Vegetable Oil-Based Ricinelaidic Acid Organogels; Phase Behavior, Microstructure, and Rheology

Wright, Amanda J.; Marangoni, Alejandro G.

doi:10.1016/b978-0-12-814270-7.00003-4

Cited by 4 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All HOA in SO organogels were gelled at 25 0 C and showed no flow after vial inversion, as shown in Figure 1. The gelation concentrations were similar to another study using HOA in canola oil, diacylglycerol oil and unrefined sesame oil (14) . Furthermore, the addition of CN did not disturb the organogel formation.…”

Section: Preparation Of Organogelsupporting

confidence: 85%

Study the Effect of 12-Hydroxyoctadecanoic Acid Concentration on Preparation and Characterization of Floating Organogels using Cinnarizin as Modeling Drug

Mohamed

Kadoori

Hameed³

2022

IJPS

View full text Add to dashboard Cite

This work targeted studying organogel as a potential floating system. Organgel has an excellent viscoelastic properties, floating system posses a depot property. Different formulations of 12-hydroxyoctadecanoic acid (HOA) in sesame oil were gelled and selecting F1, F3 and F5 HOA organogels for various examinations: tabletop rheology, optical microscopy, and oscillatory rheology studies. Also, the floating properties studies were conducted at in vitro and in-vivo levels. Lastly, the in-vitro release study using cinnarizine (CN) was to investigate the organogel depot property. Based on the results, the selected concentrations of HOA in sesame oil organogels showed temperature transitions from gel to sol higher than body temperature. These organogels scaffolds inner structures were a star-like shape. The formulation F5 HOA/SO organogels were developing higher storage modulus values, which resulted from the amplitude sweep study. Indeed, all the selected organogels were frequency sweep independent. The organogel’s in vitro floating properties were found positively proven our work’s aim and were buoyant for 24 hours as F5 HOA organogels remained for 12 hours in the rat’s stomach. The depot property showed the slow release of CN from F5 HOA/SO organogel and not more than 65% w/w of CN released after 24 hours.

show abstract

Section: Preparation Of Organogelsupporting

confidence: 85%

Study the Effect of 12-Hydroxyoctadecanoic Acid Concentration on Preparation and Characterization of Floating Organogels using Cinnarizin as Modeling Drug

Mohamed

Kadoori

Hameed³

2022

IJPS

View full text Add to dashboard Cite

show abstract

“…Not only are these compounds approved for use in food applications, but they have been proven to actively have an impact in lowering blood LDL cholesterol and reducing the risk of coronary heart disease, according to the European Food Safety Authority (EFSA) [ 47 ]. Other LMOGs such as 12-hydroxystearic acid and ricinoleic acid are examples of oleogelators that can be incorporated either as the only gelator or in mixed systems [ 44 , 48 , 49 ].…”

Section: Oleogel Preparation For Food Applicationsmentioning

confidence: 99%

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

Pinto

Martins

Pastrana

et al. 2021

Gels

View full text Add to dashboard Cite

Oleogels are semi-solid materials containing a large fraction of liquid oil entrapped in a network of structuring molecules. In the food industry, these formulations can be used to mimic fats and to deliver bioactive compounds. In the last decade, there has been increasing interest in these structures, not only from a scientific point of view, i.e., studying new molecules, methodologies for gelification, and new structures, but also from a technological point of view, with researchers and companies exploring these structures as a way to overcome certain challenges and/or create new and innovative products. One of the exciting applications of oleogels is the delivery of functional molecules, where the incorporation of oil-soluble functional compounds can be explored not only at the macroscale but also at micro- and nanoscales, resulting in different release behaviors and also different applications. This review presents and discusses the most recent works on the development, production, characterization, and applications of oleogels and other oleogel-based systems to deliver functional molecules in foods.

show abstract

“…Sorbitan monostearate (SMS) is a hydrophobic, non-ionic surfactant used as an emulsifier and forms an organogel of organic solvents (e.g., hexadecane, isopropyl myristate, and a range of vegetable oils, such as sesame oil, groundnut oil, olive oil, soybean oil, and sunflower oil) [26,27]. This compound has been evaluated as a potential drug-delivery vehicle.…”

Section: Introductionmentioning

confidence: 99%

A Poly (Caprolactone)-Cellulose Nanocomposite Hydrogel for Transdermal Delivery of Hydrocortisone in Treating Psoriasis Vulgaris

et al. 2022

View full text Add to dashboard Cite

Psoriasis vulgaris (PV) is a common chronic disease, affecting much of the population. Hydrocortisone (HCT) is currently utilized as a PV treatment; however, it is associated with undesirable side effects. The aim of this research was to create a thermo-responsive nano-hydrogel delivery system. HCT-loaded sorbitan monostearate (SMS)-polycaprolactone (PCL) nanoparticles, encapsulated with thermo-responsive hydrogel carboxymethyl cellulose (CMC), were synthesized by applying the interfacial polymer-deposition method following solvent displacement. The nanoparticles’ properties were evaluated employing Differential Scanning Colorimetry, Thermogravimetric Analysis, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Zeta sizer, Ultraviolet/Visual spectroscopy, and cytotoxicity testing. The nanoparticle sizes were 110.5 nm, with polydispersity index of 0.15 and zeta potential of −58.7 mV. A drug-entrapment efficacy of 76% was attained by the HCT-loaded SMS-PCL nanoparticles and in vitro drug-release profiles showed continuous drug release over a period of 24 hrs. Keratinocyte skin cells were treated with HCT-loaded SMS-PCL nanoparticles encapsulated with CMC; the results indicated that the synthesized drug-delivery system was less toxic to the keratinocyte cells compared to HCT. The combined trials and results from the formulation of HCT-loaded SMS-PCL nanoparticles encapsulated with CMC showed evidence that this hydrogel can be utilized as a potentially invaluable formulation for transdermal drug delivery of HCT, with improved efficacy and patient conformity.

show abstract

Vegetable Oil-Based Ricinelaidic Acid Organogels; Phase Behavior, Microstructure, and Rheology

Cited by 4 publications

References 24 publications

Study the Effect of 12-Hydroxyoctadecanoic Acid Concentration on Preparation and Characterization of Floating Organogels using Cinnarizin as Modeling Drug

Study the Effect of 12-Hydroxyoctadecanoic Acid Concentration on Preparation and Characterization of Floating Organogels using Cinnarizin as Modeling Drug

Oleogel-Based Systems for the Delivery of Bioactive Compounds in Foods

A Poly (Caprolactone)-Cellulose Nanocomposite Hydrogel for Transdermal Delivery of Hydrocortisone in Treating Psoriasis Vulgaris

Contact Info

Product

Resources

About