Vergleichende Untersuchungen �ber die Wirkung von Dopamin und Orciprenalin am gesunden Menschen: Muskeldurchblutung, Nierendurchblutung, Nierenfunktion

Ramdohr, B; Blamino, Giancarlo; Schröder, Rolf

doi:10.1007/bf01486939

Cited by 41 publications

(11 citation statements)

References 18 publications

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“…This observation agrees with earlier reports demonstrating dopamine infusion to increase renal blood flow and GFR (McDonald et al 1964;ter Wee et al 1986; for review see Lee 1993), even though the latter was not affirmed by all studies (Ramdohr et al 1972;Schnermann et al 1990). …”

Section: Discussionsupporting

confidence: 79%

Renal effects of exogenous dopamine: modulation by renal nerves and dopamine receptor antagonists

Luippold

Oßwald

Mühlbauer

1998

Naunyn-Schmiedeberg's Arch Pharmacol

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The modulation of the renal response to exogenous dopamine by renal denervation (DNX) and dopamine receptor antagonists was investigated in thiopental-anesthetized Sprague-Dawley rats. Experiments were performed after reaching stable systemic hemodynamics and urinary flow rate. These conditions were obtained with an infusion rate of approximately 1.2% of body weight per hour. In the vehicle group (VHC) i.v. infusion of dopamine (1, 3 and 9 microg kg(-1) min(-1) significantly increased glomerular filtration rate (GFR), assessed by renal clearance of [3H]inulin, by 14+/-1.5, 16+/-1.6 and 31+/-2.6%, respectively. Infusion of 1 and 3 microg kg(-1) min(-1) dopamine did not change systemic hemodynamics while the highest dose elevated heart rate, potentially contributing to the GFR increase. The specific D1 receptor antagonist SCH 23390 (10 microg kg(-l) min(-1) i.v.) did not affect the GFR response to dopamine infusion. In contrast, domperidone (DOM; 8 microg kg(-1) min(-1) i.v.), a specific, peripherally acting D2 antagonist, attenuated the glomerular hyperfiltration induced by the three doses of dopamine to 11+/-1.7, 13+/-2.2 and 16+/-2.6%, respectively. DNX diminished the GFR response to dopamine infusion to almost the same extent (11+/-2.8, 10+/-2.2 and 17+/-2.6%, respectively) as did DOM. When DNX animals were treated with DOM, the GFR responses to dopamine were further attenuated to non-significant increases. These additive effects of DOM and DNX suggest that two different mechanisms are involved. Both DNX and SCH 23390 decreased sodium excretion at baseline whereas DOM enhanced it. Under the present experimental condition, neither D1 nor D2 receptor blockade affected the natriuretic and diuretic response to dopamine. Whereas D1 receptors do not appear to be involved, both D2 receptors and renal nerves play a role in the renal hemodynamic response to dopamine, indicating involvement of both pre- and postsynaptical dopamine receptors.

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Section: Discussionsupporting

confidence: 79%

Renal effects of exogenous dopamine: modulation by renal nerves and dopamine receptor antagonists

Luippold

Oßwald

Mühlbauer

1998

Naunyn-Schmiedeberg's Arch Pharmacol

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“…McDonald et al [4] used a minimum dose of 2.6 pg/kg/min in early studies, result ing in an increase of PAH clearance of 91% while Ramdohr et al [5] later observed a 48% increase of PAH clearance at 175 pg/kg/min. Hollenberg et al [14] did not find an increase in renal blood flow, assessed by xenon washout, at 0.3 and 1.0 pg/kg/min dopamine; however, 2 and 4 normals only were tested for these doses, respec tively.…”

Section: Discussionmentioning

confidence: 99%

“…Relatively little is known on the effects of various doses of dopamine on renal function in patients with renal disease [4,5]. In earlier studies of the so-called renal reserve filtration capacity, we found that the in crease of effective renal plasma flow (ERPF) and glomer ular filtration rate (GFR) during infusion of a fixed low dose of dopamin (1.5-2 pg/kg/min) was much less pro nounced in patients with renal disease than in normals, even if the baseline GFR was in the normal range [6].…”

Section: Introductionmentioning

confidence: 99%

Impaired Renal Hemodynamic but Conserved Natriuretic Response to Dopamine in Patients with Renal Disease

Smit¹,

Meijer²,

Wesseling³

et al. 1989

Nephron

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Renal hemodynamics and sodium excretion were determined before and during infusion of dopamine in doses ranging from 0.25 to 8 μg/kg/min in healthy volunteers (n = 15) and in patients with renal disease and moderately impaired renal function (n = 21, baseline glomerular filtration rate 34–85 ml/min). While in normal volunteers dopamine resulted in marked renal vasodilation (maximal fall in filtration fraction 24%), in patients with moderately impaired renal function, the renal vasodilatory response to dopamine was impaired (maximal fall in FF 13%) and was found to depend on baseline glomerular filtration rate. Infusion of dopamine in doses of 2 μg/kg/min and higher resulted in an increase in urinary sodium excretion, which was comparable for healthy volunteers and patients with renal disease. We conclude that dopamine results in a predominantly efferent glomerular vasodilation and, therefore, may be salutary in lowering intraglomerular hypertension. However, in patients with renal disease the renal hemodynamic response to dopamine infusion is impaired compared to healthy volunteers, while the natriuretic response is maintained.

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“…The dopamine-induced increase in renal blood flow can be accompanied by a rise in GFR and urinary output [7], At higher doses the agent also stimulates betaadrenergic cardiac receptors which increase the cardiac output. At doses in excess of 20 pg/kg/min, however, alpha receptors are stimulated, causing systemic vasocon striction and a reversal of the vasodilatation of the renal vessels achieved at low levels [8].…”

Section: Discussionmentioning

confidence: 99%

Effect of Intravenous Infusion of Low-Dose Dopamine on Renal Function in Normal Individuals and in Patients with Renal Disease

et al. 1986

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A low dose of dopamine was infused in 28 normal volunteers and in 137 patients with varying degrees of renal insufficiency during a routine measurement of the glomerular filtration rate (GFR) and the effective renal plasma flow (ERPF). Dopamine infusion led to an increase in ERPF and GFR and to a fall in the filtration fraction. The effect of dopamine on renal function was most pronounced if the baseline GFR was normal. However, healthy individuals showed greater increases in both ERPF and GFR than renal patients with a comparable baseline GFR. In renal patients no effect was observed if the baseline GFR was below 50 ml/min/1.73 m². Firstly, it is concluded that already early in renal disease there exists a diminished reserve filtration capacity. Secondly, if the GFR is less than 50 ml/min/1.73 m², the renal reserve filtration capacity seems to be exhausted.

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Vergleichende Untersuchungen �ber die Wirkung von Dopamin und Orciprenalin am gesunden Menschen: Muskeldurchblutung, Nierendurchblutung, Nierenfunktion

Cited by 41 publications

References 18 publications

Renal effects of exogenous dopamine: modulation by renal nerves and dopamine receptor antagonists

Renal effects of exogenous dopamine: modulation by renal nerves and dopamine receptor antagonists

Impaired Renal Hemodynamic but Conserved Natriuretic Response to Dopamine in Patients with Renal Disease

Effect of Intravenous Infusion of Low-Dose Dopamine on Renal Function in Normal Individuals and in Patients with Renal Disease

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