VEGF plasma levels in nonruptured intracranial aneurysms

Sandalcioglu, I. Erol; Wende, Doreen; Eggert, Angelika; Regel, Jens P.; Stolke, D.; Wiedemayer, H.

doi:10.1007/s10143-005-0411-8

Cited by 21 publications

(22 citation statements)

References 21 publications

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“…12 A recent study reported a significant increase in circulating VEGF levels in AVM patients compared to healthy controls. 40 Increased expression of circulating VEGF has also been associated with other cerebrovascular disorders including intracranial aneurysms, 41 dural arteriovenous fistulas, 21 and vasospasm after subarachnoid hemorrhage. 5 VEGF expression is regulated by numerous factors, most significantly hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Vascular Endothelial Growth Factor After Treatment for Cerebral Arteriovenous Malformations

Kim

Hahn

Kellner

et al. 2008

Stroke

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Background and Purpose— The role of abnormal angiogenesis in the formation and progression of cerebral arteriovenous malformations (AVMs) is unclear. Previous studies have demonstrated increased local expression of vascular endothelial growth factor (VEGF) in AVM tissue and increased circulating levels of VEGF in AVM patients. We sought to further investigate the role of VEGF in AVM pathophysiology by examining changes in plasma VEGF levels in patients undergoing treatment for AVMs. Methods— Three serial blood samples were obtained from 13 AVM patients undergoing treatment: (1) before any treatment, (2) 24 hours postresection, and (3) 30 days postresection. Plasma VEGF concentrations were measured via commercially available enzyme-linked immunosorbent assay (ELISA). For controls, blood samples were obtained from 29 lumbar laminectomy patients. Results— The mean plasma VEGF level in AVM patients at baseline was 36.08±13.02 pg/mL, significantly lower than that of the control group (80.52±14.02 pg/mL, P =0.028). Twenty-four hours postresection, plasma VEGF levels dropped to 20.09±4.54 pg/mL, then increased to 66.81±26.45 pg/mL 30 days later ( P =0.048). The mean plasma VEGF concentration 30 days after resection was no longer significantly different from the control group ( P =0.33). Conclusions— Plasma VEGF levels in 13 AVM patients were unexpectedly lower than controls, dropped early after AVM resection, then significantly increased 30 days later. These results support the key role of abnormal angiogenesis in AVM pathophysiology and suggest that a disruption in systemic VEGF expression may contribute to the natural history of these lesions.

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Section: Discussionmentioning

confidence: 99%

Plasma Levels of Vascular Endothelial Growth Factor After Treatment for Cerebral Arteriovenous Malformations

Kim

Hahn

Kellner

et al. 2008

Stroke

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“…Aneurysmal degeneration of intracranial arteries is a complex biological response reflecting the interplay of numerous inherited and acquired factors. 26) VEGF was expressed on the walls of all cerebral aneurysms analyzed. 28) In contrast, no VEGF expression was found on normal vessels.…”

Section: Discussionmentioning

confidence: 92%

De Novo Aneurysm in the Feeding Artery of a Recurrent Malignant Glioma -Case Report-

Sasagawa

Akai

Itou

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 52-year-old man underwent resection of an oligodendroglioma in the left frontal lobe, followed by chemoradiation therapy in 1989. He presented with a de novo aneurysm arising from the feeding artery of a recurrent malignant glioma in 2009. Serial follow-up magnetic resonance imaging showed no tumor progression until 19 years after the initial diagnosis. Angiography revealed an intratumoral aneurysm of the dilated feeding artery. The recurrent tumor was resected together with the aneurysm. Histological examination revealed that the tumor was an anaplastic oligodendroglioma, and the aneurysm was encased in the tumor. Clinicians should carefully look for tumor recurrence and aneurysm formation during follow up of patients treated for malignant glioma.

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“…Its plasma level is also elevated (eg, in patients with intracranial aneurysms). 12 These aneurysms have a significantly higher detection rate in patients with polycystic kidney diseases, which in turn are associated with Caroli disease. Interestingly, cholangiocytes derived from livers affected with Caroli disease have been shown to overexpress VEGF and its receptors.…”

Section: Figurementioning

confidence: 99%

Caroli Disease Associated With Vein of Galen Malformation in a Male Child

et al. 2014

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We report the first case of a male child with both Caroli disease and vein of Galen malformation. The neonate presented to our department with congestive heart failure as a result of the intracranial arteriovenous high-flow shunt. Over time, several endovascular embolizations led to a complete angiographic occlusion of the shunt. Additionally, the diagnosis of Caroli disease was made at the age of 2 months. He developed choledocholithiasis necessitating endoscopic sphincterotomy and stone extraction. As a prolonged medical treatment he received ursodeoxycholic acid and antibiotics. A coincidence of Caroli disease and vein of Galen malformation has not yet been described. Both diseases are very rare, leading to the question of whether there is a link in the pathogenesis. Based on the few previously described underlying mechanisms, we develop hypotheses about the relationship between both rare diseases. We consider overexpression of vascular endothelial growth factor and its receptors as a possible common molecular mechanism in their pathogenesis. We also highlight the critical role of increased expression of the Notch ligand Jagged 1 both in the development of cerebral arteriovenous malformations in general and in the formation of dilated intrahepatic bile ducts (eg, in Caroli disease).

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VEGF plasma levels in nonruptured intracranial aneurysms

Cited by 21 publications

References 21 publications

Plasma Levels of Vascular Endothelial Growth Factor After Treatment for Cerebral Arteriovenous Malformations

Plasma Levels of Vascular Endothelial Growth Factor After Treatment for Cerebral Arteriovenous Malformations

De Novo Aneurysm in the Feeding Artery of a Recurrent Malignant Glioma -Case Report-

Caroli Disease Associated With Vein of Galen Malformation in a Male Child

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