Vein Wall and Circulating P-selectin Promote Venous Thrombogenesis During Aging in a Rodent Model

Myers, Daniel D.; Culmer, Dorian Laird; Díaz, José; Hawley, Angela E.; Jackson, Tatum; Shuster, Katherine A; Sigler, Robert E.; Wakefield, T. W.

doi:10.1016/j.jvsv.2012.10.047

Cited by 2 publications

(2 citation statements)

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“…Ceramide induces the release of Weibel-Palade bodies from endothelial cells, 29,30 and promotes E-selectin dependent leucocyte adhesion onto endothelial cells. 31 Selectins have been shown to promote inflammation and venous thrombosis, 32,33 while inhibition of P-selectin may have a therapeutic role. 34 Ceramide contributes to oxidative stress by increasing the generation of reactive oxygen species and reducing nitric oxide availability.…”

Section: Discussionmentioning

confidence: 99%

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model

Sung

Spagou

Kafeza

et al. 2018

European Journal of Vascular and Endovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model

Sung

Spagou

Kafeza

et al. 2018

European Journal of Vascular and Endovascular Surgery

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“…According to studies, ceramides stimulate both the release of Weibel-Palade bodies from endothelial cells and E-selectin dependent leucocyte adhesion onto endothelial cells [ 67 , 68 ]. Selectins were demonstrated to stimulate inflammation and venous thrombosis [ 69 , 70 ]. The results of other studies indicate the involvement of ceramides and their products in coagulation.…”

Section: Deep Venous Thrombosis and Pulmonary Embolismmentioning

confidence: 99%

Metabolomic Profile in Venous Thromboembolism (VTE)

et al. 2021

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Venous thromboembolism (VTE) is a condition comprising deep venous thrombosis (DVT) and pulmonary embolism (PE). The prevalence of this disease is constantly increasing and it is also a chief reason for morbidity. Therefore, the primary prevention of VTE remains a highly important public health issue. At present, its diagnosis generally relies on subjective clinical examination and ultrasound imaging. D-dimer is also used as a biomarker, but it is considered to be poorly specific and only moderately sensitive. There are also no reliable methods that could accurately guide the type of treatment and potentially identify patients who may benefit from more aggressive therapies without the risk of bleeding. The application of metabolomics profiling in the area of vascular diseases may become a turning point in early diagnosis and patient management. Among the most described metabolites possibly related to VTE are carnitine species, glucose, phenylalanine, 3-hydroxybutarate, lactic acid, tryptophan and some monounsaturated and polyunsaturated fatty acids. The cell response to acute PE was suggested to involve the uncoupling between glycolysis and oxidative phosphorylation. Despite technological advancement in the identification of metabolites and their alteration in thrombosis, we still do not understand the mechanisms and pathways responsible for the occurrence of observed alterations.

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Vein Wall and Circulating P-selectin Promote Venous Thrombogenesis During Aging in a Rodent Model

Cited by 2 publications

References 1 publication

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model

Deep Vein Thrombosis Exhibits Characteristic Serum and Vein Wall Metabolic Phenotypes in the Inferior Vena Cava Ligation Mouse Model

Metabolomic Profile in Venous Thromboembolism (VTE)

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