Vergleich der polarographischen und kolorimetrischen Methoden zur Bestimmung von Dacarbazin

Abstract

Dacarbazin (1) laBt sich polarographisch in Konzentrationen zwischen bis lo-' mol/l qualitativ und quantitativ bestimmen. Polarographisch aktiv ist die N=N-Gruppe, die unter Aufnahme van 4 Elektronen und 4 Protonen gespalten wird. Polarolpephic and Colorimetric Determination of DacarbazineThe polarographic method is used for the identification and determination of Dacarbazine (1). The results indicate that 1 can be identified and determined as the pure compound or as a constituent of galenic preparations at concentrations between w 3 and mol/l. Polarographically active is the N=N-group, which is reduced by the addition of four electrons and four protons.Dacarbazin (1) ist ein neuartiges Krebschemotherapeutikum, das in den USA entwickelt worden i~t ' ,~,~) .

Adsorptive stripping voltammetric analysis of 2,4,6-tri(2'pyridyl)-1,3,5-triazine at a mercury electrode

“…Therefore, sensitive analytical methods are needed for the determination of trace amounts of these substances. Several analytical methods for the determination of triazine derivatives have been reported including UV-visible spectrophotometry [5,6] and polarography [7][8][9][10] but the use of these techniques is limited to a concentration level between 10\-10\ mol/l. Differential pulse stripping voltammetry has been widely applied for trace determinations of various categories of organic compounds including derivatives of pyridine, pyrimidine and purine compounds [11][12][13][14][15].…”

Polarographic Behavior and Determination of 1,1-Dimethyl-3-phenyltriazene

“…Considering the fact that triazene group is polarographically active 5 , direct current polarography has been used to study 1,1-dimethyl-3-phenyltriazene 6 and its derivatives 4 . More sensitive techniques, such as differential pulse polarography [7][8][9] and adsorptive stripping voltammetry [9][10][11] have been used for the determination of variously substituted derivatives of 1,1-dimethyl-3-phenyltriazene.…”