Ventricular function and high-sensitivity cardiac troponin T in preterm infants with neonatal sepsis

Abstract

Background Hemodynamic instability in sepsis, especially in the neonatal population, is one of the leading causes of death in hospitalized infants. The major contribution for heart dysfunction in neonatal sepsis is the myocardial dysfunction that leads to decreasing of ventricular function. The combination of echocardiography and laboratory findings help us to understand the ventricular condition in preterm infants with sepsis.Objective To assess for a correlation between ventricular function and serum high-sensitivity cardiac troponin T (hs-cTnT) level in preterm infants with neonatal sepsis.

Clinical and haemodynamic characteristics of preterm infants with early onset sepsis

“…Various observational studies have assessed the haemodynamic response to LOS but few provided descriptive evidence of the haemodynamic presentation, clinical course of EOS and the progression to septic shock in this vulnerable age group 5–10,13–15 . Our clinical and ultrasound observational data revealed that preterm infants with EOS presented with either normal clinical findings and haemodynamic cardiac ultrasound parameters within the reference range, or with hypotension and higher as expected blood flows suggestive of warm shock.…”

“…The cardiovascular transition from fetus to newborn is a complex haemodynamic situation where many changes in lung compliance, cardiac function and vascular tone are expected. There is limited data on the clinical and haemodynamic presentation of EOS in newborns, especially for preterm infants 5,6 . In studies of preterm neonates with late‐onset sepsis (LOS), the predominant haemodynamic presentation was high cardiac output and low systemic vascular resistance 7,8 .…”

“…There is limited data on the clinical and haemodynamic presentation of EOS in newborns, especially for preterm infants. 5,6 In studies of preterm neonates with late-onset sepsis (LOS), the predominant haemodynamic presentation was high cardiac output and low systemic vascular resistance. 7,8 Our hypothesis was that preterm infants with EOS would behave similarly.…”