Verbascoside is not genotoxic in the ST and HB crosses of the Drosophila wing spot test, and its constituent, caffeic acid, decreases the spontaneous mutation rate in the ST cross

Santos-Cruz, Luis Felipe; Ávila-Acevedo, José Guillermo; Ortega-Capitaine, Diego; Ojeda-Duplancher, Jesús Clemente; Perdigón-Moya, Juana Laura; Hernández-Portilla, Luis Barbo; López-Dionicio, Héctor; Durán‐Díaz, Ángel; Dueñas-García, Irma Elena; Castañeda-Partida, Laura; García-Bores, Ana María; Heres-Pulido, María Eugenia

doi:10.1016/j.fct.2011.12.006

Cited by 22 publications

(11 citation statements)

References 63 publications

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“…Verbascoside has shown neuroprotective potential in vitro in glioma cells C6, due to its antioxidant capacity (Esposito et al, 2010). Also, it has been determined that verbascoside does not show genotoxic activity over D. melanogaster (Santos‐Cruz et al, 2012). Furthermore, verbascoside has no teratogenic effect in mice (Etemad et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Verbascoside‐enriched fraction from Buddleja cordata Kunth ameliorates the effects of diabetic embryopathy in an animal model

Chirino-Galindo

López-Quintero

Ramírez-Domínguez

et al. 2021

Birth Defects Research

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Background The deleterious effects of diabetes mellitus (DM) over development are apparently due to an increase in oxidative stress. Some antioxidants could prevent developmental alterations produced by diabetic state. Extracts of plants of the genus Buddleja are used traditionally for Mexican indigens to ameliorate some diseases. The purpose of this work was to evaluate the effect of the extract of Buddleja cordata over diabetic embryopathy. Methods Two experimental approaches were used: an in vivo study and an in vitro model. In the first, rats were treated with streptozotocin, streptozotocin plus methanolic extract of B. cordata, or none. Females were sacrificed at gestational day (GD) 19, and biochemical clinical parameters were measured; also, the fetuses were obtained and morphologically analyzed. In the in vitro model, a verbascoside‐enriched fraction (VEF) of the extract was used in whole embryo culture in order to search for the mechanisms for embryoprotection effect over hyperglycemia‐induced malformations. Results In the in vivo experiments, B. cordata extract reduces the frequency and severity of fetal malformations produced by chemically induced diabetes, and additionally partially ameliorates the diabetic condition; in the in vitro model, both severity and frequency of embryo dysmorphogenesis were reduced by the VEF; also, this fraction reduces lipoperoxidation without affecting the activity of the antioxidant enzymes. Conclusion The results suggest that verbascoside of methanolic extract and enriched fraction can directly affect the redox state, and thus, prevents the embryotoxicity mediated by oxidative stress, in embryos of diabetic pregnancy.

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Section: Introductionmentioning

confidence: 99%

Verbascoside‐enriched fraction from Buddleja cordata Kunth ameliorates the effects of diabetic embryopathy in an animal model

Chirino-Galindo

López-Quintero

Ramírez-Domínguez

et al. 2021

Birth Defects Research

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“…However, the results may be due to instability and breakdown of verbascoside to caffeic acid and 3,4-dihydroxyphenyl ethanol in test media (Santoro et al, 2008) (caffeic acid is classified by IARC as 2B: possibly carcinogenic to humans, based on animal studies (IARC, 1993)). Verbascoside was not genotoxic in vivo in two strains of Drosophila melanogaster but the results may be due to low absorption from the gut of the compound (Santos-Cruz et al, 2012).…”

Section: Accepted Manuscript 21mentioning

confidence: 90%

Are wild and cultivated flowers served in restaurants or sold by local producers in Denmark safe for the consumer?

Pedersen

Olesen

Eriksen

et al. 2018

Food and Chemical Toxicology

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New Nordic Food has within the last decade received much media coverage with chefs of top restaurants using wild plants for foods. As part of a control campaign, the Danish Veterinary and Food Administration visited 150 restaurants and local food producers from May-October 2016 and investigated their use of plants picked from the wild, cultivated in private gardens or market gardens. Among the species used were the flowers from 23 plants. Here we present a safety evaluation of these flowers based on published phytochemical investigations and toxicological data in humans, farm animals, pets, or experimental animals. Of the 23 flowers reviewed, nine contained compounds with toxic or potentially toxic effects if eaten, two contained unidentified toxic compound(s), and four were flowers from plants with potentially toxic compounds present in other plant parts or related species. Many of the flowers may be considered novel, since a use to a significant degree in Europe prior to 15 May 1997 before Regulation (EC) 258/97 on novel food and novel food ingredients came into force could not be established. In conclusion, this review illuminates a striking lack of chemical and toxicological data of many of the proposed wild or cultivated flowers for food use.

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“…Recently, in vivo subsequent tests on Drosophila melanogaster and rabbit reported that verbascoside do not give rise to any mutagenic activity at any of the tested concentrations [48][49][50]. Besides poor in vivo bioavailability of verbascoside was reported and could be also related to this behavior [51].…”

Section: Plos Onementioning

confidence: 99%

Antimutagenic, antigenotoxic and antiproliferative activities of Fraxinus angustifolia Vahl. leaves and stem bark extracts and their phytochemical composition

et al. 2020

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In recent years, chronic degenerative diseases such as certain types of cancers, are becoming an evident issue. DNA damage has been for long recognized as a causal factor for cancer development because mutations or chromosomal aberrations affect oncogenes and tumor suppressor genes leading cells to malignant transformation and to the subsequent cancerous growth. Medicinal plants are often used for the prevention or treatment of various diseases with great scientific interest. Among the medicinal plants distributed in the Mediterranean region, Fraxinus angustifolia Vahl. has been used in traditional medicine for its remarkable curative properties. However, in spite of this popularity, little works have been performed on the activity so that further studies should be performed to investigate in depth the antimutagenic, antigenotoxic and antiproliferative activities of the plant. Thus, the present study was aimed to the evaluation of the potential antimutagenic, antigenotoxic and antiproliferative properties of leaves and stem bark extracts of this well-known tree. Antimutagenic activity was evaluated by Salmonella mutagenicity assay in Salmonella typhimurium TA98 and TA100 strains. The antigenotoxic potential was assessed by umu test in the strain of S. typhimurium TA1535/pSK1002. Antiproliferative activity was studied on human hepatoblastoma (HepG-2) and on breast adenocarcinoma (MCF-7) cell lines by MTT assay. Furthermore, the antiproliferative activity observed on cancer cells was compared with that on the human normal-like fibroblasts (TelCOFS02MA) and the selectivity index was calculated to understand if extracts were able to exert selective toxicity towards cancer cells. Moreover, phenolic compounds are plant substances with a large spectrum of biochemical activities with antioxidant, antimutagenic and anticarcinogenic effects. Based on the strong evidence of biological activities of phenolic compounds, the study was focused on the determination of total phenolics and flavonoids contents, and the phytochemical composition of the extracts assessed by LC/MS. The ethanol extracts of both leaves and stem barks showed

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Verbascoside is not genotoxic in the ST and HB crosses of the Drosophila wing spot test, and its constituent, caffeic acid, decreases the spontaneous mutation rate in the ST cross

Cited by 22 publications

References 63 publications

Verbascoside‐enriched fraction from Buddleja cordata Kunth ameliorates the effects of diabetic embryopathy in an animal model

Verbascoside‐enriched fraction from Buddleja cordata Kunth ameliorates the effects of diabetic embryopathy in an animal model

Are wild and cultivated flowers served in restaurants or sold by local producers in Denmark safe for the consumer?

Antimutagenic, antigenotoxic and antiproliferative activities of Fraxinus angustifolia Vahl. leaves and stem bark extracts and their phytochemical composition

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