Ventilation-Perfusion Scanning in Carcinoma of the Bronchus

Secker-Walker, Roger H.; Alderson, Philip O.; Wilhelm, Jochen; Hill, Rexford L.; Markham, Joanne; Kinzie, Jeannie J.

doi:10.1378/chest.65.6.660

Cited by 24 publications

(8 citation statements)

References 10 publications

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“…Totally absent perfusion of a complete lung is a rare finding, and one should be especially aware of congenital vascular abnormalities Pulmonary veno-occlusive disease [39] Fibrotic sarcoid [42] Perfusion defect with normal ventilation Acute pulmonary embolism [6-8, 19, 33] Old pulmonary thromboembolism [44,45] Atelectasis [48] Metastatic lung disease [49] (Microscopic) tumour embolism [51,52] Post radiotherapy [54] Haemangioendotheliomatosis [56] Traumatic pulmonary artery pseudoaneurysm [58] Air embolism [61] Idiopathic pulmonary fibrosis [63,64] Oesophageal hiatus hernia [65] Positive end expiratory pressure ventilation [67] Diaphragm paralysis [69] Mitral valve disease [71] Dogworm infestation [33] Congenital vascular abnormalities [36][37][38] Tumours in the hilar region [40,41] Histoplasmosis [43] Emphysema [46,47] Pneumonia [33,42] Sarcoidosis [49] Lymphangitis carcinomatosis [50] Intravenous drug abuse [53] Pulmonary artery sarcoma [49,55] Systemic arterial supply [57] Pulmonary contusion [59,60] Takayasu's arterities [49,62] Histoplasmosis [43] Intrathoracic stomach …”

Section: High Probability Perfusion-ventilation Lung Scanmentioning

confidence: 99%

“…1) [36][37][38]. Another cause of unilateral absence of lung perfusion is a tumour mass in the hilar region [40,41]. Pulmonary veno-occlusive disease may also mimic pulmonary thromboembolism, but the ante-mortem diagnosis is difficult [39].…”

Section: High Probability Perfusion-ventilation Lung Scanmentioning

confidence: 99%

“…Bronchial carcinoma and other malignancies have been shown to cause perfusion defects [40,41,[49][50][51][52]. With centrally located tumours one can expect both matched and mismatched defects (Fig.…”

Section: High Probability Perfusion-ventilation Lung Scanmentioning

confidence: 99%

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The value of lung scintigraphy in the diagnosis of pulmonary embolism

et al. 1993

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The role of lung scintigraphy in the diagnostic management of patients with clinically suspected pulmonary embolism is reviewed. Evidence is provided that a normal perfusion scan excludes clinically relevant pulmonary embolism, and that a high probability lung scan, defined as a segmental perfusion defect with locally normal ventilation, sufficiently confirms the presence of pulmonary embolism in the majority of these patients. Furthermore, this review assesses the possibility of non-invasive tests for the diagnosis or exclusion of venous thromboembolic disease as a means of avoiding pulmonary angiography in patients with lung scan outcomes that are neither normal nor high probability.

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Section: High Probability Perfusion-ventilation Lung Scanmentioning

confidence: 99%

Section: High Probability Perfusion-ventilation Lung Scanmentioning

confidence: 99%

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The value of lung scintigraphy in the diagnosis of pulmonary embolism

et al. 1993

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“…Arborelius et al (1971) showed a close correlation between regional loss of lung function and extent of tumour growth, whilst Secker-Walker et al (1971) demonstrated a relationship between the size of the perfusion defect and the proximity of tumour to the pulmonary hilum. In a study of 26 patients with bronchial carcinomiia, a large perfusion defect in the tumour-bearing lung (relative perfusion less than 33%) was found to be a strong indication of non-resectability (Secker-Walker et al, 1974). In a similar study reported by Lipscomb and Pride (1977), including 21 patients, extensive loss oflung perfusion was, in each of three cases, associated with extensive mediastinal involvement at surgery.…”

Section: Ventilation and Perfusion Lung Scansmentioning

confidence: 78%

Pre-operative mediastinal evaluation in primary bronchial carcinoma—a review of staging investigations

Elliott

1984

Postgraduate Medical Journal

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Summary A review of staging investigations in the preoperative evaluation of mediastinal involvement in primary bronchial carcinoma is presented. The following conclusions are offered as guidelines for the use of mediastinal staging procedures in clinical practice: Surgical staging methods have the over-riding advantage of superior specificity over indirect imaging techniques. Where 67Ga-imaging or CT scanning are not available, routine pre-operative mediastinoscopy or, when appropriate, mediastinotomy will identify most patients with non-resectable disease but this approach entails a high proportion of true negative examinations. Radioisotope ventilation and perfusion lung imaging has no place in the pre-operative staging of lung cancer. Where the techniques are available, 67Ga-imaging and CT scanning have a use in selecting patients for mediastinal exploration. A negative mediastinal 67Ga scan or a negative CT examination suggest that mediastinal exploration will be unrewarding in the vast majority of cases and may be omitted prior to thoracotomy. A positive mediastinal 67Ga scan or the demonstration of abnormal mediastinal nodes by CT is an indication for mediastinal exploration which, if negative should be followed by thoracotomy.

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“…Using 133Xe radiospirometry, Arborelius et a/. Pre-operative V/Q scanning has also been used for the prediction of operability of a tumour, but data in this field are conflicting (Secker-Walker & Provan, 1969;Secker-Walker et a/., 1974, Lipscomb & Pride, 1977. The same technique has subsequently been used to predict pulmonary function after pulmectomy and lobectomy (Kristersson, Lindell & Svanberg, 1972 ; Kristersson el a/., 1973).…”

Section: B Ron Chogen Ic Carcinomamentioning

confidence: 99%

Clinical ventilation‐perfusion scintigraphy

Fazio¹,

Wollmer²

1981

Clinical Physiology

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Ventilation-perfusion scintigraphy is an established procedure for the investigation of lung disease. Perfusion scans are commonly obtained with a gamma-camera following injection of 99mTc-labelled microspheres. For the assessment of regional lung ventilation, a number of techniques are now being employed, i.e. 133Xe and 127Xe single breath/washout studies, continuous inhalation of 81mKr and inhalation of radioactive aerosols. The latter two methods are now gaining consideration in clinical practice. Lung perfusion scanning is highly sensitive for detection of regional abnormalities of blood flow; the diagnosis of pulmonary embolism remains the most important clinical application of the technique. In this context, the use of a ventilation scan is required in order to increase the specificity of the procedure. In general, lung ventilation-perfusion scintigraphy is of great value for the management of patients with both primary lung disease and heart disease, by providing pathophysiological information of importance for the diagnosis, follow up and the functional evaluation of the patient.

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Ventilation-Perfusion Scanning in Carcinoma of the Bronchus

Cited by 24 publications

References 10 publications

The value of lung scintigraphy in the diagnosis of pulmonary embolism

The value of lung scintigraphy in the diagnosis of pulmonary embolism

Pre-operative mediastinal evaluation in primary bronchial carcinoma—a review of staging investigations

Clinical ventilation‐perfusion scintigraphy

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