Ver�nderungen der Calcium- und Magnesiumkonzentrationen im Plasma und in Erythrocyten w�hrend der H�modialyse

Paschen, K.; Henning, Hans; Quellhorst, E; Scheler, F.

doi:10.1007/bf01495517

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…Although the concentration of magnesium in the erythrocytes of patients undergoing maintenance haemodialysis treatment has been reported to be high [3,10,16], as was found here, the extent by which that concentration can be altered through manipulation of the dialysate constituents remains to be established. The present results suggest that, in the short term, a dialysisinduced reduction in plasma magnesium is associated with a decrease in…”

mentioning

confidence: 78%

“…Hypermagnesaemia has long been associated with renal failure [18], Hypermagnesaemia often persists during the treatment of renal failure by mainten ance haemodialysis [2,14,16,17], The decrease in plasma magnesium con centration which results when magnesium is omitted from the dialysate has already been described [7,23]. It is generally agreed that it is the relatively high magnesium concentration of orthodox dialysate, 1.50 mEq/1 [4], com pared with a normal plasma-difTusable magnesium concentration of around 1.27 mEq/l, which is at least in part responsible for the hypermagnesaemia [2,7,15,17,19], The return to near normality on low magnesium dialysis, described here, supports this view.…”

Section: Plasma and Erythrocyte Magnesiummentioning

confidence: 99%

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The Effect of Dialysate Magnesium on Plasma and Erythrocyte Magnesium and Potassium Concentrations during Maintenance Haemodialysis

Stewart¹,

Fleming²

1973

Nephron

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The effects on plasma and erythrocyte potassium and magnesium concentrations of low ( < 0.2 mEq/l) as compared with orthodox (1.50 mEq/l) dialysate magnesium concentrations have been studied in six patients on maintenance haemodialysis. On low magnesium dialysis, plasma magnesium concentrations were significantly decreased from hypermagnesaemic to normal levels but the high erythrocyte magnesium concentrations were unchanged. The plasma potassium decrease, usual during each dialysis, was unaffected. In contrast, erythrocyte potassium concentrations, which did not change during individual dialyses, were high when orthodox magnesium was present in the dialysate, and normal during low magnesium dialysis. Low magnesium dialysis has biochemical advantages in that it corrects hypermagnesaemia and maintains normal erythrocyte potassium concentrations which otherwise would be increased.

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confidence: 78%

Section: Plasma and Erythrocyte Magnesiummentioning

confidence: 99%

The Effect of Dialysate Magnesium on Plasma and Erythrocyte Magnesium and Potassium Concentrations during Maintenance Haemodialysis

Stewart¹,

Fleming²

1973

Nephron

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“…Previous studies provided evidence for a massively increased intracellular Ca 2+ concentration in red blood cells (RBCs) of patients with end-stage renal disease (ESRD) (Paschen et al, 1971; Gafter et al, 1989), whereas the dialysis procedure itself led in average to an even slightly decreased RBC's Ca 2+ content (Paschen et al, 1971; Długaszek et al, 2008). Based on a single cell approach we could qualitatively confirm these results (Figure 1A, 2 leftmost columns), although the extend of the Ca 2+ increase was smaller compared to the cited investigations, which is presumably caused by differences in the methodology.…”

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confidence: 99%

Calcium homeostasis in red blood cells of dialysis patients in dependence of erythropoietin treatment

Wang

Bentum²,

Sester

et al. 2014

Front. Physiol.

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“…Conn., USA). The Mg content of erythrocytes was calculated by the difference of Mg content in the whole blood (MgB) and in serum (MgS) following the equation [(MgB -MgS) x 100/(Hkt x 0.97)] + MgS according to Paschen et al [22]. Fractional excretion of filtered Mg (FEMg) was calculated with the following equation: FEMg = (urinary Mg/MgS) x (serum creatinine/ urinary creatinine) x 100.…”

Section: Biochemical Determinationsmentioning

confidence: 99%

Magnesium Metabolism: Basic Aspects and Implications of Ciclosporine Toxicity in Rats

Rob

Lebeau

Nobiling

et al. 1996

Nephron

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In rapidly growing male Sprague-Dawley rats with an initial body weight of 100 ± 10 g, we investigated how alimentary magnesium (Mg) supply, Mg metabolism and ciclosporine (Ci)-associated nephrotoxicity are interrelated. Food with 100 ppm Mg (lMg) or 1,000 ppm Mg (stMg) or 10,000 ppm Mg (rMg), Ci 20 mg/kg body weight daily or olive oil were applied for 3 months (n = 10/group). Mg concentrations in various compartments were measured by atomic absorption spectrophotometry. Creatinine clearance (Jaffé), urinary N-acetyl-β-D-glucosaminidase (NAG) activity (fiuorometrically), urinary sodium excretion (flame photometry) and osmolality were measured. Histomorphological examination was done and renal renin expression was studied by monoclonal antibodies. Ci reduced the Mg concentration of the femur under lMg(72.6 ± 9.7 vs. 112.6 ± 14.3 mmol/kg dry substance, p < 0.05) and under stMg (150.6 ± 16.6 vs. 194.1 ± 10.2 mmol/kg dry substance, p < 0.05), thus indicating Ci-related Mg deficiency. This was due to a significant increase in Mg excretion in Ci treatment compared to dietary controls. Under rMg, there was no difference between Ci-treated and control animals. Ci treatment lowered creatinine clearance in lMg (1.42 ± 0.05 vs. 3.02 ± 0.58 ml/min) and in stMg (1.04 ± 0.45 vs. 2.18 ± 0.51 ml/min), NAG/creatinine and urinary sodium excretion were negatively affected by Ci under lMg and stMg. Histomorphology showed macrocalcifications due to Mg deficiency and Ci-specifïc findings, which were markedly enhanced in lMg and stMg. Animals with plentiful Mg supply had no functional alterations due to Ci and no or weakly expressed histomorphological lesions. Renin-positive stained cells were higher in Ci-treated animals. This seems to be functionally relevant under lMg and stMg, since it was associated with sodium retention and elevated relative heart weight, indicating hypertension. Alimentary or drug-induced Mg deficiency plays a relevant role in the pathophysiology of chronic Ci nephrotoxicity. Our data suggest that Mg supplementation is helpful to reduce Ci toxicity, even if there is ‘normal’ alimentary Mg intake.

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Ver�nderungen der Calcium- und Magnesiumkonzentrationen im Plasma und in Erythrocyten w�hrend der H�modialyse

Cited by 8 publications

References 19 publications

The Effect of Dialysate Magnesium on Plasma and Erythrocyte Magnesium and Potassium Concentrations during Maintenance Haemodialysis

The Effect of Dialysate Magnesium on Plasma and Erythrocyte Magnesium and Potassium Concentrations during Maintenance Haemodialysis

Calcium homeostasis in red blood cells of dialysis patients in dependence of erythropoietin treatment

Magnesium Metabolism: Basic Aspects and Implications of Ciclosporine Toxicity in Rats

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