Verification of Measurement of the Feline Serum Amyloid A (SAA) Concentration by Human SAA Turbidimetric Immunoassay and Its Clinical Application

Tamamoto, Takashi; Ohno, Koichi; Ohmi, Aki; Goto‐Koshino, Yuko; Tsujimoto, Hajime

doi:10.1292/jvms.70.1247

Cited by 51 publications

(78 citation statements)

References 32 publications

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“…c, 14 The reference range of feline SAA was selected as ≤0.82 mg/l on the basis of a previous study. 14 Cats were divided into 2 groups according to SAA concentration.…”

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confidence: 99%

Serum amyloid A as a prognostic marker in cats with various diseases

et al. 2013

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Serum amyloid A (SAA) is reported not only as a marker for the presence of inflammation but also as a prognostic indicator in human beings. In cats, however, there is no report on the association between SAA concentration and prognosis. The objective of the current study was to evaluate SAA concentration as a prognostic marker in diseased cats. A total of 175 cats with neoplastic diseases, inflammatory diseases, and other diseases were retrospectively recruited, and the medical records of these cats, including follow-up data on mortality, were reviewed. Cats were divided into 2 groups according to SAA concentration, and differences in survival between each group were assessed. Median survival time of cats in the elevated SAA (>0.82 mg/l) group was significantly shorter than that in the nonelevated SAA (≤0.82 mg/l) group ( P < 0.001). Furthermore, by multivariate analysis, SAA concentration was shown as a significant and independent prognostic marker in cats with various diseases ( P = 0.015). Serum amyloid A concentration in diseased cats is a useful predictive indicator of prognosis regardless of diagnosis.

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“…c, 14 The reference range of feline SAA was selected as ≤0.82 mg/l on the basis of a previous study. 14 Cats were divided into 2 groups according to SAA concentration.…”

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confidence: 99%

Serum amyloid A as a prognostic marker in cats with various diseases

et al. 2013

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“…Measurement of SAA and AGP concentrations are considered useful in detecting the presence of inflammation (17,26,27). In addition, AGP in cat serum or effusion samples is a recognised biomarker of FIP (6,21,25).…”

Section: Methodsmentioning

confidence: 99%

Serum concentrations of some acute phase proteins in cats with anaemia

Tuna¹,

Dinler²,

̃ici³

et al. 2018

Medycyna Weterynaryjna

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SummarySerum concentrations of acute phase proteins can provide valuable diagnostic information in the detection and monitoring of disease. The available information on the acute phase response in cats with anaemia is limited. The aim of this study was to retrospectively evaluate serum concentrations of haptoglobin, serum amyloid A, α1 acid glycoprotein and their clinical importance in cats with anaemia. Thirty-four anaemic cats and ten healthy cats were enrolled this study. After individual diagnoses had been established, the cats were divided into three groups (healthy group, haemolytic group and non-haemolytic group). Serum acute phase protein concentrations were analysed using specific commercially available test kits in an ELISA reader device. Serum amyloid A and serum α1 acid glycoprotein concentrations were significantly higher in the anaemic groups compared with the healthy group. Haptoglobin concentrations were significantly higher in cats from the non-haemolytic anaemia group than they were in healthy animals and those from the haemolytic anaemia group. Although serum haptoglobin concentrations were lower than in the healthy group, there was no significant difference between the haemolytic anaemia group and the healthy group. The results of this study suggest that serum amyloid A and α1 acid glycoprotein could be useful in the diagnosis and determination of inflammation in cats with anaemia. Serum haptoglobin depletion may be used for diagnosis of haemolysis in cats with haemolytic anaemia. In addition, this study has contributed to the limited data available on acute phase protein concentrations in cats with anaemia.

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“…The measurement of SAA concentration (29.4 -88.3 mg/L) in FIP was clinically valuable to detect the infl ammatory process in affected cats [54] and a 10-fold increase has been found, suggesting its potential as a biomarker of this disease [15]. Moreover, a study suggested that the median survival time of cats with elevated SAA levels (>0.82 mg/L) was signifi cantly shorter in various diseases, including FIP [8].…”

Section: Catsmentioning

confidence: 99%

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

Schmidt

Eckersall

2015

Acta Veterinaria

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During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.

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Verification of Measurement of the Feline Serum Amyloid A (SAA) Concentration by Human SAA Turbidimetric Immunoassay and Its Clinical Application

Cited by 51 publications

References 32 publications

Serum amyloid A as a prognostic marker in cats with various diseases

Serum amyloid A as a prognostic marker in cats with various diseases

Serum concentrations of some acute phase proteins in cats with anaemia

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

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