Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in l-NAME induced hypertensive rats

Murugesan, Saravanakumar; Raja, Boobalan

doi:10.1016/j.ejphar.2011.08.052

Cited by 93 publications

(75 citation statements)

References 35 publications

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“…GPx offers protection to the cellular and subcellular membranes from the peroxidative damage by eliminating hydrogen peroxide by utilizing reduced glutathione and H 2 O 2 as substrates to yield H 2 O and oxidized glutathione and its declined activity may be due to the reduced availability of GSH (Li et al, 2012). In consistency with the previous reports, L-NAME induced hypertensive rats showed significantly depleted levels of antioxidant enzymes in tissues (Kumar et al, 2011;Saravanakumar and Raja, 2011). Administration of D-carvone, improved the activities of enzymatic antioxidants in L-NAME induced hypertensive rats.…”

supporting

confidence: 80%

D-Carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats

Rajeshwari

Raja

2015

ILNS

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The present study was aimed to assess the antihyperlipidemic, antihypertensive and antioxidant effect of D-carvone, a monoterpene against N ω -nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension. Hypertension was prompted in adult male albino rats of the Wistar strain by oral administration of the L-NAME (40 mg/kg body weight) in drinking water for 4 weeks. Rats were treated with D-carvone (5, 10 and 20 mg/kg body weight) for four weeks. L-NAME treated rats exhibited significant increase in water intake, heart rate, aortic lipids level such as triglycerides (TG), total cholesterol (TC), free fatty acids (FFA) and significant decrease in the level of phospholipids (PL), plasma nitric oxide (NO). The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were decreased in erythrocytes of L-NAME induced hypertensive rats. Treatment with D-carvone restored all the above parameters to near normal level. These results suggest that D-carvone acts as an antihyperlipidemic, antihypertensive and antioxidant agent against L-NAME induced hypertensive rats.

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supporting

confidence: 80%

D-Carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats

Rajeshwari

Raja

2015

ILNS

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“…Previous work from our laboratory (Evangelou et al, 1998) showed that vanillylmandelic acid inhibits platelet aggregation ex vivo through platelet lipoxygenase inhibition. This property has been attributed to the vanillyl group (4-hydroxy 3-methoxy phenolic ring), based on similar actions of compounds including this structure (Kumar et al, 2011;Nakmareong et al, 2011;Saravanakumar and Raja, 2011;Srivastava et al, 1995). The results derived from the present study extend the effects of the 3-methoxy phenolic ring on the cardiovascular system; thetrimetazidine, containing a tri-methylated ring appears less potent in comparison with vanillylmandelic acid or homovanillic acid.…”

Section: Main Findings and Comparison With Previous Studiessupporting

confidence: 50%

Cardiovascular effects of vanillylmandelic acid in rats

Kolentinis

Verginadis

Simos

et al. 2013

European Journal of Pharmacology

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“…Dentro de los componentes se encontró ácido verátrico (ácido benzoico, 3,4-dimetoxi), el cual ha sido investigado en estudios anteriores en sus propiedades antioxidantes mediante la inhibición de la producción de óxido nítrico (NO) (24,25) ; así mismo, se ha probado en animales de experimentación la posibilidad de su papel regulador de los niveles de presión arterial (26) . Estos hallazgos permiten abrir la posibilidad de que el extracto de Tabebuia obscura (Bureau & Schumann) Sandwith tenga propiedades antioxidantes que apoyen a la mejoría en pacientes con diabetes mellitus tipo 2.…”

Section: Discussionunclassified

Efecto hipoglicemiante de los extractos de tabebuia obscura (tahuari oscuro) sobre ratas con diabetes mellitus experimental

Aranda-Ventura¹,

Villacrés²,

Mego³

2016

Rev. per. med. integr.

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Objetivo: Determinar el efecto del extracto acuoso liofilizado de Tabebuia obscura (Bureau & Schumann) Sandwith (TO) (tahuari oscuro) en los valores de glicemia en ratas con diabetes inducida experimentalmente. Materiales y Métodos: Se indujo diabetes experimental con aloxano a 24 ratas macho Holtzman los cuales fueron distribuidos en cuatro grupos de seis ratas cada uno. El grupo I recibió 3 mL de agua destilada (control), Grupo II: Glibenclamida 10 mg/kg (control positivo), Grupo III: Tabebuia obscura 100 mg/kg, Grupo IV: Tabebuia obscura 200 mg/kg. Se determinó la glicemia antes y después de la inducción con aloxano. Luego se evaluo a la 1h, 3h, 6h, 12h y 24h después de administrar las intervenciones. Resultados: Se encontraron diferencias significativas (p<0.05) en los promedios y se encontró correlación lineal en los valores de glicemia de los grupos II, III y IV. El grupo III y el grupo II tuvieron desempeños similares (p=0.456) en lograr disminuir la glicemia; con un coeficiente de correlación intraclase de 0.70. Conclusión: El extracto acuoso liofilizado de Tabebuia obscura en dosis de 100 mg/kg tiene un efecto hipoglicemiante similar a la Glibenclamida a 10 mg/kg en ratas Holtzman macho con diabetes experimental inducida por aloxano.

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Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in l-NAME induced hypertensive rats

Cited by 93 publications

References 35 publications

D-Carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats

D-Carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats

Cardiovascular effects of vanillylmandelic acid in rats

Efecto hipoglicemiante de los extractos de tabebuia obscura (tahuari oscuro) sobre ratas con diabetes mellitus experimental

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