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The aim of the study was to apply the multi-electrode mapping method to investigate the effect of 2-aminoethoxydiphenyl borate (2-apb) on the electrical activity and vessels of the isolated rat heart under hypoxia/reoxygenation injury (H/R). To date, the ability to influence on the calcium currents and condition of gap junctions has been shown for 2-apb. Changes in the intracellular calcium concentration in the heart play the pivotal role in the development of H/R.As a result, it was shown that 2-apb influences on the myocardial conduction velocity, sinus rhythm and coronary blood flow in the isolated rat heart. 2-apb caused heart fibrillation during normoxia but not under hypoxia, and attenuated the effect of the H/R on heart rate and vascular function.