Ventilatory Function in Subjects with Childhood Asthma who have Become Symptom Free

Blackhall, Margaret I.

doi:10.1136/adc.45.241.363

Cited by 52 publications

(13 citation statements)

References 13 publications

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“…The studies indicating continuing abnormalities in lung function and even the presence of airway inflammation as symptoms improve are consistent with ongoing effects of asthma on the lungs that could easily predispose to adult obstructive lung disease. [32][33][34][39][40][41] The detailed comparison of children with persistent mild to moderate asthma in CAMP and children without asthma demonstrates the continuing evolution of airway obstruction as children with asthma grow into later adolescence. These abnormalities are a result of different effects by age on growth of the lung parenchyma reflected by FVC and the airways reflected by FEV 1 .…”

Section: Discussionmentioning

confidence: 98%

Mild to moderate asthma affects lung growth in children and adolescents

Strunk

Weiss

Yates

et al. 2006

Journal of Allergy and Clinical Immunology

141

106

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Section: Discussionmentioning

confidence: 98%

Mild to moderate asthma affects lung growth in children and adolescents

Strunk

Weiss

Yates

et al. 2006

Journal of Allergy and Clinical Immunology

141

106

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“…Using other forms of 'bronchial challenge', Cade and Pain (1971b) with methylcholine inhalations, Sly (1970) using a treadmill walking test, and Pierson et al (1969), during bicycle ergometer studies, also found no relation between initial spirometry and the response to challenge. Jones and Jones (1966) and Blackhall (1970) showed that EIB varied little in young ex-asthmatic subjects over several years. We have confirmed their observations, showing that the mean fall in PEFR in the group of subjects who performed 2 tests with an interval of one year, hardly altered (24 4O/ to 25 6%) and the lability index was also constant (31 -9% to 34-4%).…”

Section: Discussionmentioning

confidence: 99%

Standardization of Exercise Tests in Asthmatic Children

Silverman¹,

Anderson²

1972

Archives of Disease in Childhood

285

104

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. Standardization of exercise tests in asthmatic children. Asthmatic children, known to be susceptible to exercise-induced bronchoconstriction, exercised by running or walking on a treadmill. Changes in airways obstruction were estimated by measurement of peak expiratory flow rate before, during, and after exercise. Post exercise bronchoconstriction reached a maximum when the duration of exercise was 6 to 8 minutes and when the gradient of the treadmill was 10 to 15%; exercise for longer periods or at steeper gradients produced no significant increase in bronchoconstriction. Bronchoconstriction was much greater after running than after walking at the same oxygen consumption in 4 out of the 5 subjects tested.The reproducibility of bronchoconstriction was good in individual patients when tests performed within one day or within one week were compared. Reproducibility diminished as the interval between tests increased to one month or one year. When tests were repeated at 2-hourly intervals throughout the day, no significant diminution in exercise-induced bronchoconstriction was noted. Variations in pre-exercise peak expiratory flow rate had no significant effect on exercise-induced bronchoconstriction in individual subjects.The range of response of normal children to treadmill exercise is defined and the value of the test in discriminating between asthmatic and other children is shown.If several tests are to be carried out by an individual patient, they should be performed on separate days at the same time of day and should be completed within one week. This will allow accurate comparisons to be made between tests in, for example, the assessment of the effect of different drugs in an individual patient.

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“…Eosinophilic airways inflammation plays an important role in asthma and the current thinking is that undertreatment of airways inflammation may lead to long-term structural changes such as airways remodelling and irreversible airflow obstruction [6]. While studies have documented pulmonary function abnormalities and bronchial hyperresponsiveness in previous childhood asthmatics [2,[7][8][9][10][11], to the best of the authors9 knowledge there are no reports of persistent airways inflammation in children who have outgrown asthma. This study examined direct measures of airways inflammation in children who had had wheezing episodes in the past.…”

mentioning

confidence: 99%

Outgrown asthma does not mean no airways inflammation

Warke¹,

Fitch²,

Brown³

et al. 2002

Eur Respir J

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Although some asthmatic children seem to recover from their asthma, 30-80% develop asthma again in later life. The underlying risk factors are unknown. The hypothesis for this study was that children with apparently outgrown asthma would have underlying airway inflammation.Nonbronchoscopic bronchoalveolar lavage was performed on normal children (n=35) and children who had wheezed previously (n=35).Eosinophils were raised in the lavage fluid of atopic children who had apparently outgrown asthma (median (interquartile range) 0.36 (0.05-0.74) compared to controls 0.10 (0-0.18), p=0.002). There was no relationship between length of remission and degree of airways eosinophilia.Thus, there is persistent airways inflammation in some children with outgrown asthma and this may be a risk factor for future relapse.

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Ventilatory Function in Subjects with Childhood Asthma who have Become Symptom Free

Cited by 52 publications

References 13 publications

Mild to moderate asthma affects lung growth in children and adolescents

Mild to moderate asthma affects lung growth in children and adolescents

Standardization of Exercise Tests in Asthmatic Children

Outgrown asthma does not mean no airways inflammation

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