Ventricular-arterial coupling in systemic lupus erythematosus women without cardiovascular risk factors

Sciatti, Edoardo; Cavazzana, Ilaria; Franceschini, Franco; Vizzardi, Enrico

doi:10.1177/09612033221093491

Cited by 3 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HsTn is a well-known biomarker of myocardial injury. After excluding obvious acute, subacute or chronic cardiac complications, like myocarditis or myocardial infarction, hsTn may be found elevated in SLE implicating cardiac involvement [14]. In agreement with recent research, our study verified increased hsTn levels in SLE patients characterized by lack of apparent kidney or cardiac dysfunction and a low CV risk profile [12].…”

Section: Discussionsupporting

confidence: 91%

“…Recently, the PWV/GLS ratio has been proposed as a reliable, feasible, easily performed, and reproducible index of VAC with prognostic value [13]. However, very scarce data exist about the impact of SLE on VAC [14]. From the clinical perspective the early identification of cardiovascular dysfunction with impaired VAC could stratify the cardiovascular risk and determine the therapeutic management of SLE.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematous

Kadoglou,

Dimopoulou,

Gkougkoudi

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an increased risk of cardiovascular diseases (CVD), leading to elevated mortality rates among patients. We aimed to evaluate the levels of cardio-ankle vascular index (CAVI), global longitudinal strain (GLS), ventricular-arterial coupling (VAC) and high-sensitivity cardiac troponin (hsTn), in SLE patients and to explore their relationship with clinical parameters. Methods: This cross-sectional study enrolled 82 SLE patients without evident cardiac or kidney impairment and 41 age- and sex matched healthy controls. We comparatively evaluated CAVI, GLS, VAC, and hsTn between SLE patients and controls, and we assessed their association among SLE patients with disease activity based on the SELENA-SLEDAI Activity Index. Multivariate regression analysis was performed to identify independent predictors of CAVI and hsTn within the SLE cohort. Results: In comparison to healthy controls, SLE patients presented with significantly higher CAVI, GLS and hsTn levels, while VAC was significantly reduced (p&lt;0.001). Further, SLE patients with active disease (SELENA-SLEDAI≥4) exhibited higher levels of CAVI and troponin than those with inactive disease (p&lt;0.001). SLEDAI was an independent predictor of CAVI, while VAC and SLEDAI were independent determinants of hsTn in SLE cohort. Conclusion: SLE patients displayed abnormal levels of CAVI, VAC, GLS, and troponin compared to healthy individuals. Our findings implicate the potential of those CV novel CVD risk factors to refine screening and therapeutic strategies for this specific population.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematous

Kadoglou,

Dimopoulou,

Gkougkoudi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…HsTn is a well-known biomarker of myocardial injury. After excluding obvious acute, subacute, or chronic cardiac complications, like myocarditis or myocardial infarction, hsTn may be found elevated in SLE implicating most usually cardiac involvement or other extra-cardiac causes which was difficult to identify and rule out in our study [16]. In agreement with recent research, our study verified increased hsTn levels in SLE patients characterized by a lack of apparent kidney or cardiac dysfunction and a low CV risk profile [14].…”

Section: Discussionsupporting

confidence: 81%

“…Recently, the PWV/GLS ratio has been proposed as a reliable, feasible, easily performed, and reproducible index of VAC with prognostic value [15]. However, very scarce data exist about the impact of SLE on VAC [16]. From the clinical perspective, the early identification of cardiovascular dysfunction with impaired VAC could stratify the cardiovascular risk and determine the therapeutic management of SLE.…”

Section: Introductionmentioning

confidence: 99%

Altered Arterial Stiffness, Ventricular–Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematosus

Kadoglou,

Dimopoulou,

Gkougkoudi

et al. 2024

Medicina

View full text Add to dashboard Cite

Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease associated with an increased risk of cardiovascular diseases (CVDs), leading to elevated mortality rates among patients. We aimed to evaluate the levels of cardio–ankle vascular index (CAVI), global longitudinal strain (GLS), ventricular–arterial coupling (VAC), and high-sensitivity cardiac troponin I (hsTnI) in SLE patients and to explore their relationship with clinical parameters. Methods: This cross-sectional study enrolled 82 SLE patients without evident cardiac or kidney impairment and 41 age- and sex-matched healthy controls. We comparatively evaluated CAVI, GLS, VAC, and hsTnI between SLE patients and controls, and we assessed their association among SLE patients with disease activity based on the SELENA–SLEDAI Activity Index. Multivariate regression analysis was performed to identify independent predictors of CAVI and hsTnI within the SLE cohort. Results: In comparison to healthy controls, SLE patients presented with significantly higher CAVI, GLS, and hsTnI levels, while VAC was significantly reduced (p < 0.001). Furthermore, SLE patients with active disease (SELENA–SLEDAI ≥ 4) exhibited higher levels of CAVI and troponin than those with inactive disease (p < 0.001). SLEDAI was an independent predictor of CAVI, while VAC and SLEDAI were independent determinants of hsTnI in the SLE cohort. Conclusions: SLE patients displayed abnormal levels of CAVI, VAC, GLS, and troponin compared to healthy individuals. Our findings implicate the potential of those CV novel CVD risk factors to refine screening and therapeutic strategies for this specific population.

show abstract

“…These findings are consistent with previous studies that report reduced GLS values in SLE patients compared with controls, including one of SLE patients without traditional cardiovascular risk factors, where they identified alteration of GLS (> À18.5%) in 47% of SLE patients which is consistent with our results. 10,11 However, to our knowledge, this study is the first to classify Hispanic SLE patients with a GLS level higher than À18 as subclinical left ventricular systolic dysfunction and compare them with a control group. Under normal conditions, GLS values are lower than À18%.…”

Section: Discussionmentioning

confidence: 93%

Subclinical systolic dysfunction by speckle tracking echocardiography in patients with systemic lupus erythematosus

Azpiri-López

Galarza‐Delgado

Garza-Cisneros

et al. 2022

Lupus

View full text Add to dashboard Cite

Background We aimed to compare the prevalence of subclinical left ventricular systolic dysfunction in Hispanic systemic lupus erythematosus (SLE) patients versus healthy controls. Material and methods This cross-sectional study included 46 SLE patients who fulfilled the 2019 European League Against Rheumatism and American College of Rheumatology (EULAR/ACR) classification criteria for SLE and with age ≥ 18 years. For comparison, we included a control group with 46 non-SLE subjects matched by age (±5 years) and gender. A transthoracic echocardiogram was performed on every participant. The echocardiographic measurements evaluated were left ventricular ejection fraction (LVEF), relative wall thickness (RWT), and tricuspid annular plane systolic excursion (TAPSE). Left ventricular-Global Longitudinal Strain (GLS) was evaluated, and a value higher than −18% was classified as subclinical left ventricular systolic dysfunction. Comparisons between groups were made using the Chi-square test or Fisher’s exact test for qualitative variables, and Student’s t-test or the Mann–Whitney’s U test for quantitative variables. A p-value <.05 was considered significant. Results We found a significant difference in the presence of subclinical left ventricular systolic dysfunction between SLE-patients and controls (37.0% vs 8.7%, p = .001). We also found that SLE patients had a lower left ventricular GLS (−18.90% vs −20.51%, p = .011), TAPSE (21.63 mm vs 23.60 mm, p = .009), and LVEF (57.17% vs 62.47%, p = <.001) than controls. Systemic lupus erythematosus diagnosis was independently associated with the presence of subclinical left ventricular systolic dysfunction with an OR of 6.068 (CI 95% 1.675−21.987) ( p = .006). Subclinical systolic dysfunction was more common in men (29.4% vs 3.4%, p = .020), patients with obesity (17.6% vs 0%, p = .045), or hypertension (47.1% vs 6.9%, p = .001). Conclusion Systemic lupus erythematosus Hispanic patients had a higher prevalence of subclinical left ventricular systolic dysfunction, and worse left ventricular GLS, LVEF, and TAPSE values than matched healthy controls. Additionally, we found that male gender, obesity, and hypertension are associated with the presence of subclinical left ventricular systolic dysfunction in SLE patients. The inclusion of speckle tracking echocardiography as part of the cardiovascular evaluation of SLE patients may help identify high cardiovascular risk patients.

show abstract

Ventricular-arterial coupling in systemic lupus erythematosus women without cardiovascular risk factors

Cited by 3 publications

References 10 publications

Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematous

Altered Arterial Stiffness, Ventricular-Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematous

Altered Arterial Stiffness, Ventricular–Arterial Coupling and Troponin Levels in Patients with Systemic Lupus Erythematosus

Subclinical systolic dysfunction by speckle tracking echocardiography in patients with systemic lupus erythematosus

Contact Info

Product

Resources

About