Verbal memory in non-demented patients withidiopathic Parkinsons disease

Ivory, S J; Knight, Robert G.; Longmore, Barry E.; Th, Caradoc-Davies

doi:10.1016/s0028-3932(98)00131-6

Cited by 72 publications

(57 citation statements)

References 41 publications

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“…Both phonological and semantic fluency decline over the disease course and this finding has been interpreted as an index of the progressive deterioration of executive functions in non-demented PD patients (Azuma et al, 2003). Free recall tasks are a measure of verbal learning that requires active organization of the to-be-remembered material (Taylor et al, 1986;Mohr et al, 1990), and have been widely used in Parkinson's disease (Ivory et al, 1999). Although data from literature were not always consistent, non-demented PD patients may show memory deficits attributable to frontal lobe dysfunction (Ivory et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Free recall tasks are a measure of verbal learning that requires active organization of the to-be-remembered material (Taylor et al, 1986;Mohr et al, 1990), and have been widely used in Parkinson's disease (Ivory et al, 1999). Although data from literature were not always consistent, non-demented PD patients may show memory deficits attributable to frontal lobe dysfunction (Ivory et al, 1999). Therefore, reduced fluency, verbal learning and learning efficiency in our patients with hallucinations (in presence of normal delayed recall) may be ascribed to a relative dysfunction of controlling and monitoring (executive) functions subtended by pre-frontal cortex.…”

Section: Discussionmentioning

confidence: 99%

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Frontal dysfunction contributes to the genesis of hallucinations in non-demented Parkinsonian patients

Grossi¹,

Trojano²,

Pellecchia

et al. 2005

Int. J. Geriat. Psychiatry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Frontal dysfunction contributes to the genesis of hallucinations in non-demented Parkinsonian patients

Grossi¹,

Trojano²,

Pellecchia

et al. 2005

Int. J. Geriat. Psychiatry

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“…There have been a few empirical studies evaluating metamemory deficits in PD. In a study conducted by Ivory et al (1999), no differences were found in the accuracy of metamemory judgments between a non-demented PD group and a control group of age matched adults with non-neurological illnesses such as arthritis or osteoporosis. The task employed was a general knowledge test sampled from the task created by Nelson and Narens (1980).…”

Section: Parkinson's Diseasementioning

confidence: 91%

Metamemory Experiments in Neurological Populations: A Review

2005

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Metamemory refers to knowledge about one's memory capabilities and strategies that can aid memory, as well as the processes involved in memory self-monitoring. Although metamemory has been studied in cognitive psychology for several decades, there have been fewer studies investigating the neuropsychology of metamemory. In recent years, a growing number of studies of neurological patient groups have been conducted in order to investigate the neural correlates of metamemory. In this review, we examine the neuropsychological evidence that the frontal lobes are critically involved in monitoring and control processes, which are the central components of metamemory. The following conclusions are drawn from this literature: (1) There is a strong correlation between indices of frontal lobe function or structural integrity and metamemory accuracy (2) The combination of frontal lobe dysfunction and poor memory severely impairs metamemorial processes (3) Metamemory tasks vary in subject performance levels, and quite likely, in the underlying processes these different tasks measure, and (4) Metamemory, as measured by experimental tasks, may dissociate from basic memory retrieval processes and from global judgments of memory.

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“…According to Hassler, the striatum is of fundamental importance in attentional processes 30 . Ivory et al suggest that memory defi cits in IPD may be partly explained by executive function defi cits related to the frontal dysfunction found in this disease 31 .…”

mentioning

confidence: 99%

Cognitive function assessment in idiopathic Parkinson's disease

Piovezan

Teive

Piovesan

et al. 2007

Arq. Neuro-Psiquiatr.

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-Idiopathic Parkinson's disease (PD) is characterized by reduced nigrostriatal and cortical dopaminergic influence, with changes in movement and, subsequently, behavioral and cognitive disturbances. We studied cognitive impairment in Parkinson's disease by assessing a group of 30 idiopathic Parkinson's disease patients with an average age of 64.23 years (PG group) and compared our findings with those for a control group of 30 patients (CG group). All the patients were submitted to the following assessments: motor function, using the UPDRS; staging, using the Hoehn-Yahr scales (PG group only); depression, using the Montgomery-Asberg scale; attention impairment; verbal fluency (FAR and animals); cognitive function, using the Mini Mental State Examination; visuospatial and executive functions; and clock drawing. In addition to altered motor function in PD patients, we found statistically significant differences between PD patients and controls in terms of cognitive function, verbal, executive and visuospatial functions, and attention deficits. Depression was more prevalent in the PG group.KEY WORS: depression, idiopathic Parkinson's disease, cognitive function. Avaliação da função cognitiva em doença de Parkinson idiopáticaRESUMO -A doença de Parkinson idiopática (DP) caracteriza-se pela redução da influência dopaminérgica nigroestriatal e cortical, com alterações em movimentos e posteriormente, comportamentais e cognitivas. Estudamos o comprometimento cognitivo de pacientes portadores de DP, avaliando 30 pacientes com doença de Parkinson idiopática (GP) com média de idade de 64,23 anos e os comparamos com um grupo controle (GC) de 30 pacientes. Todos os pacientes foram submetidos as seguintes avaliações: motora pela escala de UPDRS; estadiamento pela escala de Hoehn-Yahr (somente GP); depressão pela escala de Montgomery-Asberg; comprometimento da atenção; fluência verbal (FAR e animais); função cognitiva pelo Mini Exame do Estado Mental; funções visuoespaciais e executivas e desenho do relógio. Concluímos que na DP os pacientes apresentam além das alterações motoras diferenças estatisticamente significativas a nível cognitivo, na função verbal, funções executivas, visuoespaciais e distúrbios de atenção. Depressão foi mais prevalente no GP. PR -Brasil. E-mail: werneck@hc.ufpr.br Although the original description by James Parkinson 1 did not consider cognitive disturbances to be an integral part of the symptomatology of Parkinson's disease (PD), but Charcot and Vulpian 2,3 describe such disturbances for the fi rst time, and their fi ndings were confi rmed in recent studies 4,5 . Postmortem neuropathological studies and the use of in vivo PET scans show that nigrostriatal dopaminergic neuronal degeneration is the main physiopathological mechanism in Parkinson's disease 5,6 . The nigrostriatal dopaminergic system is part of one of the fi ve frontostriatal circuits 7 . Disruption of dopaminergic infl uence in these circuits has consequences for other circuits and thus explains a number of cognitive symptom...

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Verbal memory in non-demented patients withidiopathic Parkinsons disease

Cited by 72 publications

References 41 publications

Frontal dysfunction contributes to the genesis of hallucinations in non-demented Parkinsonian patients

Frontal dysfunction contributes to the genesis of hallucinations in non-demented Parkinsonian patients

Metamemory Experiments in Neurological Populations: A Review

Cognitive function assessment in idiopathic Parkinson's disease

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