Vasorelaxation, endothelium, and wine

Fitzpatrick, David; Maggi, David A.; Bing, Bettye; Coffey, Ronald G.; Fries, D M

doi:10.1002/biof.5520060418

Cited by 7 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, it was reported that the flavonoids leucocianidol (10), delphinidin (24), epicatechin 3-O-galate (25), and proanthocyanidins (26) have endothelial NO-induced vasorelaxant activity. However, little information is available concerning the identity of the compounds responsible for endothelial NOinduced vasorelaxant activity, and we suspect that extracts of various plants or wines that have vasorelaxant effects contain other more potent components.…”

Section: Discussionmentioning

confidence: 99%

Endothelium-Dependent Vasorelaxation Induced by Black Currant Concentrate in Rat Thoracic Aorta

Nakamura¹,

Matsumoto²,

Todoki

2002

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

ABSTRACT-We investigated the effect of black currant (BC) concentrate on smooth muscle in rat thoracic aorta. BC concentrate dose-dependently relaxed the norepinephrine (0.1 mM)-precontracted aorta, and the response was abolished after endothelium removal. Both oxyhemoglobin (1 mM), a nitric oxide (NO) scavenger, and 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ, 0.5 mM), an inhibitor of guanylyl cyclase (GC), inhibited the relaxing effect of BC concentrate. N G -nitro-L-arginine methyl ester (L-NAME, 10 mM), a nitric oxide synthase (NOS) inhibitor, inhibited the relaxation, and the subsequent addition of L-arginine (1 mM), a NOS substrate, reversed the inhibitory effects of L-NAME. Neither indomethacin (10 mM), an inhibitor of cyclooxygenase, nor atropine (1 mM), an antagonist of muscarinic receptors, modified the effect of BC concentrate. Diphenhydramine (3 m M) and chlorpheniramine (2 mM), selective antagonists of H1-receptors, inhibited the relaxation, but cimetidine (0.3 mM), a selective antagonist of H2-receptors, did not affect the relaxation. These results indicate that, in the rat aorta, BC concentrate enhances synthesis of NO, which subsequently induces the endothelium-dependent vasorelaxation via the H1-receptors on the endothelium.

show abstract

Section: Discussionmentioning

confidence: 99%

Endothelium-Dependent Vasorelaxation Induced by Black Currant Concentrate in Rat Thoracic Aorta

Nakamura¹,

Matsumoto²,

Todoki

2002

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…47,48 The flavan-3-ols epicatechin and catechin are also present in cocoa, but the main cocoa polyphenols are procyanidins. 41,49 Whereas the flavanols or gallic acid were found to exhibit no or only modest vasodilatory or ni-tric oxide-stimulating effects in different experimental settings [50][51][52][53][54] and there are no data on vascular effects of thearubigins and theaflavins, the fraction of oligomeric procyanidins demonstrated a strong vasodilation. 52,53 Furthermore, in humans, bioavailability of phenolic compounds from cocoa has been reported not only for the monomeric flavanols but also for the procyanidin oligomers.…”

Section: Commentmentioning

confidence: 99%

Effect of Cocoa and Tea Intake on Blood Pressure

Taubert

Roesen²,

Schömig³

2007

Arch Intern Med

263

183

View full text Add to dashboard Cite

Background: Epidemiological evidence suggests blood pressure-lowering effects of cocoa and tea. We undertook a meta-analysis of randomized controlled trials to determine changes in systolic and diastolic blood pressure due to the intake of cocoa products or black and green tea.Methods: MEDLINE, EMBASE, SCOPUS, Science Citation Index, and the Cochrane Controlled Trials Register were searched from 1966 until October 2006 for studies in parallel group or crossover design involving 10 or more adults in whom blood pressure was assessed before and after receiving cocoa products or black or green tea for at least 7 days.Results: Five randomized controlled studies of cocoa administration involving a total of 173 subjects with a median duration of 2 weeks were included. After the cocoa

show abstract

“…produced EDR effects and increased NO production in rat aorta, whereas (+)catechin, a closely related compound, had no such effect (Andriambeloson et al, 1997). Epicatechin 3-O-gallate isolated from grape seeds was shown to have some EDR activity (Fitzpatrick et al, 1997), but other unidentified catechin-type compounds, including the proanthocyanidins, appeared to be considerably more active.…”

Section: Introductionmentioning

confidence: 97%

Isolation and Characterization of Endothelium-Dependent Vasorelaxing Compounds from Grape Seeds

Fitzpatrick

Fleming

Bing

et al. 2000

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

Previous work has shown that red wines, grape juices, and other grape products cause endothelium-dependent relaxation (EDR) of blood vessels in vitro by increasing nitric oxide production. In this paper we describe the isolation and characterization of some of the compounds responsible for EDR activity. Concord grape seeds were extracted with methanol and the compounds were separated by Toyopearl TSK HW-40S chromatography. Resulting fractions (primarily phenolic acids, catechins, and proanthocyanidins) were further separated semipreparatively by reversed-phase HPLC, and peaks were collected and bioassayed for EDR activity using the rat aorta preparation. EDR-active compounds were subsequently characterized by HPLC retention times and electrospray-ion-trap mass spectrometry. The compounds exhibiting the most EDR activity were proanthocyanidin trimers, tetramers, pentamers, and polymers and their gallates, as well as a dimer gallate (EC50 values in the range of 0.6-2.5 microg catechin equivalents/mL). These compounds should be useful for in vitro and in vivo studies, particularly as they relate to improvement of cardiovascular function.

show abstract

Vasorelaxation, endothelium, and wine

Cited by 7 publications

References 13 publications

Endothelium-Dependent Vasorelaxation Induced by Black Currant Concentrate in Rat Thoracic Aorta

Endothelium-Dependent Vasorelaxation Induced by Black Currant Concentrate in Rat Thoracic Aorta

Effect of Cocoa and Tea Intake on Blood Pressure

Isolation and Characterization of Endothelium-Dependent Vasorelaxing Compounds from Grape Seeds

Contact Info

Product

Resources

About