercetin and isorhamnetin were reported to reduce oxidative stress and to improve NO bioavailability, leading to the attenuation of endothelial dysfunction [29][30][31][32][33], and kaempferol is known to have a re-▶ Table 1 Phenolics content of the methanolic extract obtained from the sequential extraction of C. erythraea aerial parts a .…”

Section: Discussionmentioning

confidence: 99%

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

et al. 2019

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Centaurium erythraea is a plant used in traditional medicine for several cardiovascular disorders, namely hypertension, but there is no scientific evidence able to provide a molecular basis for its claimed antihypertensive effects. After a preliminary screen of extracts obtained from sequential extraction of C. erythraea aerial parts, effects of the methanolic fraction (MFCE) on changes in perfusion pressure of isolated rat mesenteric vascular bed (MVB) and in rat cardiac fibroblasts proliferation were investigated, gathering information on the mechanisms involved in endothelium-dependent effects and their dependence on a pro-proliferative stimulus. The HPLC-DAD determination of the phenolics content of MFCE revealed the presence of 22 phenolic compounds. MFCE reduced (63.3 ± 3.9%; n = 4) perfusion pressure in MVB and almost completely abrogated the Ang II-induced increase in cardiac fibroblasts proliferation. Reduction of the perfusion pressure caused by MFCE was endothelium-dependent and occurred in parallel with an increase in NO release. These effects were inhibited by muscarinic receptor antagonists, by L-NAME (a NO synthase inhibitor), and by ODQ (a soluble guanylate cyclase inhibitor). Experiments revealed that effects required the involvement of K+ channels, being inhibited by tetraethylamonium (TEA; a Ca2+ activated K+ channels inhibitor) and by glibenclamide (an ATP-sensitive K+ channels inhibitor). In conclusion, extracts from C. erythraea, particularly the compounds present in the MFCE, induce endothelium-dependent vasodilation and prevent fibroblast proliferation induced by angiotensin II, which can account for the claimed antihypertensive effects of C. erythraea in traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

et al. 2019

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“…Hypertension is an important public health problem and is one of the most common cardiovascular diseases [ 29 ]. Phenolic compounds, which perform antioxidant activity, have already been associated with coronary vasodilator activity [ 9 , 29 ]. This stresses the relevance of developing new specific antihypertensive drugs with potential for clinical use.…”

Section: Resultsmentioning

confidence: 99%

“…The possible mechanisms by which phenolic compounds perform cardiovascular activity have led to studies on free radical sequestration, inhibition of lipid peroxidation, and enzymatic activities [ 9 , 30 ]. Phenols also inhibit platelet aggregation and the oxidation of LDL cholesterol and promote vasodilation, thus ensuring the integrity of blood vessels [ 9 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

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Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats

et al. 2017

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This study identified two phenolic compounds in Schinus terebinthifolius Raddi fruits: naringenin (first report in this species) and gallic acid. Their structures were elucidated by nuclear magnetic resonance (NMR) data (1H-, 13C-NMR) and a high-performance liquid chromatography (HPLC) technique. A high content of phenolics (659.21 mg of gallic acid equivalents/g of sample—Folin-Ciocalteau method) and total flavonoids (140.69 mg of rutin equivalents/g of sample—aluminum chloride method) were quantified in S. terebinthifolius, as well as high antioxidant activity (77.47%—2,2-diphenyl-1-picrylhydrazyl, DPPH method). The antihypertensive activity related to its phenolic content was investigated. After intravenous infusion in Wistar rats, these phenolics significantly reduced (p < 0.05) the systolic, median, and diastolic arterial pressures of individuals. The rotarod test was performed to determine the mechanism of action of the sample vasorelaxant effect. It was found that its action exceeded that of the positive control used (diazepam). This confirmed the vasodilatory activity exerted by S. terebinthifolius fruits is related to the phenolic compounds present in the plant, which are potent antioxidants and inhibit oxidative stress, mainly in the central nervous system.

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“…Mechanisms of quercetin induced-vasodilation can be different in different vascular fields [27,28]. There are not pharmacological activities described for quercetin-3-O-pentosyl-glucoside and quercetin-3-glucuronyl-pentoside, but quercetin-3-O-glucoside was shown to induce relaxation of the rat aorta in an endothelium-independent manner [29].…”

Section: Discussionmentioning

confidence: 99%

The Hydroalcoholic Extract of Leaves of Mandevilla moricandiana Induces NO-Mediated Vascular Relaxation

et al. 2016

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Natural products extracted from plants represent a valuable source of new bioactive substances. Many studies describe the potential of plant products for the treatment of cardiovascular diseases. Species of the genus have been studied for their biological activities, mainly as antioxidant, anti-inflammatory, and vasorelaxant. However, the phytochemical and pharmacological profiles of have not been investigated yet. The aim of this study was to evaluate the vasodilator effect of the hydroalcoholic extract of the leaves of , as well as its chemical profile. Chemical analysis and quantification of major compounds were performed by HPLC analysis. Total flavonoid content was quantified based on rutin equivalents, and major compounds were identified based on HPLC-DAD-MS analysis. leaf extract-induced vasodilation was investigated in rat aortic rings precontracted with phenylephrine. The total flavonoids were quantified as 3.25 ± 0.11 % w/w of the hydroalcoholic leaf extract, and HPLC-DAD-MS allowed for the identification of luteolin and quercetin glycosides. The maximal relaxant effect of the hydroalcoholic leaf extract was 86.07 ± 1.68 % at a concentration of 30 µg/mL (p< 0.05; n = 6). The concentration of hydroalcoholic extract of the leaves of necessary to reduce phenylephrine-induced contractions of the endothelium-intact aorta by 50 % was 0.82 ± 0.10 µg/mL. leaf extract-induced vasodilation was abolished in aortas pretreated with NG-nitro-L-arginine methyl ester and 1H-[1,2,4]oxadiazolo-[4,3-]quinoxalin-1-one. In addition, diphenhydramine partially inhibited the effect of the hydroalcoholic extract of the leaves of . Thus,-induced relaxation depends on the endothelium and on the activation of the nitric oxide/cyclic GMP pathway, with the involvement of endothelial histamine H receptors. Luteolin and quercetin glycosides seem to contribute to the extract activity.

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Vasorelaxant activity of 7-β-O-glycosides biosynthesized from flavonoids

Cited by 14 publications

References 49 publications

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats

The Hydroalcoholic Extract of Leaves of Mandevilla moricandiana Induces NO-Mediated Vascular Relaxation

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