Verification of the Antidiabetic Effects of Cinnamon (<i>Cinnamomum zeylanicum</i>) Using Insulin-Uncontrolled Type 1 Diabetic Rats and Cultured Adipocytes

Shen, Yan; Fukushima, Misato; Ito, Yoshimasa; Muraki, Etsuko; Hosono, Takashi; Seki, Taiichiro; Ariga, Toshio

doi:10.1271/bbb.100453

Cited by 107 publications

(80 citation statements)

References 27 publications

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“…Several studies also have demonstrated that the hypoglycemic or antidiabetic effect of some natural herb extracts can be attributed to their insulin-trophic effect that enables the reduction of blood glucose levels, liver glycogen content, and serum lipids through the control of serum insulin [32,33]. Similarly, our results also show that AEHE administration increased insulin production.…”

Section: Discussionsupporting

confidence: 81%

Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats

Liang

Guo

Xie

et al. 2013

BMC Complement Altern Med

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BackgroundHericium erinaceus, as a commonly used medicine or food, has attracted much attention due to its health effects when used as a home remedy for some diseases. The aim of this work was to investigate the hypoglycemic and hypolipidemic effects of aqueous extract of Hericium erinaceus (AEHE) in streptozotocin (STZ)-induced diabetic rats.MethodsDiabetes was induced in Wistar rats by the administration of STZ (55 mg/kg BW.) intraperitoneally. AEHE (100 and 200 mg/kg BW.) was administered for a period of 28 days. The effects of AEHE on glucose, insulin, and lipid files in blood, and oxidative stress parameters in the liver were evaluated. The body weights of rats were recorded at day 0, 14 and 28th days.ResultsThe administration of AEHE for 28 days in STZ diabetic rats resulted in a significant decrease in serum glucose level and a significant rise in serum insulin level. AEHE treatment attenuated lipid disorders. In addition, AEHE administration increased the activities of CAT, SOD, and GSH-Px, and GSH level, and reduced MDA level in the liver tissue significantly.ConclusionOur results suggest that AEHE possesses hypoglycemic, hypolipidemic, and antioxidant properties in STZ-induced diabetes rats.

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Section: Discussionsupporting

confidence: 81%

Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats

Liang

Guo

Xie

et al. 2013

BMC Complement Altern Med

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show abstract

“…[10] Our results demonstrate that C. zeylanicum improves the body's ability to handle a glucose load as demonstrated by the rapid metabolism shown in the cinnamon group of healthy animals following a standard oral glucose load. This probably occurs as a result of the ability of cinnamon to potentiate insulin-regulated glucose utilization via enhancing insulin signaling.…”

Section: Discussionmentioning

confidence: 72%

Effects ofCinnamomum zeylanicum(Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model

Ranasinghe¹,

Perera²,

Gunatilake³

et al. 2012

Phcog Res

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Objectives:To evaluate short- and long-term effects of Cinnamomum zeylanicum on food consumption, body weight, glycemic control, and lipids in healthy and diabetes-induced rats.Materials and Methods:The study was conducted in two phases (Phase I and Phase II), using Sprague-Dawley rats in four groups. Phase I evaluated acute effects on fasting blood glucose (FBG) (Groups 1 and 2) and on post-oral glucose (Groups 3 and 4) blood glucose. Groups 1 and 3 received distilled-water and Groups 2 and 4 received cinnamon-extracts. Phase II evaluated effects on food consumption, body weight, blood glucose, and lipids over 1 month. Group A (n = 8, distilled-water) and Group B (n = 8, cinnamon-extracts) were healthy rats, while Group C (n = 5, distilled-water) and Group D (n = 5, cinnamon-extracts) were diabetes-induced rats. Serum lipid profile and HbA1c were measured on D-0 and D-30. FBG, 2-h post-prandial blood glucose, body weight, and food consumption were measured on every fifth day.Results:Phase I: There was no significant difference in serial blood glucose values in cinnamon-treated group from time 0 (P > 0.05). Following oral glucose, the cinnamon group demonstrated a faster decline in blood glucose compared to controls (P < 0.05). Phase II: Between D0 and D30, the difference in food consumption was shown only in diabetes-induced rats (P < 0.001). Similarly, the significant difference following cinnamon-extracts in FBG and 2-h post-prandial blood glucose from D0 to D30 was shown only in diabetes-induced rats. In cinnamon-extracts administered groups, total and LDL cholesterol levels were lower on D30 in both healthy and diabetes-induced animals (P < 0.001).Conclusions:C. zeylanicum lowered blood glucose, reduced food intake, and improved lipid parameters in diabetes-induced rats.

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“…Information regarding whether spices can protect against diabetic complications has heretofore been scant. Recently, cumin, ginger, turmeric and cinnamon have been reported to help treat cataract and nephropathy in diabetic rats [22][23][24][25]. Turmeric and its constituent, curcumin, can delay the development of a cataract but does not have any effect on blood glucose [25].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Several Spices on Inflammation Caused by Advanced Glycation Endproducts

Ho¹,

Chang²

2012

AJPS

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Advanced glycation endproducts (AGEs) is implicated in the pathogenesis of diabetic complications. Inhibiting the formation of AGEs and interfering with AGEs-mediated inflammation are two practicable strategies for developing a dietary adjuvant against diabetic complications. This study evaluated the protective capacities against diabetic complications of several spices based on their inhibition of the formation of AGEs in an in vitro BSA/glucose system and on the AGEs-induced production of proinflammatory cytokine in RAW 264.7 macrophages. Among the tested spices, cinnamon exhibited most strongly inhibited both the formation of AGEs and the AGEs-induced production of nitric oxide, interleukin-6 and tumor necrosis factor-α. Additionally, correlative results revealed that the capacity of spices to inhibit the formation of AGEs is attributable to phenolic compounds and, in contrast, the capacity to inhibit AGEs-induced inflammation is attributable to condensed tannin. This investigation demonstrates the potential of cinnamon to serve as a dietary adjuvant against diabetic complications.

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Verification of the Antidiabetic Effects of Cinnamon (Cinnamomum zeylanicum) Using Insulin-Uncontrolled Type 1 Diabetic Rats and Cultured Adipocytes

Cited by 107 publications

References 27 publications

Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats

Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats

Effects ofCinnamomum zeylanicum(Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model

Inhibitory Effects of Several Spices on Inflammation Caused by Advanced Glycation Endproducts

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