VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer

Abstract

Multi-drug resistance (MDR) presents a serious problem in cancer chemotherapy. In this study, Vitamin E (VE)-Albumin core-shell nanoparticles were developed for paclitaxel (PTX) delivery to improve the chemotherapy efficacy in an MDR breast cancer model. The PTX-loaded VE-Albumin core-shell nanoparticles (PTX-VE NPs) had small particle sizes (about 100 nm), high drug entrapment efficiency (95.7%) and loading capacity (12.5%), and showed sustained release profiles, in vitro. Docking studies indicated that the hydrophobic interaction and hydrogen bonds play a significant role in the formation of the PTX-VE NPs. The results of confocal laser scanning microscopy analysis demonstrated that the cell uptake of PTX was significantly increased by the PTX-VE NPs, compared with the NPs without VE (PTX NPs). The PTX-VE NPs also exhibited stronger cytotoxicity, compared with PTX NPs with an increased accumulation of PTX in the MCF-7/ADR cells. Importantly, the PTX-VE NPs showed a higher anti-cancer efficacy in MCF-7/ADR tumor xenograft model than the PTX NPs and the PTX solutions. Overall, the VE-Albumin core-shell nanoparticles could be a promising nanocarrier for PTX delivery to improve the chemotherapeutic efficacy of MDR cancer.

Emerging Mono‐Elemental Bismuth Nanostructures: Controlled Synthesis and Their Versatile Applications

“…Alloy and heterojunction nanomaterials have received tremendous interest in nanoscience and nanotechnology due to the synergistic effect. [174][175][176][177][178][179][180] The design of a large number of nanomaterials with heterojunctions in the interface between two different crystalline regions is indeed playing a vital role in the advanced materials for high-performance device applications. [181][182][183][184][185][186][187][188] Benefiting from the facilely controlled morphology and thickness-dependent bandgap, the synthetic approaches and versatile applications of Bi-based alloys and heterojunctions have quickly launched up in recent years.…”

<p>Cell membrane camouflaged nanoparticles: a new biomimetic platform for cancer photothermal therapy</p>

“…Moreover, safety concerns about non-biodegradable inorganic materials such as oxidative stress and lung inflammation, impaired efficiency of anti-tumor ability are asked by researchers. Answer to these questions, many approaches have been developed 14 – 16. Polyethylene glycol (PEG) modification of NPs has been made to enhance the longevity in blood circulation.…”

Integration of Molecular Docking and In Vitro Studies: A Powerful Approach for Drug Discovery in Breast Cancer

“…Paclitaxel (PTX), also known as Taxol, is used as a drug in clinical treatment against different cancers. However, as it causes different side effects, Tang et al [69] suggested vitamin E (VE)-albumin core-shell nanoparticles (NPs) to improve the efficacy of PTX in BC models. They also investigated the cytotoxicity with in vitro approaches on MCF-7 BC cell lines.…”

“…They also investigated the cytotoxicity with in vitro approaches on MCF-7 BC cell lines. Docking studies were performed to analyze the interaction between PTX or VE and BSA, and the results demonstrated a strong receptor-ligand interaction and PTX-VE NPs exhibited better cytotoxic effects than PTX NPs [69].…”