Ventricular dilatation in ex-prematures: only confined to the occipital region? MRI-based normative standards for 19-year-old ex-prematures without major handicaps

Aukland, Stein Magnus; Elgen, Irene Bircow; Odberg, Morten Duus; Chong, WK; Eide, Geir Egil; Rosendahl, Karen

doi:10.1177/0284185113497476

Cited by 3 publications

(7 citation statements)

References 29 publications

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“…In addition, we assessed peritrigonal white matter thickness. In the present study, children born preterm had an increased Evans index and posterior ventricle index compared to the children born at term, which is in line with previous studies [ 5 , 17 , 23 , 24 ]. Skranes et al found a dilatation of the ventricle system in 82% of adolescents born ≤1500g in 1986–1988 compared to 21% of controls at the age of 15 years.…”

Section: Discussionsupporting

confidence: 93%

Brain MRI findings and their association with visual impairment in young adolescents born very preterm

Karimi,

Setänen,

Larsson

et al. 2023

Neuroradiology

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Purpose Very preterm birth increases risk for neonatal white matter injury, but there is limited data on to what extent this persists into adolescence and how this relates to ophthalmological outcomes. The aim of this study was to assess brain MRI findings in 12-year-old children born very preterm compared to controls and their association with concurrent ophthalmological outcomes. Methods We included 47 children born very preterm and 22 full-term controls (gestational age <32 and >37 weeks, respectively). Brain MRI findings were studied in association with concurrent ophthalmological outcomes at 12-year follow-up. Results Evans index (0.27 vs 0.25, p<0.001) and a proposed “posterior ventricle index” (0.47 vs 0.45, p=0.018) were increased in children born very preterm. Higher gestational age associated with larger corpus callosum area (β=10.7, 95%CI 0.59–20.8). Focal white matter lesions were observed in 15 (32%) of very preterm children and in 1 (5%) of full-term controls. Increased posterior ventricle index increased risk for visual acuity ≤1.0 (OR=1.07×1011, 95%CI=7.78–1.48×1021) and contrast sensitivity <0.5 (OR=2.6×1027, 95%CI=1.9×108–3.5×1046). Decreased peritrigonal white matter thickness associated with impaired visual acuity (β=0.04, 95%CI 0.002–0.07). Conclusion More white matter lesions and evidence of lower white matter volume were found in children born very preterm compared with full-term controls at 12-year follow-up. The association between larger posterior ventricle index and reduced visual acuity and contrast sensitivity suggests disturbances of the posterior visual pathway due to diffuse white matter lesions.

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Section: Discussionsupporting

confidence: 93%

Brain MRI findings and their association with visual impairment in young adolescents born very preterm

Karimi,

Setänen,

Larsson

et al. 2023

Neuroradiology

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“…Our study confirms the results of other studies that describe the adult preterm brain from a neuroradiological perspective [28][29][30][31]. We could confirm the smaller head size and the posterior dilatations of the lateral ventricles described by Aukland et al [28] and Bjuland et al [29], the lower volume of the posterior corpus callosum reported by Bjuland et al [29], the thinner corpus callosum and the white matter alterations described by Odberg et al [31].…”

Section: Discussionsupporting

confidence: 92%

“…Some authors found that preterm born infants have a higher prevalence of head shape abnormalities such as elongated head shape (dolichocephaly) [48]. Additionally, regional biometric differences reflecting impaired cerebellar size or deviating head diameters were reported in children [49] and adults [28] born preterm and may be associated with cognitive and motor outcomes [49].…”

Section: Discussionmentioning

confidence: 99%

“…VLBW adults have a higher incidence of neurosensory deficits, a greater burden of illness, lower IQ scores, and poorer educational achievement than their peers born with normal birth weight [12,[24][25][26] and lower quality of life [27]. However, few studies describe the adult preterm brain from a neuroradiological perspective [28][29][30][31]. We hypothesized that the brain abnormalities still present in adulthood would form a specific MRI pattern related to premature birth.…”

Section: Introductionmentioning

confidence: 99%

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Automated quantitative evaluation of brain MRI may be more accurate for discriminating preterm born adults

et al. 2019

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Objective To investigate the structural brain abnormalities and their diagnostic accuracy through qualitative and quantitative analysis in term born and very preterm birth or with very low birthweight (VP/VLBW) adults. Methods: We analyzed 3T MRIs acquired 2011-2013 from 67 adults (27 term born controls, mean age 26.4 years, 8 females; 40 VP/VLBWs, mean age 26.6 years, 16 females). We compared automatic segmentations of white matter, deep grey matter and cortical grey matter, manual corpus callosum measurements and visual ratings of the ventricles and white matter with t-tests, logistic regression and receiver operator characteristic (ROC) curves. Results: Automatic segmentation correctly classified 84% of cases; visual ratings correctly classified 63%. Quantitative volumetry based on automatic segmentation revealed higher ventricular volume, lower posterior corpus callosum and deep grey matter volumes in VP/VLBW subjects compared to controls (P<0.01). Visual rating and manual measurement revealed a thinner corpus callosum in VP/VLBW adults (P=0.04), deformed lateral ventricles (P=0.03) and tendency towards more "dirty" white matter (P=0.06). Automatic/manual measures combined with visual ratings correctly classified 87% of cases. Stepwise logistic regression identified three independent features that correctly classify 81% of cases: ventricular volume, deep grey matter volume and white matter aspect. Conclusion: Enlarged and deformed lateral ventricles, thinner corpus callosum and "dirty" white matter are prevalent in preterm born adults. Their visual evaluation has low diagnostic accuracy. Automatic volume quantification is more accurate but time consuming. It may be useful to ask for prematurity before initiating further diagnostics in subjects with these alterations.

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“…Comparing three approaches regarding the evaluation of LV size in young adults, we have identified the FOHR as the most accurate measure being feasible in clinical routine [ 30 ]. This superior accuracy of the FOHR is most likely caused by occipital horn dilatation in prematurely born adults which was described previously [ 39 ].…”

Section: Discussionsupporting

confidence: 59%

Sequelae of Premature Birth in Young Adults

et al. 2020

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Background and Purpose Qualitative studies about the abnormalities appreciated on routine magnetic resonance imaging (MRI) sequences in prematurely born adults are lacking. This article aimed at filling this knowledge gap by (1) qualitatively describing routine imaging findings in prematurely born adults, (2) evaluating measures for routine image interpretation and (3) investigating the impact of perinatal variables related to premature birth. Methods In this study two board-certified radiologists assessed T1-weighted and FLAIR-weighted images of 100 prematurely born adults born very preterm (VP <32 weeks) and/or at very low birth weight (VLBW <1500 g) and 106 controls born at full term (FT) (mean age 26.8 ± 0.7 years). The number of white matter lesions (WML) was counted according to localization. Lateral ventricle volume (LVV) was evaluated subjectively and by measurements of Evans' index (EI) and frontal-occipital-horn ratio (FOHR). Freesurfer-based volumetry served as reference standard. Miscellaneous incidental findings were noted as free text. Results The LVV was increased in 24.7% of VP/VLBW individuals and significantly larger than in FT controls. This was best identified by measurement of FOHR (AUC = 0.928). Ventricular enlargement was predicted by low gestational age (odds ratio: 0.71, 95% CI 0.51-0.98) and presence of neonatal intracranial hemorrhage (odds ratio: 0.26, 95% CI 0.07-0.92). The numbers of deep and periventricular WML were increased while subcortical WMLs were not. Conclusion Enlargement of the LVV and deep and periventricular WMLs are typical sequelae of premature birth that can be appreciated on routine brain MRI. To increase sensitivity of abnormal LVV detection, measurement of FOHR seems feasible in clinical practice.

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Ventricular dilatation in ex-prematures: only confined to the occipital region? MRI-based normative standards for 19-year-old ex-prematures without major handicaps

Cited by 3 publications

References 29 publications

Brain MRI findings and their association with visual impairment in young adolescents born very preterm

Brain MRI findings and their association with visual impairment in young adolescents born very preterm

Automated quantitative evaluation of brain MRI may be more accurate for discriminating preterm born adults

Sequelae of Premature Birth in Young Adults

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