Venous Thromboembolic Disease and Abo Blood Type. A Cooperative Study

Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database

“…Inclusion of these factors in the stepwise regressions still showed multiple birth as an independent risk factor. Antenatal and postnatal venous thromboembolism incidence was increased in women with blood group A as compared with blood group O, which is consistent with previous ®ndings 15 suggesting some genetic in¯uence. There are con¯icting reports on the in¯uence of ethnic group on predisposition to venous thromboembolism.…”

Inherited Thrombophilia: Past, Present, and Future Research

“…Following this observation, a cooperative study was performed among women from the USA, UK, and Sweden that developed venous thrombosis while taking oral contraceptives, during pregnancy or the puerperium, or at other times. This study confirmed that there was a deficit of patients with blood group O, and the difference was larger when venous thromboembolism was associated with either oral contraceptive use or pregnancy (Jick et al, 1969). Blood group O is associated with lower levels of von Willebrand Factor (VWF) and Factor VIII.…”

“…In 1969, another heritable trait was found to be associated with thrombosis risk: non-O blood group. Blood group O is less often seen in thrombosis patients than one of the other blood groups (Jick et al, 1969). Protein C and protein S deficiencies were identified as genetic risk factors in thrombosis patients following the unraveling of the protein C anticoagulant system in the late 1970s and 1980s (Griffin et al, 1981;Schwarz et al, 1984).…”

Is there any relationship between ABO/Rh blood group and patients with pre-eclampsia?

“…This finding was supported by Pike and Dickins who reported a significant excess of group O in pre-eclamptic women [13] which was not found by Clark et al, [14]. Also, ABO blood group has been associated with several thrombotic disease states; for instance, blood group non-O increased risk for venous thrombosis [15,16] and ABO locus O¹ allele reduced risk for myocardial infarction [17]. Two systematic reviews and meta-analysis of studies analysing ABO blood group system in patients with pre-eclampsia was performed in 2008 and 2013.…”