1972
DOI: 10.1042/cs0430861
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Ventilatory Response to Exercise and to Co2 Rebreathing in Normal Subjects

Abstract: S U M M A R Y1. Changes in ventilation during progressive exercise were measured in eleven normal subjects. Ventilatory response to carbon dioxide at rest was measured in the same subjects using a rebreathing method.2. The range of ventilatory response to exercise was 16.6-32.0 litres min-' (litres CO, min-')-' (mean 22.7; SD 5.35); response to 0, uptake was 17.0-43-9 litresmin-'(litres 0, min-')-' (mean29.02; SD 9.07). Ventilatory response to CO, (Sco,) ranged from 0.81 to 3.22 litre min-' mmHg-' (mean 1-87; … Show more

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Cited by 60 publications
(26 citation statements)
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“…The ventilatory response to hypercapnia correlates to the ventilatory response to exercise in normal subjects and athletes 4,5,10 ; we extend this observation to patients after heart transplantation. However, the ventilatory response from central chemoreceptors was strictly normal in these HTRs.…”
Section: Exercise Hyperpneamentioning
confidence: 90%
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“…The ventilatory response to hypercapnia correlates to the ventilatory response to exercise in normal subjects and athletes 4,5,10 ; we extend this observation to patients after heart transplantation. However, the ventilatory response from central chemoreceptors was strictly normal in these HTRs.…”
Section: Exercise Hyperpneamentioning
confidence: 90%
“…1 Peripheral chemoreceptors also play an important modulatory role in the regulation of ventilation during exercise. [2][3][4][5] This is evidenced by the observation that breathing oxygen decreases ventilation and increases arterial carbon dioxide to a greater extent during exercise than at rest. 6,7 Central chemoreceptors are located in the brain stem and respond primarily to hypercapnia.…”
mentioning
confidence: 99%
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“…LINTON et al (1973) Other causes for the decreased slopes in the VE-PACO2 line during exercise may be various factors such as arterio-alveolar CO2 difference((a-A)DCO 2), CO2 storage capacity,and central or peripheral chemosensitivity . JONES et al (1969JONES et al ( ,1972showed that the arterial PCO2 was consistently lower than the alveolar PCO2 during rebreathing of CO2+O2 mixture.This reversed(a-A)DCO 2 might partially account for the apparent decrease in the slope of the VE-PACO2 curves.…”
Section: Resultsmentioning
confidence: 99%
“…The chemoreceptors thought to be responsible for sensing 02 and C02 occupy different areas in the nervous system, yet their sensitivities are apparently well matched; subjects with the most marked ventilatory responses to hypoxia have the greater ventilatory responses to C02 and to rhythmic dynamic exercise (Rebuck, Kangalee, Pengelly & Campbell, 1973;Rebuck, Jones & Campbell, 1972). As regards carbon dioxide, although both tidal volume and frequency of breathing increase during progressive hypercapnia, the variable that correlates better with the over-all ventilatory response to CO2 appears to be tidal volume response (Rebuck, Rigg, Kangalee & Pengelly, 1974).…”
Section: Introductionmentioning
confidence: 99%