Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology

Abstract

The use of vegetable butters and oils shows promising results in the treatment of skin wounds, as they have an effective impact on the phases of the wound-healing process through their antimicrobial, anti-inflammatory, and antioxidative activities and by promoting cell proliferation, increasing collagen synthesis, stimulating dermal reconstruction, and repairing the skin's lipid barrier function.In this article, in vitro and in vivo studies of argan (Argania spinosa), avocado (Persea americana), black cumin (Nigella sativa), calophyllum (Calophyllum inophyllum), coconut (Cocos nucifera), cranberry (Vaccinium macrocarpon), grape (Vitis vinifera), green coffee (Coffea arabica), lentisk (Pistacia lentiscus), linseed (Linum usitatissimum), lucuma (Pouteria lucuma), mango (Mangifera indica), olive (Olea europaea), pomegranate (Punica granatum), pumpkin (Cucurbita pepo), rapeseed (Brassica napus), sea buckthorn (Hippophae rhamnoides), and sunflower (Helianthus annuus) oils were reviewed. In many cases, vegetable oils proved to be more effective than synthetic wound-healing compounds used as controls.The fatty-acid components of vegetable oils are assumed to play a major role in the wound-healing process, in particular polyunsaturated fatty acids such as linoleic acid.Evidence shows that oils with a higher linoleic to oleic acid ratio are more effective for lipid barrier repair. However, in depth studies are needed to gain knowledge about vegetable oils' effects on the skin and vice versa. KEYWORDSfatty acids, skinskin woundskin wound healingvegetable buttersvegetable oils

Keratinocytes Migration Promotion, Proliferation Induction, and Free Radical Injury Prevention by 3-Hydroxytirosol

“…With regard to dermatological diseases, recent studies have shown that the daily consumption of olive oil through the Mediterranean dietary pattern, is associated with a lower incidence of skin tumors, but also with a better healing of pressure ulcers, thanks to a reduction in oxidative damage, a better dermal reconstruction, and a reduction in collagen deposition time [25,26]. As already seen from a daily intake of olive oil, several scientific studies have reported that even olive oil creams applied topically have been proven to be effective for the treatment of patients with chronic wounds, having the ability to reduce the size, depth, and wound edges, along with associated pain, thanks to the antibacterial and anti-inflammatory effects of polyphenols [27,30]. In addition, it has been shown that HT may be a potential alternative therapeutic agent for the treatment of several autoimmune and inflammatory disorders.…”

“…Better wound healing has also been associated with the antibacterial effects of polyphenols present in the oil [28], configuring it as also useful in the treatment of burns [28,29]. Some studies suggest that the positive effects of olive oil in promoting wound healing are due to the modulation of early stages of the reparative process such as inflammation and stimulation of dermal reconstruction [30].…”

Home remedies in different pediatric dermatoses: An observational study

“…[2][3][4] Coconut oil and mustard oil have been found to have an inhibitory effect on dermatophytes in vitro, but their application has been found to be associated with increased risk of fungal infections which may be attributed to increased moisture retention. 5,6 Olive oil has also been found effective in reducing the TEWL and improving the skin barrier and reducing the severity of atopic dermatitis. 7,8 Aloe vera is also known for its antiinflammatory properties as it inhibits the cyclooxygenase pathway and reduces prostaglandin E2 production from arachidonic acid.…”

“…Coconut oil is an effective emollient and has been shown to reduce the transepidermal water loss and improve the skin barrier function and reduce the atopic dermatitis severity 2‐4 . Coconut oil and mustard oil have been found to have an inhibitory effect on dermatophytes in vitro, but their application has been found to be associated with increased risk of fungal infections which may be attributed to increased moisture retention 5,6 . Olive oil has also been found effective in reducing the TEWL and improving the skin barrier and reducing the severity of atopic dermatitis 7,8 .…”

Avaliação da atividade antibacteriana do óleo de girassol: Respaldo para a enfermagem

“…Estes AGE contribuem com o processo de reparação tecidual 4 , pois têm um impacto efetivo nas fases do processo de cicatrização de feridas por meio de atividades anti-inflamatórias e antioxidantes. Também colaboram na promoção da proliferação celular, a qual aumenta a síntese de colágeno, estimula uma nova vascularização e causa um aumento considerável da migração de leucócitos e macrófagos, proporcionando a regulação dos processos que precedem a mitose de células fibroblásticas e reparação da função de barreira lipídica da pele (Poljšak et al, 2020;Saturno, et al, 2017). Do mesmo modo que se conheça os efeitos benéficos do OG para a cicatrização da ferida, a presença de microrganismos em feridas cutâneas é um problema reconhecido como uma importante causa de cicatrização prolongada, logo, a eliminação de infecções é imprescindível para a recuperação tecidual (Kotnis-Gąs, et al, 2018).…”