VEGF and M-CSF levels in periodontal tissue during tooth movement

Kaku, Masato; Motokawa, Masaharu; Tohma, Yuiko; Tsuka, Natsumi; Koseki, Hiroyuki; Sunagawa, Hiroko; Hernandes, R.A.M.; Ohtani, Junji; Fujita, Tadashi; Kawata, Toshitsugu; Tanne, Kazuo

doi:10.2220/biomedres.29.181

Cited by 44 publications

(30 citation statements)

References 35 publications

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“…An increase in both VEGF and GM-CSF concentrations in the GCF during canine retraction has been reported. 34 These factors may induce bone remodeling via osteoclastic bone resorption.…”

Section: Granulocyte Macrophage Colony Stimulating Factormentioning

confidence: 99%

Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review

Alhadlaq¹

2015

The Journal of Contemporary Dental Practice

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Background The analysis of gingival crevicular fluid (GCF) may be an acceptable way to examine the ongoing biochemical processes associated with bone turnover during orthodontic tooth movement. If it is possible to biologically monitor and predict the outcome of orthodontic forces, then the management of appliances could be based on individual tissue responses, and the effectiveness of the treatment could be improved. Methodology A literature search was carried out in major databases, such as medline, EMBASE, cochrane library, web of science, google scholar and scopus for relevant studies. Publications in English between 2000 and 2014 which estimated GCF markers as indicators of orthodontic tooth movement were included. Results The list of biomarkers available to date was compiled and presented in table format. Each biomarker is discussed separately based on the available evidence. Conclusion Several sensitive GCF markers are available to detect the biomechanical changes occurring during orthodontic tooth movement. Further focused research might help to analyze the sensitivity and reliability of these indicators, which in turn can lead to the development of chairside tests to assess the outcome of orthodontic therapy. How to cite this article Alhadlaq AM. Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review. J Contemp Dent Pract 2015;16(7):578-587.

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“…An increase in both VEGF and GM-CSF concentrations in the GCF during canine retraction has been reported. 34 These factors may induce bone remodeling via osteoclastic bone resorption.…”

Section: Granulocyte Macrophage Colony Stimulating Factormentioning

confidence: 99%

Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review

Alhadlaq¹

2015

The Journal of Contemporary Dental Practice

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“…IL-4 [50, 51], IL-12 [55, 56], IL-18 [59, 60], and IFN- γ [61] inhibit TNF- α -induced osteoclast formation in vitro and in vivo . It has been reported that the cytokines IL-1 β [62], TNF- α [38, 43, 44], IL-6 [63–65], IL-8 [64, 65], RANKL [66], M-CSF [67], TGF- β [68], IL-2 [65], and IFN- γ [69] were locally increased during orthodontic tooth movement. These cytokines may affect osteoclast formation during orthodontic tooth movement.…”

Section: Effect Of Cytokines On Mechanical Loading-induced Osteoclmentioning

confidence: 99%

Effect of Cytokines on Osteoclast Formation and Bone Resorption during Mechanical Force Loading of the Periodontal Membrane

Kitaura

Kimura

Ishida

et al. 2014

The Scientific World Journal

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Mechanical force loading exerts important effects on the skeleton by controlling bone mass and strength. Several in vivo experimental models evaluating the effects of mechanical loading on bone metabolism have been reported. Orthodontic tooth movement is a useful model for understanding the mechanism of bone remodeling induced by mechanical loading. In a mouse model of orthodontic tooth movement, TNF-α was expressed and osteoclasts appeared on the compressed side of the periodontal ligament. In TNF-receptor-deficient mice, there was less tooth movement and osteoclast numbers were lower than in wild-type mice. These results suggest that osteoclast formation and bone resorption caused by loading forces on the periodontal ligament depend on TNF-α. Several cytokines are expressed in the periodontal ligament during orthodontic tooth movement. Studies have found that inflammatory cytokines such as IL-12 and IFN-γ strongly inhibit osteoclast formation and tooth movement. Blocking macrophage colony-stimulating factor by using anti-c-Fms antibody also inhibited osteoclast formation and tooth movement. In this review we describe and discuss the effect of cytokines in the periodontal ligament on osteoclast formation and bone resorption during mechanical force loading.

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“…Therefore, application of static tensional force increases genes related to angiogenesis in PDL cells. For orthodontic tooth movement, VEGF mRNA expression was found in PDL cells and VEGF concentration increased in gingival crevicular fluid (16). The expression of VEGF, highly sensitive to the mechanical stress (17), is detected in osteoblasts on the tension side (18) while induction of VEGF-A by mechanical stress can increase new bone formation (19).…”

Section: Genes Related To Collagen Synthesis and The Angiogenesismentioning

confidence: 99%

Static tensional forces increase osteogenic gene expression in three-dimensional periodontal ligament cell culture

Ku¹,

Chang²,

Chae³

et al. 2009

BMB Reports

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Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to identify genes in human periodontal ligament (PDL) cells that undergo significant changes in expression in response to static tensional forces (2 or 12 hours). The genes found were alkaline phospatase (ALP), matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), and several collagen genes. Furthermore, an ELISA evaluating the expression of VEGF, type IV collagen and MMP-2 found levels significantly increased after 24 and 72 hours (P ＜ 0.05). ALP activity was also increased after 24 hours (P ＜ 0.05). Collectively, we found the genes up-regulated in our study by the static tensional force are related to osteogenic processes such as matrix synthesis and angiogenesis. [BMB reports 2009; 42(7): 427-432]

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VEGF and M-CSF levels in periodontal tissue during tooth movement

Cited by 44 publications

References 35 publications

Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review

Biomarkers of Orthodontic Tooth Movement in Gingival Crevicular Fluid: A Systematic Review

Effect of Cytokines on Osteoclast Formation and Bone Resorption during Mechanical Force Loading of the Periodontal Membrane

Static tensional forces increase osteogenic gene expression in three-dimensional periodontal ligament cell culture

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