Ventricular fibrillation induced by 2-aminoethoxydiphenyl borate under conditions of hypoxia/reoxygenation

Kharkovskaya, Е.Е.; Osipov, Grigory V.; Мухина, И.В.

doi:10.23736/s0026-4725.20.05376-1

Cited by 4 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Boron nitride (BN) nanoparticles and different formulations could be good candidates for biomedicines. Liu et al reported that BN nanoparticles coated by PEG (BN-PEG) highly were distributed in the heart tissue and caused high toxic effects histopathologically [34][35][36].…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Boron and Boron-Containing Compounds Toxicity

Sevim¹,

Kara²

2022

The Toxicity of Environmental Pollutants

View full text Add to dashboard Cite

Boron is an important element found in limited resources on earth, especially in Turkey, and is essential for living organisms. Boron plays key roles in human and animal systems. While boron shows its important effects as an essential element at low concentrations in the organism, it causes different toxic effects to occur at high concentrations. There are different studies on boron and boron-containing compounds effects on organisms, toxic effects mechanisms need to be detailed. Boron and its compounds can cause toxic effects in oral, dermal, and inhalation exposure and even deadly effects at very high concentrations. The use of disinfectant and cleaning products containing boron as sprays, fertilizers, etc., during the Covid-19 pandemic also increases the interest in this issue. Boron exposure could cause lung irritation, dermal irritation, genotoxicity in male reproductive system, teratogenicity in concentration-dependent manner. In vitro studies have tried to explain the toxic effects mechanisms. The aim of the current work is to explain the toxic effect mechanisms of boron and boron compounds on body systems.

show abstract

Section: Cardiovascular Systemmentioning

confidence: 99%

Boron and Boron-Containing Compounds Toxicity

Sevim¹,

Kara²

2022

The Toxicity of Environmental Pollutants

View full text Add to dashboard Cite

show abstract

Untitled

2024

Advances in Neural Computation, Machine Learning, and Cognitive Research VIII

View full text Add to dashboard Cite

Use of deep learning algorithms for segmentation of microelectrode arrays electrograms in the study of changes in myocardial bioelectrical activity

Kotikhina,

Karchkov,

Moskalenko

et al. 2024

Preprint

View full text Add to dashboard Cite

The using of modern electrophysiological methods during scientific research implies processing of huge data sets which becomes a significant problem. Progress in the development of equipment for registration of multiple local field potentials from the tissue surface contributes to the study of spatio-temporal characteristics of myocardial bioelectrical activity at a more detailed level. But it also raises the need for automation of data analysis, which can be accomplished by algorithms based on machine learning. New scientific approaches can contribute to the discovery of new facts about substances widely used but with under-researched efficacy. The paper presents the results of epicardial mapping by flexible microelectrode arrays of myocardium of isolated rat heart perfused with a solution containing L-carnitine, nutritional supplement that may be recommended for people suffering from cardiovascular disease. Electrograms from microelectrode arrays were analyzed using a neural network model based on U-Net architecture adapted for segmentation of one-dimensional signal. It was shown that the presence of L-carnitine in the perfusion solution caused a decrease in heart rate, myocardial excitation conduction velocity, coronary blood flow intensity of the isolated rat heart and suppressed physiological responses of the heart to adrenaline stimulation.

show abstract

Ventricular fibrillation induced by 2-aminoethoxydiphenyl borate under conditions of hypoxia/reoxygenation

Cited by 4 publications

References 47 publications

Boron and Boron-Containing Compounds Toxicity

Boron and Boron-Containing Compounds Toxicity

Untitled

Use of deep learning algorithms for segmentation of microelectrode arrays electrograms in the study of changes in myocardial bioelectrical activity

Contact Info

Product

Resources

About