Ventricular electrophysiology in congestive heart failure and its correlation with heart rate variability and baroreflex sensitivity: a canine model study

Songyang, Zhou; Liu, Juan; Chang, Fang; Zhang, Yuling; Wang, Jingfeng

doi:10.1093/europace/eun383

Cited by 15 publications

(14 citation statements)

References 24 publications

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“…Enhanced neovascularization in mild/moderate heart failure CD31 is a pan-endothelial marker, whereas CD105 preferentially reacts with "newly forming" vessels [16][17][18]. Hence, CD31 was used to assess total MVD and CD105 was used to assess neovascularization in this study.…”

Section: Resultsmentioning

confidence: 99%

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Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines

et al. 2014

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Neovascularization plays pivotal role in ischemic heart failure; however, it is unclear in non-ischemic heart failure. Non-ischemic heart failure was induced by chronic rapid right ventricular pacing at 200 beats/min, respectively, for 3 and 6 weeks in 12 dogs. Sham-operation was performed in another 6 dogs as control. Three-week tachycardia pacing could induce mild/moderate heart failure and 6-week pacing could induce severe heart failure. Pan-microvessel density (MVD) was assessed by CD31 and neovascularization density was assessed by CD105. Mean CD31-MVD and CD105-MVD were significantly increased after 3-week pacing. However, CD105-MVD was significantly decreased by 80 % in 6-week pacing group compared with 3-week pacing group, whereas CD31-MVD was only decreased slightly (15 %; P < 0.05). Myocardial proangiogenic factor stromal cell-derived factor 1 (SDF-1), hypoxia-inducible factors 1α (HIF-1α, a transcription factor which could regulate SDF-1 expression), serum SDF-1 levels and circulating EPC mobilization were greatly elevated after 3-week pacing but nearly returned to baseline level after 6-week pacing, which were in accordance with the changes of neovascularization levels assessed by CD105. Angiogenesis and migrating ability of EPCs were enhanced after stimulation of SDF-1, which could be abolished by pretreatment with SDF-1 receptor antagonist AMD3100. In addition, angiogenesis and migrating functions of EPCs were significantly enhanced by the serum from 3-week pacing dogs, but had much weaker response to the serum from 6-week pacing dogs. In conclusion, tachycardia pacing-induced non-ischemic heart failure, promoted myocardial neovascularization and mobilized circulating EPCs, which might be mediated partly through SDF-1 pathway.

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Section: Resultsmentioning

confidence: 99%

“…The method of inducing heart failure has recently been reported in detail previously [17]. Briefly speaking, anesthesia was induced with sodium pentobarbital (30 mg/kg intravenous) and maintained by isoflurane (0.5-1 % in O 2 /N 2 O [1:2]).…”

Section: Animal Modelmentioning

confidence: 99%

Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines

et al. 2014

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“…Similar phenomenon was previously observed in tachycardiomyopathic dogs. However, in a study, conducted by Zhou et al, VERP was determined once, after 4-5 weeks of rapid pacing at 240 bpm [8]. Prolonged VERP and incomplete repolarization may contribute to the development of early after-depolarizations and trigger arrhythmias [9].…”

Section: Discussionmentioning

confidence: 99%

Ventricular Effective Refraction Period and Ventricular Repolarization Analysis in Experimental Tachycardiomyopathy in Swine

et al. 2016

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“…In this study, a correlation was found between BEI and QTVI. 26 Reduced parasympathetic nervous activity and increased sympathetic nervous activity may contribute both to an increase in QTVI and to a reduction in BEI.…”

Section: Discussionmentioning

confidence: 99%

Elevated Myocardial Repolarization Lability and Arterial Baroreflex Dysfunction in Healthy Individuals With Nondipping Blood Pressure Pattern

Myredal

Friberg

Johansson

2010

American Journal of Hypertension

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Ventricular electrophysiology in congestive heart failure and its correlation with heart rate variability and baroreflex sensitivity: a canine model study

Abstract: These results suggest that ventricular electrophysiological characteristics correlated with abnormal autonomic nerve function may have important effects on sudden cardiac death. Further research is warranted.

Cited by 15 publications

References 24 publications

Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines

Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines

Ventricular Effective Refraction Period and Ventricular Repolarization Analysis in Experimental Tachycardiomyopathy in Swine

Elevated Myocardial Repolarization Lability and Arterial Baroreflex Dysfunction in Healthy Individuals With Nondipping Blood Pressure Pattern

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