Vasorelaxant effect of standardized extract of Cecropia glaziovii Snethl encapsulated in PLGA microparticles: In vitro activity, formulation development and release studies

Santos, Talitha Caldas dos; Battisti, Mariana Alves; Lobo, Kiuanne Lino; Caon, Thiago; Linder, A. Elizabeth; Sonaglio, Diva; Campos, Angela Machado de

doi:10.1016/j.msec.2018.06.046

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…The antihypertensive effect of C. glaziovii has demonstrated in rats with an aqueous extract, and the mechanism of action on animals was not due to ACE inhibition or nitric oxide (NO) synthesis but generated long-term hypotension in an l-NAME model of hypertension [22,23]. This antihypertensive effect could be explained by a vasorelaxant action promoted by a hydroethanolic extract obtained from the leaves of C. glaziovii, which was endothelium-dependent, confirming the need for endothelial factors to observe the phenomenon [24]. Extract from C. glaziovii has a bronchodilator effect, as demonstrated by Delarcina et al, which inhibits bronchospasm histamine-induced in guinea pigs after treatment with aqueous extract or semi-purified fractions [25].…”

Section: Daga Et Almentioning

confidence: 89%

A Review of the Anti-Inflammatory and Antimicrobial Activities of the Components of the Cecropia Genus

Daga

Ayala

Menolli

2020

Asian J Pharm Clin Res

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The genus Cecropia belongs to the Urticaceae family and has a wide diversity of species in several regions of South America. In folk medicine, they have many uses, such as hypoglycemic, antihypertensive, anti-inflammatory, and sedative. Species of the genus Cecropia, such as Cecropia pachystachya, Cecropia glaziovii, and Cecropia obtusifolia, have been the subject of several phytochemical studies, and the main isolated compounds were orientin, isoorientin, isovitexin, vitexin, as well as c-glycosylflavonoid compounds. These active compounds were characterized as responsible for the use of Cecropia plants in the treatment of inflammation and also as antimicrobial agents. This review aims to describe the main characteristics of the genus Cecropia, exploring the compounds responsible for the medicinal uses of these species and focusing on anti-inflammatory and antimicrobial uses.

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Section: Daga Et Almentioning

confidence: 89%

A Review of the Anti-Inflammatory and Antimicrobial Activities of the Components of the Cecropia Genus

Daga

Ayala

Menolli

2020

Asian J Pharm Clin Res

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“…PLGA-MH microspheres were prepared using a modified double emulsion (w1/o/w2) solvent extraction/evaporation technique (dos Santos et al, 2018). Briefly, 150 mg of MH were solubilized in 500 μL of distilled water (internal aqueous phase, w1), and added to 5 mL of dichloromethane containing 500 mg of PLGA (oil phase, o).…”

Section: Preparation Of Plga-mh Microspheresmentioning

confidence: 99%

“…Then, it was filled with approximately 200 mg of microspheres, suspended in 50 mL of phosphate buffer pH 6.8 (release medium), and maintained in a thermostatic water bath with magnetic stirring (DI-06, Dist, Brazil) at 37 °C and 150 rpm. At predetermined time intervals, 1 mL of the release medium was withdrawn and replaced with the same volume of fresh medium (dos Santos et al, 2018). The MH concentration in each aliquot was quantified in a UV-Vis spectrophotometer (UV-1800, Shimadzu, Japan) at 232 nm.…”

Section: In Vitro Mh Release From Plga Microspheresmentioning

confidence: 99%

Transport properties of hydrophilic compounds in PLGA microspheres

Burin

Santos

Battisti

et al. 2022

RSD

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Biodegradable polyesters, such as the poly(lactic-co-glycolic acid) (PLGA), have been extensively used as a polymer matrix for entrapping a variety of active compounds. In this study, the physicochemical phenomena that control the mass transport mechanism of hydrophilic compounds released from PLGA microspheres were identified. This study aims to produce and characterize PLGA microspheres loaded with metformin hydrochloride (MH) and perform a case study using the literature data of PLGA microspheres loaded with fluorescein isothiocyanate-dextran (FITC-dextran). The MH is a low molecular weight compound that was easily and rapidly transported by diffusion mechanism through the microsphere pores. The FITC-dextran, as a high molecular weight compound, depended on the mechanism of polymer erosion and mesopore formation, with 18 days of duration, before its release by diffusion mass transfer. Values of the effective diffusion coefficient of MH and FITC-dextran, both in PLGA, were 2.4 x 10-13 and 5.3 x 10-18 m2 s-1, respectively, with a difference of five orders of magnitude attributed to the molecular weight of these hydrophilic compounds and the main mass transport that governed their release. This study provides important insights into the mechanisms of mass transfer and their correlation with the physicochemical properties of both hydrophilic compounds and the PLGA matrix, contributing to the development of biodegradable controlled delivery systems for a variety of applications in chemical, biotechnological, and pharmaceutical industries.

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“…Other promising applications include the further study of Cglycosyl flavonoid enriched fraction of C. glaziovii-loaded nanospheres and standardized hydroethanolic C. glaziovii-loaded PLGA microparticles as drug delivery systems to treat labial herpes and hypertension [117][118][119]. In these investigations, the developed particle preparations were proposed to be capable of overcoming the bioavailability, permeability, and solubility issues associated with flavonoids [118,119]. Additionally, a magnetic emulsion nanoparticle of maghemite dispersed in an aqueous extract of C. obtusifolia leaves provided long-term biocompatibility and chemical stability to the extract [120].…”

Section: Future Perspectivesmentioning

confidence: 99%

Pharmacognostic Evaluation of Ten Species of Medicinal Importance of Cecropia: Current Knowledge and Therapeutic Perspectives

et al. 2021

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This work covers a systematic review of literature about the genus Cecropia from 1978 to 2020, emphasizing the analysis of 10 of the most relevant species and their associated biological activities. Cecropia is a neotropical genus, which comprises about 61 native species in the American continent where it is known to be part of the traditional medicine of numerous countries. Secondary metabolites described for this genus showed an elevated structural and functional diversity, where polyphenols have been the most abundant. Based on this diversity, Cecropia phytochemicals represent an important source of potential therapeutic agents yet to be exploited. This review also highlights the effectiveness of combining chemometrics and ultra-performance liquid chromatography-tandem mass spectrometry as a novel approach to successfully single out Cecropia species phytochemicals. While the medicinal use of Cecropia species is officially recognized in National Pharmacopoeias and Formularies of several Latin American countries, it is important to recognize that these phytomedicines are complex mixtures requiring a thorough understanding of their chemical composition and their correlation with biological activities to guarantee their quality, safety, and efficacy.

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Vasorelaxant effect of standardized extract of Cecropia glaziovii Snethl encapsulated in PLGA microparticles: In vitro activity, formulation development and release studies

Cited by 8 publications

References 28 publications

A Review of the Anti-Inflammatory and Antimicrobial Activities of the Components of the Cecropia Genus

A Review of the Anti-Inflammatory and Antimicrobial Activities of the Components of the Cecropia Genus

Transport properties of hydrophilic compounds in PLGA microspheres

Pharmacognostic Evaluation of Ten Species of Medicinal Importance of Cecropia: Current Knowledge and Therapeutic Perspectives

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