Venodilatory Effect of Vascular Endothelial Growth Factor on Rat Gingiva

Abstract

There is no remarkable VEGF production under physiologic circumstances in rat gingiva, but VEGF is able to increase gingival blood flow through the activation of VEGF2 receptors. Furthermore, NO release may contribute to VEGF's vasodilatory effect.

Vascular Endothelial Growth Factor Modulates the Function of the Retinal Pigment Epithelium In Vivo

“…23 In the current study, PlGF (a specific VEGF-R1 agonist) had no effect on rate of resorption, and ZM323881 (a selective VEGF-R2 antagonist known to inhibit VEGF-R2 in human, 23 porcine, 23 rat, 45 and frog 46 tissues) reversed the VEGF-induced decline in subretinal fluid reabsorption. Taken together, these results supported the idea that responses to VEGF in the rabbit RPE are also mediated by the VEGF-R2 receptor subtype.…”

Identification of autonomic neuronal chains innervating gingiva and lip

“…Physiological data indicate that the blood supply of the gingiva and lip is regulated by both autonomic nervous system and local factors (Izumi et al, 1990;Izumi and Karita, 1991;Gyurkovics et al, 2009). The stimulation of the sympathetic nerves induced arterial constriction decreasing the blood flow (Izumi et al, 1990), the parasympathetic stimulation induced arterial dilation increasing the blood flow in the lower gingiva measured by a laser Doppler flowmeter.…”

“…It was also suggested that the parasympathetic fibers may reach the lower gingiva not only along the trigeminal, but also along the facial and glossopharyngeal nerves (Izumi and Karita, 1991). It was also shown that local factors such as nitric oxide and endothelial growth factor (Gyurkovics et al, 2009) or CGRP released at sensory nerve endings (Györfi et al, 1992;Helyes et al, 1997) may induce vasodilation in the gingiva. Although, the occurrence of parasympathetic fibers was demonstrated (Kuchiiwa and Kuchiiwa, 1996) but not confirmed in the gingiva, their presence is still a matter of debate.…”

Expression of Vascular Endothelial Growth Factor Has a Regulatory Role in Gingival Venules in Experimental Diabetes

“…Although there is no remarkable endogenous gingival VEGF production under normal circumstances, exogenous VEGF through VEGFR2 interaction is able to dilate the venules, thus decreasing the gingival vascular resistance. Moreover, the endothelium‐derived NO may be involved in the vasodilatory mechanism of VEGF 17 . The results of the other investigation suggest that VEGF has an important role in the vasodilation of the gingival venules in gingivitis as well 18 …”

“…In previous studies, the effects of a specific VEGFR2 antagonist in normal and experimental gingivitis were investigated 17–19 . The results demonstrated that functionally active VEGFR2s are located in the venules of the rat gingiva.…”