2022
DOI: 10.1155/2022/7257448
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Vasorelaxant and Antioxidant Effects of Aframomum pruinosum Gagnep. (Zingiberaceae) Seed Extracts May Mediate Their Cardioprotective Activity against Isoproterenol-Induced Myocardial Infarction

Abstract: Aframomum pruinosum seeds are traditionally used in Cameroon to treat cardiac palpitations. The present work evaluates the cardioprotective effects of the aqueous (AE) and ethanolic (EE) extracts from A. pruinosum seeds against isoproterenol-induced myocardial infarction. Male Wistar rats were pretreated for 14 days with AE or EE at doses of 75 and 150 mg/kg/day or propranolol (10 mg/kg/day). On days 15 and 16, they were injected subcutaneously with isoproterenol (85 mg/kg/day). Blood pressure and heart rate w… Show more

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Cited by 6 publications
(3 citation statements)
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“…The aorta rings were harvested and mounted as previously described by Nguelefack-Mbuyo et al [ 19 ]. Rats were euthanized via cervical dislocation, and the thoracic aorta was quickly and meticulously dissected out and put in physiological Krebs solution at 37 °C.…”
Section: Methodsmentioning
confidence: 99%
“…The aorta rings were harvested and mounted as previously described by Nguelefack-Mbuyo et al [ 19 ]. Rats were euthanized via cervical dislocation, and the thoracic aorta was quickly and meticulously dissected out and put in physiological Krebs solution at 37 °C.…”
Section: Methodsmentioning
confidence: 99%
“…Following blood collection, heart tissue was immediately excised and rinsed in ice‐cold normal saline before being homogenized in 0.1 mM phosphate buffer (pH 7.4) with a basic homogenizer. [ 21 ] The whole myocardium homogenate was centrifuged at 12,000 g for 10 min at 4°C and the supernatant was stored at −80°C for the estimation of various biochemical parameters and enzyme‐linked immunosorbent assay.…”
Section: Methodsmentioning
confidence: 99%
“…Isoproterenol (Iso)-induced AMI has become one of the most characteristic models commonly used to evaluate cardioprotective drugs. 6 Iso is a β-receptor agonist which can increase myocardial oxygen consumption by enhancing myocardial contraction and heart rate, causing cardiac overload, impairment of myocardial microcirculation, and myocardial infarction. The pathogenesis of Iso-induced AMI mice is related to oxidative stress and apoptosis.…”
Section: Introductionmentioning
confidence: 99%