Venous thromboembolism during pregnancy and the post‐partum period: Incidence and risk factors in a large Victorian health service

Sharma, Sanjay; Monga, Deepika

doi:10.1111/j.1479-828x.2007.00799.x

Cited by 38 publications

(35 citation statements)

References 18 publications

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“…The reason for its increased trend in the Chinese population remains unclear. The incidences of VTE and fatal pulmonary embolism (PE) during pregnancy among Chinese women were recently reported to be 160 and 1.4 per 100,000 pregnancies, respectively [5,6,7], similar to those reported in the Caucasian population [8,9,10]. Advanced maternal age, maternal obesity and cesarean delivery were risk factors for VTE during pregnancy in Chinese [5], but the rate of thrombophilia in Chinese women with VTE during pregnancy has not been studied.…”

Section: Introductionmentioning

confidence: 60%

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

Tam

Ng²,

Yiu

et al. 2012

Gynecol Obstet Invest

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Aims: To assess the prevalence of thrombophilia among Chinese women with venous thromboembolism (VTE) developed during pregnancy. Methods: Based on information from a tertiary teaching unit, all recorded cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) during pregnancy diagnosed between 1997 and 2005, were assessed for prevalence of thrombophilia. Fifty-five healthy women, who had at least one normal pregnancy but without any previous history of VTE, were recruited as controls. Results: A total of 44 subjects completed thrombophilia screening, of whom 5 (11%) were confirmed to have thrombophilia [protein C (PC) deficiency (2), protein S (PS) deficiency (1), combined PC & PS deficiency (1) and antithrombin III deficiency (1)]. Homozygous 5,10-methylenetetrahydrofolate reductase (C677T) gene mutation was found in 6 (14%) subjects but not in the controls. There was no antiphospholipid syndrome, activated PC resistance, factor V Leiden or prothrombin gene mutations. Conclusion: In the Chinese population, PS and PC deficiencies are common thrombophilia for VTE during pregnancy and thrombophilia screening should be recommended in all pregnant women who suffer from VTE.

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Section: Introductionmentioning

confidence: 60%

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

Tam

Ng²,

Yiu

et al. 2012

Gynecol Obstet Invest

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“…This is something we were not able to account of in our meta-analysis for postpartum VTE. Most of the previous literature on this subject has relied on secondary care data which will inevitably miss many non-fatal VTE events diagnosed and managed exclusively in primary care, particularly during the postpartum period [1], [19], [26], [27].…”

Section: Discussionmentioning

confidence: 99%

The Incidence of First Venous Thromboembolism in and around Pregnancy Using Linked Primary and Secondary Care Data: A Population Based Cohort Study from England and Comparative Meta-Analysis

et al. 2013

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BackgroundRecent linkage between primary and secondary care data has provided valuable information for studying heath outcomes that may initially present in different health care settings. The aim of this study was therefore, twofold: to use linked primary and secondary care data to determine an optimum definition for estimating the incidence of first VTE in and around pregnancy; and secondly to conduct a systematic literature review of studies on perinatal VTE incidence with the purpose of comparing our estimates.MethodsWe used primary care data from the Clinical Practice Research Datalink (CPRD), which incorporates linkages to secondary care contained within Hospital Episode Statistics (HES) between 1997 and 2010 to estimate the incidence rate of VTE in the antepartum and postpartum period. We systematically searched the literature on the incidence of VTE during antepartum and postpartum periods and performed a meta-analysis to provide comparison.FindingsUsing combined CPRD and HES data and a restrictive VTE definition, the absolute rate during the antepartum period and first six weeks postpartum (early postpartum) were 99 (95%CI 85–116) and 468 (95%CI 391–561) per 100,000 person-years respectively. These were comparable to the pooled estimates from our meta-analysis (using studies after 2005) during the antepartum period (118/100,000 person-years) and early postpartum (424/100,000 person-years). When we used only secondary care data to identify VTE events, incidence was lower during the early postpartum period (308/100,000 person-years), whereas relying only on primary care data lead to lower incidence during the time around delivery, but higher rates during the postpartum period (558/100,000 person-years).ConclusionUsing combined CPRD and HES data gives estimates of the risk of VTE in and around pregnancy that are comparable to the existing literature. It also provides more accurate estimation of the date of VTE diagnosis which will allow risk stratification during specific pregnancy and postpartum periods.

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“…The level B studies evaluated the incidence of VTE in various subpopulations, such as during pregnancy or the postpartum period, [43][44][45][46][47][48][49][50][51][52][53][54] men or women of selected age categories, [55][56][57][58][59][60][61][62][63][64] subgroups with or without selected risk factors or comorbidities, [65][66][67][68][69][70] or special categories of thrombosis.…”

Section: Incidence Of Vtementioning

confidence: 99%

Thrombosis

Raskob

Angchaisuksiri

Blanco

et al. 2014

ATVB

784

109

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Background— Thrombosis is the common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Disease Study 2010 (GBD 2010) documented that ischemic heart disease and stroke collectively caused 1 in 4 deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. Objective— To review the literature on the global burden of disease caused by VTE. Approach and Results— We performed a systematic review of the literature on the global disease burden because of VTE in low-, middle-, and high-income countries. Studies from Western Europe, North America, Australia, and Southern Latin America (Argentina) yielded consistent results with annual incidences ranging from 0.75 to 2.69 per 1000 individuals in the population. The incidence increased to between 2 and 7 per 1000 among those aged ≥70 years. Although the incidence is lower in individuals of Chinese and Korean ethnicity, their disease burden is not low because of population aging. VTE associated with hospitalization was the leading cause of disability-adjusted life-years lost in low- and middle-income countries, and second in high-income countries, responsible for more disability-adjusted life-years lost than nosocomial pneumonia, catheter-related blood stream infections, and adverse drug events. Conclusions— VTE causes a major burden of disease across low-, middle-, and high-income countries. More detailed data on the global burden of VTE should be obtained to inform policy and resource allocation in health systems and to evaluate whether improved use of preventive measures will reduce the burden.

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Venous thromboembolism during pregnancy and the post‐partum period: Incidence and risk factors in a large Victorian health service

Cited by 38 publications

References 18 publications

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

The Incidence of First Venous Thromboembolism in and around Pregnancy Using Linked Primary and Secondary Care Data: A Population Based Cohort Study from England and Comparative Meta-Analysis

Thrombosis

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