Vergleichende funktionelle und lichtmikroskopische Untersuchungen zur Wirkung extremer Blutverd�nnung mit Rheomacrodex, H�maccel oder Tutofusin auf die Niere

Hölscher, B.

doi:10.1007/bf01439164

Cited by 3 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The deviation of the various para meters of kidney function (clearances and U/P0Sm) from the control values is less marked than with infusion of clinical or low molecular weight dextran [85]. The exchange of half the normal blood volume with gelatin preparations [93,211], even if aggravated by the addi tional stress of extracorporeal perfusion [211], does not cause renal damage. Nor does the infusion of gelatins in amounts equalling the total normal blood volume as an emergency treatment of large blood losses in man [212,213].…”

Section: Products Division Travenol Laboratories Internationmentioning

confidence: 92%

See 1 more Smart Citation

Treatment of Shock with Dextrans and Gelatins

1969

Vox Sanguinis

View full text Add to dashboard Cite

Section: Products Division Travenol Laboratories Internationmentioning

confidence: 92%

“…The tubular epithelium and the capillary coils of the glomeruli are compressed [93,118,128,129,211,221]. Alternatively, pro nounced degrees of 'osmotic nephrosis' may be present and cause tubular obstruction by the resulting cellular swelling [59,149].…”

Section: Products Division Travenol Laboratories Internationmentioning

confidence: 99%

Treatment of Shock with Dextrans and Gelatins

1969

Vox Sanguinis

View full text Add to dashboard Cite

Literatur

Reil¹,

Rehrmann²

1978

Messung Des Blutdurchflusses in Der Art. Carotis Interna Und Bestimmung Der Parameter Des Herz-Kreislaufsystems Sowie Des Cereb

View full text Add to dashboard Cite

Zur langfristigen Wirkung eines einmaligen gleichvolumigen hochdosierten Blutersatzes durch verschiedene kolloidhaltige Infusionsl�sungen auf die Niere der Ratte

Hölscher

Obladen

1971

Langenbecks Arch Chiv

Self Cite

View full text Add to dashboard Cite

In male rats of the Wistar strain the blood volume amounting to 50 % of the initial value has been replaced by equal volumes of the commercial blood substitutes as dextran 40 in 0,9 % NaCl, Haemaccel, Gelifundol and Biseko respectively. The rats had been sacrificed at different time intervals following the replacement of blood and the kidneys histologically examined. The dilatation of the proximal convoluted tubules and the pronounced vacuolisation of the tubular cells had disappeared 4 days after treatment with dextran or gelatine solutions. The vacuoles, presumably due to an enzymic degradation of the colloidal macromolecules, are reversible and should, therefore, not be classified as osmotic nephrosis. However, after replacement of the blood by Biseko which contains human protein no histological changes of the kidneys have been observed at any time of the experimental period. The concentration of the reabsorbed relativelylarge size protein molecules is apparently too small as to bring about a noticeable appearance of vacuoles. The findings suggest that the kidney would seem to be least affected using protein solutions as blood substitutes. The question whether or not in cases of preexisting renal damage excessive doses of dextran or gelatine solutions might have additional deleterious effects on the kidney cannot be answered as yet.

show abstract

Vergleichende funktionelle und lichtmikroskopische Untersuchungen zur Wirkung extremer Blutverd�nnung mit Rheomacrodex, H�maccel oder Tutofusin auf die Niere

Cited by 3 publications

References 17 publications

Treatment of Shock with Dextrans and Gelatins

Treatment of Shock with Dextrans and Gelatins

Literatur

Zur langfristigen Wirkung eines einmaligen gleichvolumigen hochdosierten Blutersatzes durch verschiedene kolloidhaltige Infusionsl�sungen auf die Niere der Ratte

Contact Info

Product

Resources

About