SUMMARY The importance of the site of stimulation to the initiation of sustained ventricular tachyarrhythmias was determined in 24 adult mongrel dogs. Studies were performed 3-30 days after two-stage occlusion of the mid-or distal left anterior descending coronary artery, modified by a reperfusion stage. Unipolar cathodal stimuli of twice-threshold intensity and 2 msec duration were introduced at five to 24 sites in each dog in the distribution of occluded and nonoccluded vessels. Strength-interval curves were constructed from 232 measurements at these sites and local properties of excitability and refractoriness were correlated with the ability to initiate arrhythmias. All dogs had sustained ventricular tachyarrhythmias inducible from at least one site. Intramyocardial sites with normal excitability and refractoriness within 2 cm of an area of infarction were most often successful (27 of 44, 61%) in the initiation of sustained arrhythmias. Less Materials and Methods Studies were performed on 24 healthy adult mongrel dogs that weighed 8-16 kg. The dogs were anesthetized with i.v. sodium pentobarbital (30 mg/kg) and then ventilated with room air through a cuffed pharyngeotracheal tube using a volume-cycled positive-pressure respirator. Body temperature was maintained with a thermal mattress. Using routine surgical procedures, the heart was exposed through a limited (< 4 cm) left thoracotomy at the fourth left intercostal space, the pericardium opened and a pericardial sling created. All dogs underwent two-stage occlusion of the mid-or distal left anterior descending coronary artery, followed by reperfusion after 2 hours of complete occlusion. Reestablishment of pulsatile arterial blood flow distal to the site of occlusion was evident in each case. Five minutes before release, dogs were pretreated with a bolus of i.v. 776