Ventricular electrical instability in the conscious dog

Matta, Raymond J.; Lawler, J. E.; Lown, Bernard

doi:10.1016/s0002-9149(76)80008-2

Cited by 72 publications

(7 citation statements)

References 29 publications

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“…Concomitant with the changes in circulating adrenergic neurohumoral agents there was a significant decrease in the ventricular vulnerable threshold. These observations in conjunction with the findings that changes in ventricular RE response resulting from diverse psychologic stresses can be annulled by such P-adrenergic blocking drugs as tolamolol (6) or propranolol (7) indicate that these psychologically induced electrophysiologic alterations are mediated largely by the sympathetic nervous system.…”

Section: -mentioning

confidence: 80%

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Correlation between Circulating Catecholamine Levels and Ventricular Vulnerability during Psychological Stress in Conscious Dogs

Liang

Verrier

Melman

et al. 1979

Experimental Biology and Medicine

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Section: -mentioning

confidence: 80%

“…P-Adrenergic blockade (6,7) or stellectomy (7) significantly reduce or entirely prevent expression of psychologically initiated changes on ventricular vulnerability to fibrillation. It is suggested that the level of sympathetic tone mediates cardiac susceptibility to varying ventricular arrhythmias.…”

mentioning

confidence: 99%

Correlation between Circulating Catecholamine Levels and Ventricular Vulnerability during Psychological Stress in Conscious Dogs

Liang

Verrier

Melman

et al. 1979

Experimental Biology and Medicine

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“…Amongst these are the cardiac consequences of accelerated atherosclerosis and, as mounting evidence suggests, a predisposition towards the development of AF (24-25). Previous studies of both animal models and humans suggest a relationship between psychosocial stress and ventricular tachycardia (VT), which is driven in part by upregulation of the sympathetic nervous system (26-28). Canine models, in particular, have demonstrated an increased susceptibility to VT with psychosocial stress, a susceptibility that resolves following beta-blocker treatment (26).…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Psychosocial Stressors and Atrial Fibrillation in Women >45 Years of Age

Westcott

Beach

Matsushita

et al. 2018

The American Journal of Cardiology

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Negative emotions have been linked to the development of atrial fibrillation (AF), and positive effect may be protective. However, there are few large-scale studies examining the association between psychosocial stressors that may provoke these emotions and the occurrence of AF. We examined the cross-sectional relation between psychosocial stress and AF in 24,809 women participating in the Women's Health Study. Participants answered questions about work stress (e.g., excessive work, conflicting demands), work-family spillover stress (e.g., too stressed after work to participate in activities with family), financial stress (e.g., difficulty paying monthly bills), traumatic life events (e.g., death of a child), everyday discrimination (e.g., less respect, poor service), intimate partner stress (e.g., how judgmental is your spouse/partner), neighborhood stress (e.g., neighborhood safety, trust), negative life events within 5 years (e.g., life threatening illness, legal problems), and cumulative stress (a weighted measure of the stress domains). The prevalence of confirmed AF was 3.84% (N = 953) and risk factor profiles differed by AF status. Women with AF reported significantly higher financial stress, traumatic life events, and neighborhood stress (p < 0.05). Only traumatic life events (odds ratio 1.37, 95% confidence interval 1.19 to 1.59) was significantly associated with AF after adjustment for cardiovascular risk factors, socioeconomic and psychosocial status. These large-scale cross-sectional data thus indicate a potential relationship between traumatic life events and AF in older women.

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“…Moreover, the measurement of trait-level psychological constructs such as perceived social support (27), distress (11), and depression may have been confounded by state-dependent factors (19). Experimental studies manipulating state-dependent psychological factors have demonstrated an association between induced states of emotional arousal and increased levels of VPBs (2,29), indicating that changes in arousal, not trait levels, may be associated with increased levels of VPBs.…”

Section: Discussionmentioning

confidence: 99%